arXiv:2601.08333v1 Announce Type: new Abstract: LLM-based agent architectures systematically conflate information transport mechanisms with epistemic justification mechanisms. We formalize this class of architectural failures as semantic laundering: a pattern where propositions with absent or weak warrant are accepted by the system as admissible by crossing architecturally trusted interfaces. We show that semantic laundering constitutes an architectural realization of the Gettier problem: propositions acquire high epistemic status without a connection between their justification and what makes them true. Unlike classical Gettier cases, this effect is not accidental; it is architecturally determined and systematically reproducible. The central result is the Theorem of Inevitable Self-Licensing: under standard architectural assumptions, circular epistemic justification cannot be eliminated. We introduce the Warrant Erosion Principle as the fundamental explanation for this effect and show that scaling, model improvement, and LLM-as-judge schemes are structurally incapable of eliminating a problem that exists at the type level.

arXiv:2601.08559v1 Announce Type: new Abstract: Sustainable water resource management in transboundary river basins is challenged by fragmented data, limited real-time access, and the complexity of integrating diverse information sources. This paper presents WaterCopilot-an AI-driven virtual assistant developed through collaboration between the International Water Management Institute (IWMI) and Microsoft Research for the Limpopo River Basin (LRB) to bridge these gaps through a unified, interactive platform. Built on Retrieval-Augmented Generation (RAG) and tool-calling architectures, WaterCopilot integrates static policy documents and real-time hydrological data via two custom plugins: the iwmi-doc-plugin, which enables semantic search over indexed documents using Azure AI Search, and the iwmi-api-plugin, which queries live databases to deliver dynamic insights such as environmental-flow alerts, rainfall trends, reservoir levels, water accounting, and irrigation data. The system features guided multilingual interactions (English, Portuguese, French), transparent source referencing, automated calculations, and visualization capabilities. Evaluated using the RAGAS framework, WaterCopilot achieves an overall score of 0.8043, with high answer relevancy (0.8571) and context precision (0.8009). Key innovations include automated threshold-based alerts, integration with the LRB Digital Twin, and a scalable deployment pipeline hosted on AWS. While limitations in processing non-English technical documents and API latency remain, WaterCopilot establishes a replicable AI-augmented framework for enhancing water governance in data-scarce, transboundary contexts. The study demonstrates the potential of this AI assistant to support informed, timely decision-making and strengthen water security in complex river basins.

arXiv:2601.08183v1 Announce Type: cross Abstract: Multimodal Large Language Models (MLLMs) show promise in gastroenterology, yet their performance against comprehensive clinical workflows and human benchmarks remains unverified. To systematically evaluate state-of-the-art MLLMs across a panoramic gastrointestinal endoscopy workflow and determine their clinical utility compared with human endoscopists. We constructed GI-Bench, a benchmark encompassing 20 fine-grained lesion categories. Twelve MLLMs were evaluated across a five-stage clinical workflow: anatomical localization, lesion identification, diagnosis, findings description, and management. Model performance was benchmarked against three junior endoscopists and three residency trainees using Macro-F1, mean Intersection-over-Union (mIoU), and multi-dimensional Likert scale. Gemini-3-Pro achieved state-of-the-art performance. In diagnostic reasoning, top-tier models (Macro-F1 0.641) outperformed trainees (0.492) and rivaled junior endoscopists (0.727; p>0.05). However, a critical "spatial grounding bottleneck" persisted; human lesion localization (mIoU >0.506) significantly outperformed the best model (0.345; p

arXiv:2601.08634v1 Announce Type: cross Abstract: While recent research has systematically documented political orientation in large language models (LLMs), existing evaluations rely primarily on direct probing or demographic persona engineering to surface ideological biases. In social psychology, however, political ideology is also understood as a downstream consequence of fundamental moral intuitions. In this work, we investigate the causal relationship between moral values and political positioning by treating moral orientation as a controllable condition. Rather than simply assigning a demographic persona, we condition models to endorse or reject specific moral values and evaluate the resulting shifts on their political orientations, using the Political Compass Test. By treating moral values as lenses, we observe how moral conditioning actively steers model trajectories across economic and social dimensions. Our findings show that such conditioning induces pronounced, value-specific shifts in models' political coordinates. We further notice that these effects are systematically modulated by role framing and model scale, and are robust across alternative assessment instruments instantiating the same moral value. This highlights that effective alignment requires anchoring political assessments within the context of broader social values including morality, paving the way for more socially grounded alignment techniques.

arXiv:2601.08732v1 Announce Type: cross Abstract: Accurate delineation of acute ischemic stroke lesions in MRI is a key component of stroke diagnosis and management. In recent years, deep learning models have been successfully applied to the automatic segmentation of such lesions. While most proposed architectures are based on the U-Net framework, they primarily differ in their choice of loss functions and in the use of deep supervision, residual connections, and attention mechanisms. Moreover, many implementations are not publicly available, and the optimal configuration for acute ischemic stroke (AIS) lesion segmentation remains unclear. In this work, we introduce ISLA (Ischemic Stroke Lesion Analyzer), a new deep learning model for AIS lesion segmentation from diffusion MRI, trained on three multicenter databases totaling more than 1500 AIS participants. Through systematic optimization of the loss function, convolutional architecture, deep supervision, and attention mechanisms, we developed a robust segmentation framework. We further investigated unsupervised domain adaptation to improve generalization to an external clinical dataset. ISLA outperformed two state-of-the-art approaches for AIS lesion segmentation on an external test set. Codes and trained models will be made publicly available to facilitate reuse and reproducibility.

