Nature Nanotechnology, Published online: 08 September 2026; doi:10.1038/s41565-026-02275-1Structured light–matter interaction at the single-photon level is demonstrated in a coupled quantum-dot–micropillar system, enabling cavity-enhanced single-photon emission with spin-locked orbital angular momentum and tunable spin–orbit entanglement.

A multi-omic single-cell atlas of the aging mouse brain reveals cell-type-specific transposon methylation changes, strengthening of 3D genome boundaries, and regionally heterogeneous aging signatures. These findings offer a resource to understand the molecular mechanisms of brain aging and guide future research on neurodegeneration.