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Gut dysbiosis, metabolic signals, and pulmonary immune reprogramming: decoding the gut microbiota -immune axis in stroke-associated pneumonia

Front Immunol. 2026 Aug 27;17:1812306. doi: 10.3389/fimmu.2026.1812306. eCollection 2026.

ABSTRACT

Stroke-associated pneumonia (SAP) is the most common infectious complication following acute stroke. The limited efficacy of conventional antimicrobial therapy suggests that SAP may be fundamentally a syndrome driven by dysregulated cross-system interactions. This review proposes the "gut microbiota-immune axis" (GMIA) as a comprehensive framework for the development of SAP and systematically discusses the potential mechanisms by which post-stroke microbial-derived metabolic signals-including short-chain fatty acids (SCFAs), bile acids, tryptophan metabolites, and endotoxins-drive systemic immune reprogramming, predisposing patients to SAP. Based on the GMIA, we highlight several promising intervention strategies, including dietary modulation, precision antibiotic use, probiotics, fecal microbiota transplantation (FMT), supplementation with microbial metabolites, and receptor-targeted therapies, and summarize the current clinical translation related to the GMIA. Future research directions require high-quality clinical trials that integrate multi-omics data from the microbiome with immune biomarkers and clinical parameters. Such an approach is essential for constructing validated risk stratification models and advancing the management of SAP from empirical anti-infective treatment toward a precision medicine model centered on GMIA-based immune modulation.

PMID:42724580 | PMC:PMC13560329 | DOI:10.3389/fimmu.2026.1812306

Cross-Modal Purification and Fusion for Small-Object RGB-D Transmission-Line Defect Detection

arXiv:2602.01696v5 Announce Type: replace-cross Abstract: Transmission line defect detection remains challenging for automated UAV inspection due to the dominance of small-scale defects, complex backgrounds, and illumination variations. Existing RGB-based detectors, despite recent progress, struggle to distinguish geometrically subtle defects from visually similar background structures under limited chromatic contrast. This paper proposes CMAFNet, a Cross-Modal Alignment and Fusion Network that integrates RGB appearance and depth geometry through a principled purify-then-fuse paradigm. CMAFNet consists of a Semantic Recomposition Module that performs dictionary-based feature purification via a learned codebook to suppress modality-specific noise while preserving defect-discriminative information, and a Contextual Semantic Integration Framework that captures global spatial dependencies using partial-channel attention to enhance structural semantic reasoning. Position-wise normalization within the purification stage enforces explicit reconstruction-driven cross-modal alignment, ensuring statistical compatibility between heterogeneous features prior to fusion. Extensive experiments on the TLRGBD benchmark, where 94.5% of instances are small objects, demonstrate that CMAFNet achieves 32.2% mAP@50 and 12.5% APs, outperforming the strongest baseline by 9.8 and 4.0 percentage points, respectively. A lightweight variant reaches 24.8% mAP50 at 228 FPS with only 4.9M parameters, surpassing all YOLO-based detectors while matching transformer-based methods at substantially lower computational cost.

Cross-Modal Purification and Fusion for Small-Object RGB-D Transmission-Line Defect Detection

arXiv:2602.01696v3 Announce Type: replace-cross Abstract: Transmission line defect detection remains challenging for automated UAV inspection due to the dominance of small-scale defects, complex backgrounds, and illumination variations. Existing RGB-based detectors, despite recent progress, struggle to distinguish geometrically subtle defects from visually similar background structures under limited chromatic contrast. This paper proposes CMAFNet, a Cross-Modal Alignment and Fusion Network that integrates RGB appearance and depth geometry through a principled purify-then-fuse paradigm. CMAFNet consists of a Semantic Recomposition Module that performs dictionary-based feature purification via a learned codebook to suppress modality-specific noise while preserving defect-discriminative information, and a Contextual Semantic Integration Framework that captures global spatial dependencies using partial-channel attention to enhance structural semantic reasoning. Position-wise normalization within the purification stage enforces explicit reconstruction-driven cross-modal alignment, ensuring statistical compatibility between heterogeneous features prior to fusion. Extensive experiments on the TLRGBD benchmark, where 94.5% of instances are small objects, demonstrate that CMAFNet achieves 32.2% mAP@50 and 12.5% APs, outperforming the strongest baseline by 9.8 and 4.0 percentage points, respectively. A lightweight variant reaches 24.8% mAP50 at 228 FPS with only 4.9M parameters, surpassing all YOLO-based detectors while matching transformer-based methods at substantially lower computational cost.
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