Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-wThis Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.