Nature Biomedical Engineering, Published online: 06 October 2026; doi:10.1038/s41551-026-01780-x

A long-term flexible electrode array system stably tracks individual neurons for months, revealing intrinsic drift in visual evoked neural activity and potentiating durable cross-session and cross-animal decoding.

arXiv:2604.03299v1 Announce Type: cross Abstract: 3D human pose estimation is a key enabling technology for applications such as healthcare monitoring, human-robot collaboration, and immersive gaming, but real-world deployment remains challenged by viewpoint variations. Existing methods struggle to generalize to unseen camera viewpoints, require large amounts of training data, and suffer from high inference latency. We propose MoViD, a viewpoint-invariant 3D human pose estimation framework that disentangles viewpoint information from motion features. The key idea is to extract viewpoint information from intermediate pose features and leverage it to enhance both the robustness and efficiency of pose estimation. MoViD introduces a view estimator that models key joint relationships to predict viewpoint information, and an orthogonal projection module to disentangle motion and view features, further enhanced through physics-grounded contrastive alignment across views. For real-time edge deployment, MoViD employs a frame-by-frame inference pipeline with a view-aware strategy that adaptively activates flip refinement based on the estimated viewpoint. Evaluations on nine public datasets and newly collected multiview UAV and gait analysis datasets show that MoViD reduces pose estimation error by over 24.2\% compared to state-of-the-art methods, maintains robust performance under severe occlusions with 60\% less training data, and achieves real-time inference at 15 FPS on NVIDIA edge devices.

arXiv:2603.28532v2 Announce Type: replace-cross Abstract: Low left ventricular ejection fraction (LEF) frequently remains undetected until progression to symptomatic heart failure, underscoring the need for scalable screening strategies. Although artificial intelligence-enabled electrocardiography (AI-ECG) has shown promise, existing approaches rely solely on end-to-end black-box models with limited interpretability or on tabular systems dependent on commercial ECG measurement algorithms with suboptimal performance. We introduced ECG-based Predictor-Driven LEF (ECGPD-LEF), a structured framework that integrates foundation model-derived diagnostic probabilities with interpretable modeling for detecting LEF from ECG. Trained on the benchmark EchoNext dataset comprising 72,475 ECG-echocardiogram pairs and evaluated in predefined independent internal (n=5,442) and external (n=16,017) cohorts, our framework achieved robust discrimination for moderate LEF (internal AUROC 88.4%, F1 64.5%; external AUROC 86.8%, F1 53.6%), consistently outperforming the official end-to-end baseline provided with the benchmark across demographic and clinical subgroups. Interpretability analyses identified high-impact predictors, including normal ECG, incomplete left bundle branch block, and subendocardial injury in anterolateral leads, driving LEF risk estimation. Notably, these predictors independently enabled zero-shot-like inference without task-specific retraining (internal AUROC 75.3-81.0%; external AUROC 71.6-78.6%), indicating that ventricular dysfunction is intrinsically encoded within structured diagnostic probability representations. This framework reconciles predictive performance with mechanistic transparency, supporting scalable enhancement through additional predictors and seamless integration with existing AI-ECG systems.

Background: Stroke is a leading cause of long-term upper limb disability, severely impacting patients’ independence and quality of life. Robot-assisted therapy (RAT) has emerged as a promising, high-intensity rehabilitation alternative. However, conclusions from existing systematic reviews on its efficacy are inconsistent and often lack a holistic framework, limiting their use for guiding personalized clinical decisions. Objective: This study aims to systematically synthesize recent evidence on RAT for upper limb rehabilitation after stroke. Guided by the International Classification of Functioning, Disability and Health framework, it moves beyond singular outcomes to provide a multidimensional evaluation across body function, activity, and participation levels. The review aims to provide stratified guidance for clinical decision-making based on patient- and intervention-specific characteristics, thereby supporting evidence-based practice and informing future research. Methods: This study included systematic reviews and meta-analyses published from January 1, 2019, to December 26, 2025, comparing RAT with conventional therapy for upper limb rehabilitation after stroke. Overall, 6 databases, including PubMed, Web of Science, and Embase, were searched. Two reviewers (XZ and LZ) independently performed study selection, data extraction, and quality assessment using the AMSTAR 2 tool. The synthesis integrated outcome measures and subgroup analyses derived from the included studies. Results: This umbrella review included 21 meta-analyses encompassing 535 randomized controlled trials and 27,598 patients across acute, subacute, and chronic stroke stages. According to AMSTAR 2, 17 reviews were high quality, 3 moderate, and 1 critically low. The synthesis demonstrated that RAT was superior in improving upper limb motor function, but no statistically significant advantages were observed in activities of daily living compared to conventional therapy. Subgroup analyses revealed that treatment effects were influenced by stroke stage, upper limb motor impairment level, and robot type. Conclusions: RAT is an effective intervention for improving upper limb motor function after stroke. However, its benefits are primarily observed at the level of body function, with limited evidence for long-term maintenance. The current evidence is constrained by significant outcome heterogeneity and methodological limitations inherent to umbrella reviews. Future research should validate these findings in broader clinical practice, focus on translating functional gains into sustained improvements in daily activities and participation, and include cost-effectiveness evaluations. Trial Registration: PROSPERO CRD42024497183; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024497183

arXiv:2603.22153v2 Announce Type: replace-cross Abstract: Recent advances in cross-view geo-localization (CVGL) methods have shown strong potential for supporting unmanned aerial vehicle (UAV) navigation in GNSS-denied environments. However, existing work predominantly focuses on matching UAV views to onboard map tiles, which introduces an inherent trade-off between accuracy and storage overhead, and overlooks the importance of the UAV's heading during navigation. Moreover, the substantial discrepancies and varying overlaps in cross-view scenarios have been insufficiently considered, limiting their generalization to real-world scenarios. In this paper, we present Bearing-UAV, a purely vision-driven cross-view navigation method that jointly predicts UAV absolute location and heading from neighboring features, enabling accurate, lightweight, and robust navigation in the wild. Our method leverages global and local structural features and explicitly encodes relative spatial relationships, making it robust to cross-view variations, misalignment, and feature-sparse conditions. We also present Bearing-UAV-90k, a multi-city benchmark for evaluating cross-view localization and navigation. Extensive experiments show encouraging results that Bearing-UAV yields lower localization error than previous matching/retrieval paradigm across diverse terrains. Our code and dataset will be made publicly available.

arXiv:2602.19248v1 Announce Type: cross Abstract: The collection and detection of video anomaly data has long been a challenging problem due to its rare occurrence and spatio-temporal scarcity. Existing video anomaly detection (VAD) methods under perform in open-world scenarios. Key contributing factors include limited dataset diversity, and inadequate understanding of context-dependent anomalous semantics. To address these issues, i) we propose LAVIDA, an end-to-end zero-shot video anomaly detection framework. ii) LAVIDA employs an Anomaly Exposure Sampler that transforms segmented objects into pseudo-anomalies to enhance model adaptability to unseen anomaly categories. It further integrates a Multimodal Large Language Model (MLLM) to bolster semantic comprehension capabilities. Additionally, iii) we design a token compression approach based on reverse attention to handle the spatio-temporal scarcity of anomalous patterns and decrease computational cost. The training process is conducted solely on pseudo anomalies without any VAD data. Evaluations across four benchmark VAD datasets demonstrate that LAVIDA achieves SOTA performance in both frame-level and pixel-level anomaly detection under the zero-shot setting. Our code is available in https://github.com/VitaminCreed/LAVIDA.