❌

Normal view

From Rubrics to Reliable Scores: Evidence-Grounded Text Evaluation with LLM Judges

arXiv:2601.08654v3 Announce Type: replace-cross Abstract: Rubric-based text evaluation increasingly relies on large language models (LLMs) as scalable judges, yet frozen black-box models can interpret the same criteria inconsistently, produce score attributions that are difficult to audit, and map judgments poorly onto human scoring scales. We define this challenge as criteria transfer: translating human rubric intent into a stable, auditable inference-time scoring protocol. We introduce Rulers, which locks a task-level rubric specification, executes it through structured, evidence-grounded judgments, and calibrates the resulting signals to human score boundaries. Across four rubric-governed benchmarks and multiple frozen backbone models, Rulers achieves stronger agreement with human scores in most evaluated settings, while better matching empirical score distributions and remaining more stable under semantically equivalent rubric perturbations. Calibration controls and component ablations show that these gains cannot be attributed to post-hoc alignment alone, but depend on the combination of fixed criteria, traceable evidence, and calibrated score interpretation. These findings suggest that reliable LLM judging requires faithfully operationalizing human evaluation standards rather than relying on prompt-level scoring alone. Our code is available at https://github.com/LabRAI/Rulers.git.

Targeting KRAS reprograms a Treg-dominant immunosuppressive microenvironment and sensitizes KRAS-mutant gastric adenocarcinoma to CTLA-4 immunotherapy

Sci China Life Sci. 2026 Sep 3. doi: 10.1007/s11427-026-3438-4. Online ahead of print.

ABSTRACT

Oncogenic KRAS mutations define a distinct molecular subset of gastric adenocarcinoma (GA), yet their impact on the tumor immune microenvironment remains incompletely understood. In this study, we established a genetically faithful and immunocompetent KRASG12D-driven mouse model of GA, together with matched organoids and cell lines, to investigate how oncogenic KRAS shapes tumor-immune interactions. KRAS-mutant tumors consistently developed an immunosuppressive microenvironment characterized by enrichment of regulatory T cells (Tregs), accompanied by reduced cytotoxic lymphocyte infiltration and intrinsic resistance to PD-1 blockade. Although pharmacologic targeting of KRAS effectively suppressed tumor growth and increased immune cell infiltration, functional immune analyses revealed persistent Treg-mediated immunosuppression that limited effective antitumor immunity. Mechanistically, TGF-Ξ² signaling was required to maintain Treg dominance and suppress effector T cell function in KRAS-driven tumors. Importantly, disruption of this suppressive axis through combined KRAS inhibition and CTLA-4 blockade attenuated TGF-Ξ² activity, impaired Treg function, and enhanced antitumor immune responses in vivo. Collectively, these findings identify oncogenic KRAS as a key regulator of TGF-Ξ²-dependent immune suppression in GA and provide mechanistic insight into immune evasion within this molecular subtype.

PMID:42714795 | DOI:10.1007/s11427-026-3438-4

❌