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cs.AI, q-bio.NC updates on arXiv.org
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FLOAT Drone: A Fully-actuated Coaxial Aerial Robot for Close-Proximity Operations
arXiv:2503.00785v2 Announce Type: replace-cross Abstract: How to endow aerial robots with the ability to operate in close proximity remains an open problem. The core challenges lie in the propulsion system's dual-task requirement: generating manipulation forces while simultaneously counteracting gravity. These competing demands create dynamic coupling effects during physical interactions. Furthermore, rotor-induced airflow disturbances critically undermine operational reliability. Although full
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cs.AI, q-bio.NC updates on arXiv.org
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SEA-Eval: A Benchmark for Evaluating Self-Evolving Agents Beyond Episodic Assessment
arXiv:2604.08988v3 Announce Type: replace Abstract: Current LLM-based agents demonstrate strong performance in episodic task execution but remain constrained by static toolsets and episodic amnesia, failing to accumulate experience across task boundaries. This paper formalizes the Self-Evolving Agent (SEA) from the perspective of digital embodiment and continuous cross-task evolution, introduces the Evolutionary Flywheel as its minimal sufficient architecture, and presents SEA-Eval -- the first
SEA-Eval: A Benchmark for Evaluating Self-Evolving Agents Beyond Episodic Assessment
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cs.AI, q-bio.NC updates on arXiv.org
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MOSS: Self-Evolution through Source-Level Rewriting in Autonomous Agent Systems
arXiv:2605.22794v2 Announce Type: replace Abstract: Autonomous agentic systems are largely static after deployment: they do not learn from user interactions, and recurring failures persist until the next human-driven update ships a fix. Self-evolving agents have emerged in response, but all confine evolution to text-mutable artifacts -- skill files, prompt configurations, memory schemas, workflow graphs -- and leave the agent harness untouched. Since routing, hook ordering, state invariants, an
MOSS: Self-Evolution through Source-Level Rewriting in Autonomous Agent Systems
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Omics In Lung
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Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer
Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612
Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer
Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.
ABSTRACT
[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].
PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer
Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.ABSTRACT[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612
Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer
Front Immunol. 2026 Mar 16;17:1822612. doi: 10.3389/fimmu.2026.1822612. eCollection 2026.
ABSTRACT
[This corrects the article DOI: 10.3389/fimmu.2026.1782545.].
PMID:41918731 | PMC:PMC13033988 | DOI:10.3389/fimmu.2026.1822612
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables t
RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy
Nat Commun. 2026 Mar 23. doi: 10.1038/s41467-026-70798-1. Online ahead of print.
ABSTRACT
Glioblastoma (GBM) remains a lethal brain tumor due to therapy resistance. While autophagy contributes to temozolomide (TMZ) resistance, its regulation is incompletely understood. This study investigates the role of replication factor RFC4, which is associated with poor prognosis and TMZ resistance in GBM. Multi-omics analyses and molecular experiments reveal that TMZ-induced chromatin accessibility enables transcription factor YY1 to bind the RFC4 promoter and upregulate its expression. RFC4, in turn, stabilizes the kinase STK38, which is essential for autophagosome formation. The RFC4-STK38 interaction facilitates BECN1 recruitment, thereby activating autophagy. Phosphorylation of STK38 at T444 stabilizes this complex, whereas a phospho-deficient mutant impairs autophagy. In vivo, RFC4 overexpression confers TMZ resistance, reversible by autophagy inhibition. Thus, our findings identify the RFC4-STK38-BECN1 axis as a mechanism underlying TMZ resistance and a potential target for precision therapy in GBM.
PMID:41872171 | DOI:10.1038/s41467-026-70798-1
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cs.AI, q-bio.NC updates on arXiv.org
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When Silence Is Golden: Can LLMs Learn to Abstain in Temporal QA and Beyond?
arXiv:2602.04755v2 Announce Type: replace-cross Abstract: Large language models (LLMs) rarely admit uncertainty, often producing fluent but misleading answers, rather than abstaining (i.e., refusing to answer). This weakness is even evident in temporal question answering, where models frequently ignore time-sensitive evidence and conflate facts across different time-periods. In this paper, we present the first empirical study of training LLMs with an abstention ability while reasoning about tem