arXiv:2504.08999v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) are increasingly augmented with external tools through standardized interfaces like the Model Context Protocol (MCP). However, current MCP implementations face critical limitations: they typically require local process execution through STDIO transports, making them impractical for resource-constrained environments like mobile devices, web browsers, and edge computing. We present MCP Bridge, a lightweight RESTful proxy that connects to multiple MCP servers and exposes their capabilities through a unified API. Unlike existing solutions, MCP Bridge is fully LLM-agnostic, supporting any backend regardless of vendor. The system implements a risk-based execution model with three security levels-standard execution, confirmation workflow, and Docker isolation - while maintaining backward compatibility with standard MCP clients. However, reliable execution within this framework requires models that can strictly adhere to protocol schemas. To this end, we also fine-tuned the Qwen3 4B and 8B model family on the Agent-Ark/Toucan-1.5M dataset using four Reinforcement Learning techniques: Group Relative Policy Optimization (GRPO), Dr. GRPO, Beta Normalization Policy Optimization (BNPO), and Decoupled Alignment Policy Optimization (DAPO). Evaluated on the MCPToolBench++ benchmark, our optimized model achieves an F1 score of 73.0% that outperforms GPT-OSS-120B (62.17%) and remains competitive with the 70B+ parameter baselines. Evaluation demonstrates that MCP Bridge successfully addresses the constraints of direct MCP connections while providing enhanced security controls and cross-platform compatibility, enabling sophisticated LLM-powered applications in previously inaccessible environments.

arXiv:2505.07917v2 Announce Type: replace-cross Abstract: Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for biomedical QA, evaluating retrieval strategies and response time trade-offs. We first assess state-of-the-art retrieval methods, including BM25, BioBERT, MedCPT, and a hybrid approach, alongside common data stores such as Elasticsearch, MongoDB, and FAISS, on a ~10% subset of PubMed (2.4M documents) to measure indexing efficiency, retrieval latency, and retriever performance in the end-to-end RAG system. Based on these insights, we deploy the final RAG system on the full 24M PubMed corpus, comparing different retrievers' impact on overall performance. Evaluations of the retrieval depth show that retrieving 50 documents with BM25 before reranking with MedCPT optimally balances accuracy (0.90), recall (0.90), and response time (1.91s). BM25 retrieval time remains stable (82ms), while MedCPT incurs the main computational cost. These results highlight previously not well-known trade-offs in retrieval depth, efficiency, and scalability for biomedical QA. With open-source code, the system is fully reproducible and extensible.

arXiv:2505.13565v2 Announce Type: replace-cross Abstract: Artificial Intelligence (AI) poses both significant risks and valuable opportunities for democratic governance. This paper introduces a dual taxonomy to evaluate AI's complex relationship with democracy: the AI Risks to Democracy (AIRD) taxonomy, which identifies how AI can undermine core democratic principles such as autonomy, fairness, and trust; and the AI's Positive Contributions to Democracy (AIPD) taxonomy, which highlights AI's potential to enhance transparency, participation, efficiency, and evidence-based policymaking. Grounded in the European Union's approach to ethical AI governance, and particularly the seven Trustworthy AI requirements proposed by the European Commission's High-Level Expert Group on AI, each identified risk is aligned with mitigation strategies based on EU regulatory and normative frameworks. Our analysis underscores the transversal importance of transparency and societal well-being across all risk categories and offers a structured lens for aligning AI systems with democratic values. By integrating democratic theory with practical governance tools, this paper offers a normative and actionable framework to guide research, regulation, and institutional design to support trustworthy, democratic AI. It provides scholars with a conceptual foundation to evaluate the democratic implications of AI, equips policymakers with structured criteria for ethical oversight, and helps technologists align system design with democratic principles. In doing so, it bridges the gap between ethical aspirations and operational realities, laying the groundwork for more inclusive, accountable, and resilient democratic systems in the algorithmic age.

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You’re back. We’re sort of back. It’s Day 2 of JPM and we’re definitely not exhausted or delirious yet.

This is Elaine Chen, Adam Feuerstein, Matt Herper, and Allison DeAngelis again. We’ve got a lot more news today, so let’s get to it.

The next test for Kite Pharma — and Gilead

It’s anito-cel, the CAR-T therapy for multiple myeloma that Gilead is developing in partnership with Arcellx. Gilead submitted the therapy to the FDA sometime before the end of December, Cindy Perettie, executive vice president of Kite Pharma, the cell therapy division of Gilead, told STAT at a Gilead media breakfast.

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OpenAI and Anthropic have each launched healthcare-focused products over the last week.

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OpenEvidence promises ‘medical super-intelligence’

It will be hard for OpenEvidence to top its 2025. The company announced nearly $500 million in funding last year and seemingly overnight became a go-to tool in the medical profession. A slide during the company’s Monday JPM presentation claims that queries to the company’s clinical evidence chatbot grew from 2.6 million in 2024 to 17.9 million in December 2025, with well over 100 million queries for the year.

The company also revealed it will be launching “medical super-intelligence.” What does that mean? Katie Palmer explains in a new story.

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