npj Digital Medicine, Published online: 17 January 2026; doi:10.1038/s41746-026-02344-8
Wearable device derived electrocardiographic age and its association with atrial fibrillation
Nat Cancer. 2026 Jan 16. doi: 10.1038/s43018-025-01107-w. Online ahead of print.
ABSTRACT
The concept of cellular neighborhoods, defined as recurring structures within the tissue with characteristic cell compositions and interactions, has transformed our understanding of the complexity and dynamics of tumor ecosystems. Recent advances in spatial omics and computational modeling have enabled high-resolution mapping of these neighborhoods, providing unprecedented insights into their roles in shaping tumor heterogeneity, evolution and therapeutic responses. Despite these advances, a unified framework for interpreting cellular neighborhoods remains lacking. This Perspective synthesizes emerging concepts and insights, focusing on the definition and classification of cellular neighborhoods in cancer, computational methods for identifying and comparing them, and their clinical relevance.
PMID:41545713 | DOI:10.1038/s43018-025-01107-w
Nature Cancer, Published online: 16 January 2026; doi:10.1038/s43018-025-01110-1
Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cells and the tumor microenvironment.
Nature Medicine, Published online: 16 January 2026; doi:10.1038/s41591-025-04073-z
Analyses of liver biopsies from a child with spinal muscular atrophy treated with adeno-associated virus gene therapy who developed hepatitis reveal contaminating manufacturing plasmids and disrupted vector genomes, possibly resulting from recombination events.
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