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PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMs

arXiv:2603.09943v2 Announce Type: replace Abstract: Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking morphological evidence with formal diagnostic and grading criteria. Although multimodal large language models (MLLMs) demonstrate strong vision language reasoning capabilities, they lack explicit mechanisms for structured knowledge integration and interpretable memory control. As a result, existing models struggle to consistently incorporate pathology-specific diagnostic standards during reasoning. Inspired by the hierarchical memory process of human pathologists, we propose PathMem, a memory-centric multimodal framework for pathology MLLMs. PathMem organizes structured pathology knowledge as a long-term memory (LTM) and introduces a Memory Transformer that models the dynamic transition from LTM to working memory (WM) through multimodal memory activation and context-aware knowledge grounding, enabling context-aware memory refinement for downstream reasoning. PathMem achieves SOTA performance across benchmarks, improving WSI-Bench report generation (12.8% WSI-Precision, 10.1% WSI-Relevance) and open-ended diagnosis by 9.7% and 8.9% over prior WSI-based models.

STING signaling modulation by COPII cargo recognition

25 March 2026 at 08:00
Lyu et al. identify the STING-ER-exit motif and the mechanism of its recognition by the COPII vesicle cargo-binding protein SEC24C. This study reveals how STING achieves controlled rather than constitutive ER exit and how COPII cargo recognition of STING can be modulated to control STING signaling.

Diff-KD: Diffusion-based Knowledge Distillation for Collaborative Perception under Corruptions

arXiv:2604.02061v1 Announce Type: new Abstract: Multi-agent collaborative perception enables autonomous systems to overcome individual sensing limits through collective intelligence. However, real-world sensor and communication corruptions severely undermine this advantage. Crucially, existing approaches treat corruptions as static perturbations or passively conform to corrupted inputs, failing to actively recover the underlying clean semantics. To address this limitation, we introduce Diff-KD, a framework that integrates diffusion-based generative refinement into teacher-student knowledge distillation for robust collaborative perception. Diff-KD features two core components: (i) Progressive Knowledge Distillation (PKD), which treats local feature restoration as a conditional diffusion process to recover global semantics from corrupted observations; and (ii) Adaptive Gated Fusion (AGF), which dynamically weights neighbors based on ego reliability during fusion. Evaluated on OPV2V and DAIR-V2X under seven corruption types, Diff-KD achieves state-of-the-art performance in both detection accuracy and calibration robustness.
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