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cs.AI, q-bio.NC updates on arXiv.org
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The Anatomy and Boundary of Adaptation under Temporal Tabular Shift
arXiv:2609.12136v1 Announce Type: cross Abstract: Prequential adaptation of frozen tabular foundation models under temporal drift, with each label revealed only after prediction, helps some deployments and harms others, yet current practice does not predict which. We study the sources and limits of these gains. A diagnostic anatomy attributes gains to four recurring mechanisms under a streaming protocol that removes three optimistic biases and quantifies a fourth. Within an agnostic total-varia
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cs.AI, q-bio.NC updates on arXiv.org
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Generative AI Assisted Workflows in Architectural Conceptual Design: Performance, Creative Self-Efficacy, and Cognitive Load
arXiv:2601.10696v2 Announce Type: replace Abstract: Generative AI (GenAI) is increasingly adopted in design education, yet evaluating its educational value through final outcomes provides an incomplete picture. This study compares two ecologically plausible workflows in an architectural conceptual design task: GenAI-assisted image generation and ArchDaily-based precedent search. The comparison concerns complete workflows rather than the isolated contributions. Thirty-six students completed a tw
Generative AI Assisted Workflows in Architectural Conceptual Design: Performance, Creative Self-Efficacy, and Cognitive Load
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cs.AI, q-bio.NC updates on arXiv.org
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Lumina-OmniLV: A Unified Multimodal Framework for General Low-Level Vision
arXiv:2504.04903v3 Announce Type: replace-cross Abstract: We present Lunima-OmniLV (abbreviated as OmniLV), a universal multimodal multi-task framework for low-level vision that addresses over 100 sub-tasks across four major categories: image restoration, image enhancement, weak-semantic dense prediction, and stylization. OmniLV leverages both textual and visual prompts to offer flexible and user-friendly interactions. Built on Diffusion Transformer (DiT)-based generative priors, our framework
Lumina-OmniLV: A Unified Multimodal Framework for General Low-Level Vision
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cs.AI, q-bio.NC updates on arXiv.org
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GigaBrain-WBC-0.5: A Behavior World Model for Robust Whole-Body Control with Environment Interaction
arXiv:2608.18234v3 Announce Type: replace-cross Abstract: Whole-body motion tracking policies turn a humanoid into a robust control interface: the teleoperator---or an upstream model---only supplies a coarse movement intent, while the low-level policy keeps the robot balanced and physically feasible. Existing trackers deliver this interface only on flat ground: trained in empty scenes, they never learn how contact with terrain and objects reshapes their dynamics, and they attempt to teach the p
GigaBrain-WBC-0.5: A Behavior World Model for Robust Whole-Body Control with Environment Interaction
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Journal of Medical Internet Research
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The Effectiveness of Digital Intervention on Psychological Resilience in Postoperative Breast Cancer Patients During Chemotherapy Intervals: Quasi-Experimental Study
Background: Patients with breast cancer during postoperative chemotherapy intervals commonly experience psychological distress and reduced resilience while recovering at home. Digital mindfulness interventions may provide accessible psychological support during this vulnerable period; however, evidence regarding tailored interventions for postoperative patients with breast cancer during chemotherapy intervals remains limited. Objective: This study aimed to examine the effectiveness of a digital
The Effectiveness of Digital Intervention on Psychological Resilience in Postoperative Breast Cancer Patients During Chemotherapy Intervals: Quasi-Experimental Study
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Cell Death Discovery nature.com science feeds
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Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m<sup>6</sup>A modification
Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-xFibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m6A modification
Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m<sup>6</sup>A modification
Cell Death Discovery, Published online: 11 September 2026; doi:10.1038/s41420-026-03338-x
Fibronectin 1 mediated histone lactylation promotes malignant progression of GIST regulated by m6A modification-
Molecular Therapy
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Viral gene replication enhances AAV vector quality and reduces manufacturing costs
Liu and colleagues developed a robust in cellulo plasmid DNA replication system in human cells for replicating plasmid-borne adeno-associated virus (AAV) Rep/Cap genes during recombinant AAV (rAAV) production. This new approach not only enables a 10- to 20-fold plasmid reduction to significantly lower manufacturing costs but also substantially enhances rAAV potency, titer, and purity.
