Normal view

Received — 10 September 2026 ⏭

Molecular Therapy
Integrin α7 defines a profibrotic adipose stromal population targeted for nanoparticle PAI-1 gene silencing in obesity Linda Mota · David Zhang · Yulieth Soto Ortiz · Federico Zertuche Gonzalez · Eunhee Chung · Caleb Dang · Achraf Noureddine · Eric M. Brey · Maria A. Gonzalez Porras
Obesity expands a pathogenic ITGA7high adipose stromal cell population that promotes fibrosis. We engineered ITGA7-targeted lipid-coated mesoporous silica nanoparticles to selectively deliver plasminogen activator inhibitor-1 small interfering RNA, suppress profibrotic signaling, and restore a healthier adipose microenvironment.
10 August 2026 at 08:00

Integrin α7 defines a profibrotic adipose stromal population targeted for nanoparticle PAI-1 gene silencing in obesity

By: Linda Mota · David Zhang · Yulieth Soto Ortiz · Federico Zertuche Gonzalez · Eunhee Chung · Caleb Dang · Achraf Noureddine · Eric M. Brey · Maria A. Gonzalez Porras

10 August 2026 at 08:00

Obesity expands a pathogenic ITGA7high adipose stromal cell population that promotes fibrosis. We engineered ITGA7-targeted lipid-coated mesoporous silica nanoparticles to selectively deliver plasminogen activator inhibitor-1 small interfering RNA, suppress profibrotic signaling, and restore a healthier adipose microenvironment.