Normal view

Received — 27 May 2026 ⏭

Nature - Issue - nature.com science feeds
Mitochondrial <span>l</span>-2-hydroxyglutarate is a physiological signalling metabolite Ram P. Chakrabarty · Jonathan G. Van Vranken · Yuki Aoi · Taylor A. Poor · Gregory S. McElroy · Karthik Vasan · Shimaa H. A. Soliman · Marta Iwanaszko · Rogan A. Grant · Benjamin C. Howard · Colleen R. Reczek · Anjali D. Chandel · Michael Kahl · Zhaofa Xu · Kathryn A. Helmin · Qiushi Jin · Dongmei Wang · Peng Gao · Jenna L. E. Blum · Zachary L. Sebo · Feng Yue · Yongchao C. Ma · Shawn M. Davidson · Steven P. Gygi · Samuel E. Weinberg · Benjamin D. Singer · SeungHye Han · Ali Shilatifard · Navdeep S. Chandel
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10564-xl-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and function.
20 May 2026 at 08:00

Mitochondrial <span>l</span>-2-hydroxyglutarate is a physiological signalling metabolite

Nature - Issue - nature.com science feeds

By: Ram P. Chakrabarty · Jonathan G. Van Vranken · Yuki Aoi · Taylor A. Poor · Gregory S. McElroy · Karthik Vasan · Shimaa H. A. Soliman · Marta Iwanaszko · Rogan A. Grant · Benjamin C. Howard · Colleen R. Reczek · Anjali D. Chandel · Michael Kahl · Zhaofa Xu · Kathryn A. Helmin · Qiushi Jin · Dongmei Wang · Peng Gao · Jenna L. E. Blum · Zachary L. Sebo · Feng Yue · Yongchao C. Ma · Shawn M. Davidson · Steven P. Gygi · Samuel E. Weinberg · Benjamin D. Singer · SeungHye Han · Ali Shilatifard · Navdeep S. Chandel

20 May 2026 at 08:00

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10564-x

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and function.