Viral gene replication enhances AAV vector quality and reduces manufacturing costs
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Molecular Therapy
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The DreAM-plus integrative RNA switch enhances transient AAV expression and reduces side effects of gene editing
This study developed a multi-layer inducible RNA switch that achieves transient expression of gene-delivery vectors in hepatic and non-hepatic tissues. As an exemplary application, this RNA switch triggers pulsive expression of gene editors that reduces the off-target effects and immunotoxicity of gene editing.
The DreAM-plus integrative RNA switch enhances transient AAV expression and reduces side effects of gene editing
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cs.AI, q-bio.NC updates on arXiv.org
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Time-Frequency Geometric Cross-Attention for Chunked Vision-Language-Action Models
arXiv:2609.09925v1 Announce Type: new Abstract: Modern vision-language-action (VLA) policies predict a whole chunk of actions: one to two seconds of coordinated motion emitted in a single forward pass. Yet an action chunk is essentially a short multivariate trajectory, but inside these models it is a sequence of generic per-timestep hidden tokens decoded by a linear head. This under-serves two motion structures. First, frequency: a chunk superimposes a smooth global trend and fine corrective mo
Time-Frequency Geometric Cross-Attention for Chunked Vision-Language-Action Models
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cs.AI, q-bio.NC updates on arXiv.org
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AgentHijack: Visual Patch Attacks on Multimodal Computer-Use Agents
arXiv:2609.09212v1 Announce Type: cross Abstract: This paper presents an end-to-end evaluation framework for image-triggered command injection against computer-use agents (CUAs). The goal is to test whether a local visual patch can induce verifiable environmental consequences along the full chain of screenshot input, VLM generation, action parsing, and environment execution. We train and deploy patches on author-controlled GitHub Pages pages and a locally deployed CSDN clone, and evaluate them
AgentHijack: Visual Patch Attacks on Multimodal Computer-Use Agents
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cs.AI, q-bio.NC updates on arXiv.org
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Harbor Adapters and Harbor-Index: Infrastructure and a Curated Meta-Dataset for Large-Scale Agentic Evaluation
arXiv:2609.04298v2 Announce Type: replace Abstract: Evaluating agents on the growing number of agentic benchmarks is challenging because they often require complex environments and agent integrations. We introduce Harbor Adapters, a unified evaluation infrastructure for agentic benchmarks. Our work makes three contributions. First, we develop benchmark adapters that port more than 80 benchmarks to evaluate arbitrary agents, and validate them through rigorous code review and parity experiments.
Harbor Adapters and Harbor-Index: Infrastructure and a Curated Meta-Dataset for Large-Scale Agentic Evaluation
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cs.AI, q-bio.NC updates on arXiv.org
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LightNav-0: Eliciting VLM Spatial Intelligence for Generalist Embodied Navigation
arXiv:2608.30935v2 Announce Type: replace-cross Abstract: Embodied navigation requires agents to translate heterogeneous goals and visual observations into actions across tasks, environments, and robot embodiments. Modern vision-language models (VLMs) already encode spatial priors for visual grounding, spatial reasoning, and pointing, but these capabilities are rarely elicited directly for robot control. Existing navigation systems instead rely on task- or embodiment-specific components, fragme
LightNav-0: Eliciting VLM Spatial Intelligence for Generalist Embodied Navigation
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(Multiomics OR Omics) AND (Pancreatic)
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The redox architecture of gestational diabetes mellitus: from cellular stress engine to epigenetic and mitochondrial rewiring
Free Radic Biol Med. 2026 Sep 9;256:441-460. doi: 10.1016/j.freeradbiomed.2026.09.006. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is a common pregnancy complication with a rising global prevalence, posing serious short-term and long-term health threats to both mothers and offspring. This review repositions GDM as a systemic disorder in which oxidative stress acts as a proposed mechanistic hub, linking upstream risk factors to downstream pathophysiology. We first examine ho
The redox architecture of gestational diabetes mellitus: from cellular stress engine to epigenetic and mitochondrial rewiring
Free Radic Biol Med. 2026 Sep 9;256:441-460. doi: 10.1016/j.freeradbiomed.2026.09.006. Online ahead of print.
