Normal view

Received — 27 May 2026 ⏭

Nature - Issue - nature.com science feeds
Linear RAG scanning mediates editing of Igκ variable region repertoires Xiang Li · Hongli Hu · Yiwen Zhang · Tammie Zhu · Ying Guan · Kai Xu · Xin Lin · Camille Hebert · Himanshu Batra · Jenny Zhou · Zhaoqing Ba · Duane R. Wesemann · Adam Yongxin Ye · Frederick W. Alt
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.
15 April 2026 at 08:00

Linear RAG scanning mediates editing of Igκ variable region repertoires

Nature - Issue - nature.com science feeds

By: Xiang Li · Hongli Hu · Yiwen Zhang · Tammie Zhu · Ying Guan · Kai Xu · Xin Lin · Camille Hebert · Himanshu Batra · Jenny Zhou · Zhaoqing Ba · Duane R. Wesemann · Adam Yongxin Ye · Frederick W. Alt

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5

Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.