arXiv:2609.12454v1 Announce Type: cross Abstract: Vision-Language Models such as CLIP enable effective few-shot medical anomaly detection (AD) via strong image-text semantic alignment. However, their globally contrastive pretraining lacks explicit spatial supervision, limiting precise lesion localization. In contrast, Vision Foundation Models (VFMs) such as DINO learn spatially coherent patch representations via self-distillation and local-to-global consistency, better capturing fine-grained anatomical structures. Leveraging this complementarity, we propose Spatial-FAD, a spatial-aware few-shot medical AD framework that improves lesion localization by combining VFM spatial priors with CLIP semantics. Specifically, we introduce a VFM-enhanced adapter that injects a structural affinity prior derived from DINO into CLIP features. This structure-guided refinement encourages visual embeddings to better adhere to lesion boundaries while maintaining semantic alignment. To address the loss of spatial detail from patchification and the limited input resolution of CLIP, we adopt a sliding-window aggregation strategy. This generates high-resolution, spatially dense embeddings to further enhance localization granularity. Moreover, we introduce a prototype-enhanced support memory scheme to efficiently exploit the few-shot support set. This module stores compact prototypes for normal and abnormal patterns, reducing memory costs while boosting performance by fusing patch-to-prototype and image-text similarities. Extensive experiments on three benchmark datasets, including Liver CT, Retinal OCT, and Brain MRI, demonstrate that Spatial-FAD significantly outperforms state-of-the-art methods, especially in lesion segmentation. Notably, in the 4-shot scenario, our method achieves an average improvement of over 11.4% in Dice score and 1.8% in AUC. Code is available at: https://github.com/JuzhengMiao/Spatial-FAD.

arXiv:2607.27231v3 Announce Type: replace Abstract: Modern AI systems depend on specialized accelerator kernels, whose development is complicated by increasingly diverse operators and hardware. LLMs and agentic systems promise to automate this work, but existing evaluations do not show whether their performance transfers across operator sources and hardware platforms, or what such transfer costs. We present KernelGenBench, the first unified multi-source and multi-chip infrastructure for evaluating LLM- and agent-generated Triton kernels. With a common Triton target spanning six hardware platforms, it provides the broadest cross-vendor hardware coverage among existing kernel-generation benchmarks. We report two controlled analytical views: KernelGenBench-MS (Multi-Source) covers 210 operators from PyTorch ATen, production vLLM operators, and proprietary cuBLAS routines, while KernelGenBench-MC (Multi-Chip) evaluates a semantically stable 110-operator subset across six hardware platforms. Our evaluation consumed over 15 billion tokens. Agentic execution improved correctness, but no method dominated across sources and platforms: vLLM posed the strongest correctness challenge, cuBLAS set the highest performance ceiling, and AutoKernel accuracy fell from 87% on NVIDIA to 25% on Iluvatar CoreX. These improvements were costly: specialized agents averaged 4.99 million tokens per successful operator, rising to 6.25 million for CUDA Optimized Skill. The results establish operator source, hardware platform, and agentic scaffold as distinct dimensions of kernel-generation capability, and show that success in a familiar source-hardware setting is not a reliable proxy for deployment readiness.

Nature Cancer, Published online: 25 May 2026; doi:10.1038/s43018-026-01165-8

In this phase 2 trial, Perez et al. reported the safety of the vitamin D receptor agonist paricalcitol with gemcitabine and nab-paclitaxel in patients with metastatic pancreatic ductal adenocarcinoma and the pharmacodynamic effects of paricalcitol in fibroblasts and immune cells.