ABSTRACT
Gestational diabetes mellitus (GDM) is a common pregnancy complication with a rising global prevalence, posing serious short-term and long-term health threats to both mothers and offspring. This review repositions GDM as a systemic disorder in which oxidative stress acts as a proposed mechanistic hub, linking upstream risk factors to downstream pathophysiology. We first examine how "upstream" factors-including genetic susceptibility, pre-conception status, and environmental exposures-converge to promote a state of pathological redox imbalance. We then examine key mechanistic pathways through which oxidative stress is thought to contribute to systemic insulin resistance and pancreatic β-cell failure, highlighting novel pathways involving intercellular communication via tunneling nanotubes and exosomes. Furthermore, we explore the downstream cascade, where oxidative stress may program maternal accelerated biological aging and multi-organ offspring disease trajectories through nuclear epigenetic programming and mitochondrial dysfunction programming, leaving what has been termed a persistent "metabolic memory". Consequently, this review evaluates emerging strategies that target oxidative stress for early prediction and precision intervention. Early prediction models based on direct redox biomarkers and multi-omics signatures hold potential to shift diagnosis from late-gestation oral glucose tolerance test (OGTT) to first-trimester risk stratification. Current supporting evidence draws from human epidemiological associations, ex vivo placental analyses, and experimental models. However, direct causal and interventional validation in pregnant women remains limited. Integrating targeted redox risk stratification and precision interventions into a life-course clinical framework may help interrupt the intergenerational transmission of metabolic disease initiated by GDM.
PMID:42716407 | DOI:10.1016/j.freeradbiomed.2026.09.006
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(Multiomics OR Omics) AND (Pancreatic)
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Perioperative Modulation of the Gut-Liver Axis in Liver Surgery: Clinical Evidence and Future Directions
J Vis Exp. 2026 Sep 1;(235). doi: 10.3791/73747.ABSTRACTLiver resection and liver transplantation remain cornerstone treatments for many hepatobiliary diseases, yet postoperative infection, impaired liver regeneration, and post-hepatectomy liver failure (PHLF) remain serious complications. Perioperative stressors can disrupt the gut-liver axis by altering the intestinal microbiota, epithelial barrier integrity, microbial metabolites, bile acid signaling, and host immunity. This review examines h
Perioperative Modulation of the Gut-Liver Axis in Liver Surgery: Clinical Evidence and Future Directions
J Vis Exp. 2026 Sep 1;(235). doi: 10.3791/73747.
ABSTRACT
Liver resection and liver transplantation remain cornerstone treatments for many hepatobiliary diseases, yet postoperative infection, impaired liver regeneration, and post-hepatectomy liver failure (PHLF) remain serious complications. Perioperative stressors can disrupt the gut-liver axis by altering the intestinal microbiota, epithelial barrier integrity, microbial metabolites, bile acid signaling, and host immunity. This review examines how these alterations relate to clinical outcomes and evaluates evidence for microbiota-targeted interventions, including probiotics, synbiotics, nutritional optimization, antibiotic stewardship, bile acid modulation, and emerging multiomics strategies. We distinguish liver resection from living-donor and deceased-donor liver transplantation because the patient populations, graft or remnant anatomy, ischemia-reperfusion exposures, immune status, and outcome definitions differ. Clinical evidence most consistently supports selected pro-/synbiotic strategies for reducing postoperative infection in higher-risk settings, whereas microbiome-based prediction of PHLF, fecal microbiota transplantation (FMT), bile acid-directed therapy, and precision multiomics-guided pathways remain investigational. Future work should use transparent literature identification, standardized perioperative protocols, risk-defined populations, external validation, and prospective multicenter trials. A better understanding of gut-liver interactions may help preserve beneficial host-microbial signals while limiting translocation and inflammation during recovery.
