Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10276-2Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and energetic framework to explain cold sensitivity.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10281-5Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occurs during parasite infections.