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Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer

Cell. 2026 Sep 29:S0092-8674(26)01081-0. doi: 10.1016/j.cell.2026.09.012. Online ahead of print.

ABSTRACT

Cachexia is a major cause of morbidity in pancreatic cancer, but the cellular circuitry linking tumor progression to systemic wasting remains incompletely understood. Integrating single-cell RNA sequencing, Xenium spatial transcriptomics, multiplex immunohistochemistry, bulk transcriptomics, and functional studies across human non-cachexia, pre-cachexia, and cachexia samples, together with mouse models, we define a cachexia-associated microenvironmental niche composed of SEMA4A+ tumor cells, AQP9+ macrophages, and LOXL2+ cancer-associated fibroblasts. Mechanistically, SEMA4A-associated signaling promotes bone morphogenetic protein-2 (BMP2)-dependent acquisition of an AQP9-associated macrophage phenotype, and macrophage-derived CXCL8 activates LOXL2+ fibroblasts. LOXL2+ fibroblasts reciprocally enhance tumor cell FOSL1/SEMA4A signaling through exosomal N-glycosylated LOXL2. Spatial analyses demonstrate progressive enrichment of this niche with cachexia severity and association with postoperative development of cachexia in previously non-cachectic patients. These findings provide a framework linking local tumor ecosystem dynamics to cachexia progression.

PMID:42810340 | DOI:10.1016/j.cell.2026.09.012

Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02593-7

Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes

Accelerating Video Generation Inference with Sequential-Parallel 3D Positional Encoding Using a Global Time Index

arXiv:2603.06664v1 Announce Type: cross Abstract: Diffusion Transformer (DiT)-based video generation models inherently suffer from bottlenecks in long video synthesis and real-time inference, which can be attributed to the use of full spatiotemporal attention. Specifically, this mechanism leads to explosive O(N^2) memory consumption and high first-frame latency. To address these issues, we implement system-level inference optimizations for a causal autoregressive video generation pipeline. We adapt the Self-Forcing causal autoregressive framework to sequence parallel inference and implement a sequence-parallel variant of the causal rotary position embedding which we refer to as Causal-RoPE SP. This adaptation enables localized computation and reduces cross-rank communication in sequence parallel execution. In addition, computation and communication pipelines are optimized through operator fusion and RoPE precomputation. Experiments conducted on an eight GPU A800 cluster show that the optimized system achieves comparable generation quality, sub-second first-frame latency, and near real-time inference speed. For generating five second 480P videos, a 1.58x speedup is achieved, thereby providing effective support for real-time interactive applications.

Agent Data Protocol: Unifying Datasets for Diverse, Effective Fine-tuning of LLM Agents

arXiv:2510.24702v2 Announce Type: replace-cross Abstract: Public research results on large-scale supervised finetuning of AI agents remain relatively rare, since the collection of agent training data presents unique challenges. In this work, we argue that the bottleneck is not a lack of underlying data sources, but that a large variety of data is fragmented across heterogeneous formats, tools, and interfaces. To this end, we introduce the agent data protocol (ADP), a light-weight representation language that serves as an "interlingua" between agent datasets in diverse formats and unified agent training pipelines downstream. The design of ADP is expressive enough to capture a large variety of tasks, including API/tool use, browsing, coding, software engineering, and general agentic workflows, while remaining simple to parse and train on without engineering at a per-dataset level. In experiments, we unified a broad collection of 13 existing agent training datasets into ADP format, and converted the standardized ADP data into training-ready formats for multiple agent frameworks. We performed SFT on these data, and demonstrated an average performance gain of ~20% over corresponding base models, and delivers state-of-the-art or near-SOTA performance on standard coding, browsing, tool use, and research benchmarks, without domain-specific tuning. All code and data are released publicly, in the hope that ADP could help lower the barrier to standardized, scalable, and reproducible agent training.
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