PMID:42683887 | DOI:10.3791/73747
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cs.AI, q-bio.NC updates on arXiv.org
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Advancing Graph Few-Shot Learning via In-Context Learning
arXiv:2605.24410v1 Announce Type: new Abstract: Graph few-shot learning, which aims to classify nodes from novel classes with only a few labeled examples, is a widely studied problem in graph learning. However, existing methods often face two key limitations. First, the predominant graph few-shot learning paradigm relies on supervised tasks, failing to leverage the vast number of unlabeled nodes in the graph. Second, many approaches require complex task adaptation or fine-tuning during inferenc
Advancing Graph Few-Shot Learning via In-Context Learning
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cs.AI, q-bio.NC updates on arXiv.org
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Inverting the Shield: Systematically Generating Safety Tests from Policy Specifications
arXiv:2605.24883v1 Announce Type: new Abstract: The widespread integration of Large Language Models (LLMs) necessitates rigorous and systematic safety evaluation. Existing paradigms either rely on constructed benchmarks to assess safety from predefined perspectives, or employ dynamic red-teaming to probe potential vulnerabilities. While effective, these approaches face challenges, as they depend heavily on expert domain knowledge, offer limited systematic guarantees, and are vulnerable to rapid
Inverting the Shield: Systematically Generating Safety Tests from Policy Specifications
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cs.AI, q-bio.NC updates on arXiv.org
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ADMFormer: An Adaptive-Decomposition Transformer with Time-Varying Masked Spatial Attention for Traffic Forecasting
arXiv:2605.25543v1 Announce Type: new Abstract: Accurate traffic forecasting is essential for intelligent transportation systems, supporting a wide range of real-world applications. However, it remains challenging due to two key factors:~(1) Traffic series contain heterogeneous temporal patterns, where stable periodic regularities coexist with event-driven fluctuations. Existing methods often treat them within a unified representation, limiting their ability to capture fine-grained temporal dyn
ADMFormer: An Adaptive-Decomposition Transformer with Time-Varying Masked Spatial Attention for Traffic Forecasting
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cs.AI, q-bio.NC updates on arXiv.org
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PHGNet: Prototype-Guided Hypergraph Construction for Heterogeneous Spatiotemporal Forecasting
arXiv:2605.25554v1 Announce Type: new Abstract: As a core task in intelligent transportation systems, traffic forecasting plays a critical role in urban traffic management. Accurate traffic forecasting relies on modeling complex spatiotemporal dependencies, which is inherently challenging due to spatial heterogeneity in traffic systems.Despite significant progress, most existing methods are still limited to pairwise spatial dependency modeling, making it difficult to capture dynamic high-order
PHGNet: Prototype-Guided Hypergraph Construction for Heterogeneous Spatiotemporal Forecasting
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cs.AI, q-bio.NC updates on arXiv.org
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MindAlign: Bridging EEG, Vision, and Language for Zero-Shot Visual Decoding
arXiv:2605.24523v1 Announce Type: cross Abstract: Visual decoding from brain signals is a key challenge at the intersection of computer vision and neuroscience, requiring methods that bridge neural representations and computational models of vision. We introduce a tri-modal contrastive framework for EEG-based visual decoding that aligns EEG, visual, and textual representations within a unified latent space. Our approach follows a two-stage design. First, we pre-train an EEG encoder via masked r
MindAlign: Bridging EEG, Vision, and Language for Zero-Shot Visual Decoding
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cs.AI, q-bio.NC updates on arXiv.org
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What Are We Actually Decoding? Source Attribution for Non-Invasive Brain-to-Language Retrieval
arXiv:2605.24524v1 Announce Type: cross Abstract: In non-invasive neural language decoding, results can be inflated by sources that are not stimulus-evoked neural evidence: decoder priors, embedding-based metrics, and non-neural structural nuisances such as signal duration. The methodological challenge is therefore attribution: a reported gain is more informative when it can be traced to a specific source. We recast stimulus-locked MEG-to-audio retrieval as an auditing framework that separates