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Nitrogen dioxide exposure promotes CD8(+)T cell infiltration and contributes to increased susceptibility to ulcerative colitis: An integrative multi-omics, artificial intelligence, and mouse model study

J Hazard Mater. 2026 Sep 15;516:143449. doi: 10.1016/j.jhazmat.2026.143449. Epub 2026 Aug 30.

ABSTRACT

The global incidence of ulcerative colitis (UC) has significantly increased in rapidly industrializing nations, with numerous studies highlighting environmental exposures, particularly nitrogen dioxide (NO2), as potential contributors to disease susceptibility. However, the clinical implications and molecular mechanisms linking NO2 exposure to UC susceptibility remain poorly understood. This study investigated the associations between NO2 and UC by integrating multi-omics data. We identified a CD8+ T cell subpopulation with a distinct phenotype characterized by perforin production, which potentially exacerbated colonic inflammation related to NO2 exposure. To validate this hypothesis, we established mouse models exposed to NO2, confirming increased CD8+ T cell infiltration and elevated perforin secretion through immunofluorescent (IF) staining. Employing artificial intelligence techniques, we identified Cell Division Cycle 25B (CDC25B) as a gene of interest correlated with putative NO2-related UC signatures. Finally, through molecular docking (MD) and molecular dynamics simulations (MDS), we identified ozanimod as one of several computationally nominated compounds associated with the CDC25B‑related network; however, none of these computational predictions were experimentally validated in the present study. Collectively, these findings suggest a correlative link between perforin or CD8+ T cell-associated colonic inflammation and NO2-associated UC susceptibility, and nominate CDC25B as a candidate gene for further investigation.

PMID:42679583 | DOI:10.1016/j.jhazmat.2026.143449

AVBench: Human-Aligned and Automated Evaluation Benchmark for Audio-Video Generative Models

arXiv:2605.24652v1 Announce Type: new Abstract: Rapid advances in audio-video (AV) generation have enabled high-fidelity synthesis with synchronized sound, particularly for human-related scenarios involving speech and interactions. Yet evaluation for AV generation remains at an early stage, with only a few coarse-grained benchmarks for human-related scenarios and relying on limited preset evaluations with generic multimodal LLMs, leading to inaccurate assessments of model capabilities. To address these issues, we introduce AVBench, a fully automated benchmark tailored for human-centric AV generation. AVBench is built on two key designs for comprehensive and accurate evaluation: (i) Human-centric and fine-grained metrics. AVBench integrates ten evaluation dimensions designed for human-centered real-world scenarios, covering visual quality, audio quality, and multi-level consistency across modalities. These practical metrics capture human-related details that existing benchmarks often overlook. (ii) Specialized evaluators via preference learning. To address the lack of specialized training data, we construct large-scale supervision by transforming real-world videos into diverse training pairs with controlled perturbations. After fine-tuning on this high-quality dataset, the evaluators learn to reliably detect subtle cross-modal inconsistencies. Crucially, instead of producing discrete textual judgment, AVBench derives continuous evaluation scores from the model's prediction confidence on binary decisions. This probabilistic scoring mechanism enables a more reliable assessment than traditional VQA-style evaluation and aligns closely with human judgment. Taken together, AVBench offers automated evaluation for AV generation, demonstrates strong potential for data filtering, and serves as a differentiable reward signal for Reinforcement Learning from Human Feedback (RLHF).

Ego-Grounding for Personalized Question-Answering in Egocentric Videos

arXiv:2604.01966v1 Announce Type: cross Abstract: We present the first systematic analysis of multimodal large language models (MLLMs) in personalized question-answering requiring ego-grounding - the ability to understand the camera-wearer in egocentric videos. To this end, we introduce MyEgo, the first egocentric VideoQA dataset designed to evaluate MLLMs' ability to understand, remember, and reason about the camera wearer. MyEgo comprises 541 long videos and 5K personalized questions asking about "my things", "my activities", and "my past". Benchmarking reveals that competitive MLLMs across variants, including open-source vs. proprietary, thinking vs. non-thinking, small vs. large scales all struggle on MyEgo. Top closed- and open-source models (e.g., GPT-5 and Qwen3-VL) achieve only~46% and 36% accuracy, trailing human performance by near 40% and 50% respectively. Surprisingly, neither explicit reasoning nor model scaling yield consistent improvements. Models improve when relevant evidence is explicitly provided, but gains drop over time, indicating limitations in tracking and remembering "me" and "my past". These findings collectively highlight the crucial role of ego-grounding and long-range memory in enabling personalized QA in egocentric videos. We hope MyEgo and our analyses catalyze further progress in these areas for egocentric personalized assistance. Data and code are available at https://github.com/Ryougetsu3606/MyEgo

Learning Memory-Enhanced Improvement Heuristics for Flexible Job Shop Scheduling

arXiv:2603.02846v1 Announce Type: cross Abstract: The rise of smart manufacturing under Industry 4.0 introduces mass customization and dynamic production, demanding more advanced and flexible scheduling techniques. The flexible job-shop scheduling problem (FJSP) has attracted significant attention due to its complex constraints and strong alignment with real-world production scenarios. Current deep reinforcement learning (DRL)-based approaches to FJSP predominantly employ constructive methods. While effective, they often fall short of reaching (near-)optimal solutions. In contrast, improvement-based methods iteratively explore the neighborhood of initial solutions and are more effective in approaching optimality. However, the flexible machine allocation in FJSP poses significant challenges to the application of this framework, including accurate state representation, effective policy learning, and efficient search strategies. To address these challenges, this paper proposes a Memory-enhanced Improvement Search framework with heterogeneous graph representation--MIStar. It employs a novel heterogeneous disjunctive graph that explicitly models the operation sequences on machines to accurately represent scheduling solutions. Moreover, a memoryenhanced heterogeneous graph neural network (MHGNN) is designed for feature extraction, leveraging historical trajectories to enhance the decision-making capability of the policy network. Finally, a parallel greedy search strategy is adopted to explore the solution space, enabling superior solutions with fewer iterations. Extensive experiments on synthetic data and public benchmarks demonstrate that MIStar significantly outperforms both traditional handcrafted improvement heuristics and state-of-the-art DRL-based constructive methods.
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