Normal view

Received — 27 May 2026 ⏭

Nature - Issue - nature.com science feeds
mRNA vaccines engage unconventional pathways in CD8<sup>+</sup> T cell priming Suin Jo · Lijin Li · Chandrani Thakur · Kevin A. Telfer · Hussein Sultan · Ray A. Ohara · Michelle He · Giri Nam · Jing Chen · Feiya Ou · Monia Draghi · Nicholas M. Valiante · Robert D. Schreiber · Gwendalyn J. Randolph · Naresha Saligrama · Theresa L. Murphy · William E. Gillanders · Kenneth M. Murphy
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.
15 April 2026 at 08:00

mRNA vaccines engage unconventional pathways in CD8<sup>+</sup> T cell priming

Nature - Issue - nature.com science feeds

By: Suin Jo · Lijin Li · Chandrani Thakur · Kevin A. Telfer · Hussein Sultan · Ray A. Ohara · Michelle He · Giri Nam · Jing Chen · Feiya Ou · Monia Draghi · Nicholas M. Valiante · Robert D. Schreiber · Gwendalyn J. Randolph · Naresha Saligrama · Theresa L. Murphy · William E. Gillanders · Kenneth M. Murphy

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6

mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.