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AnyMo: Geometry-Aware Setup-Agnostic Modeling of Human Motion in the Wild

arXiv:2605.22715v2 Announce Type: replace-cross Abstract: As wearable and mobile devices become increasingly embedded in daily life, they offer a practical way to continuously sense human motion in the wild. But inertial signals are highly dependent on the sensing setup, including body location, mounting position, sensor orientation, device hardware, and sampling protocol. This setup dependence makes it difficult to learn motion representations that transfer across devices and datasets, and limits the broader use of wearable IMUs beyond closed-set recognition. We introduce AnyMo, a geometry-aware framework for setup-agnostic human motion modeling. AnyMo uses physics-grounded IMU simulation over dense body-surface placements to generate diverse and plausible synthetic signals, pre-trains a graph encoder from paired synthetic placement views and masked partial observations, tokenizes multi-position IMU into full-body motion tokens, and aligns these tokens with an LLM for motion-language understanding. We evaluate AnyMo on three complementary tasks: zero-shot activity recognition across 14 unseen downstream datasets, cross-modal retrieval, and wearable IMU motion captioning, where it improves average Accuracy/F1/R@2 by 11.7\%/11.6\%/22.6\% on HAR, increases zero-shot IMU-to-text and text-to-IMU retrieval MRR by 15.9\% and 28.6\%, respectively, and improves zero-shot captioning BERT-F1 by 18.8\%. These results support AnyMo as a generalist model for wearable motion understanding in the wild. Project page: https://baiyuchen.com/project/AnyMo.

Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models

A mitochondrial transplantation approach rescues mitochondrial deficiency and prevents mitochondrial DNA depletion syndrome, Leigh syndrome, and Parkinson’s disease in cellular and mouse models.

Dynamic Manifold Hopfield Networks for Context-Dependent Associative Memory

arXiv:2506.01303v3 Announce Type: replace-cross Abstract: Neural population activity in cortical and hippocampal circuits can be flexibly reorganized by context, suggesting that cognition relies on dynamic manifolds rather than static representations. However, how such dynamic organization can be realized mechanistically within a unified dynamical system remains unclear. Continuous Hopfield networks provide a classical attractor framework in which neural dynamics follow gradient descent on a fixed energy landscape, constraining retrieval within a static attractor manifold geometry. Extending this approach, we introduce Dynamic Manifold Hopfield Networks (DMHN), continuous dynamical models in which contextual modulation dynamically reshapes attractor geometry, transforming a static attractor manifold into a context-dependent family of neural manifolds. In DMHN, network interactions are learned in a data-driven manner, to intrinsically deform the geometry of its attractor manifold across cues without explicit context-specific parameterization. As a result, in associative retrieval, DMHN achieve substantially higher capacity and robustness than classical and modern Hopfield networks: when storing $2N$ patterns in a network of $N$ neurons, DMHN attain reliable retrieval with an average accuracy of 64%, compared with 1% and 13% for classical and modern variants, respectively. Together, these results establish dynamic reorganization of attractor manifold geometry as a principled mechanism for context-dependent remapping in neural associative memory.
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