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Towards Considerate Human-Robot Coexistence: A Dual-Space Framework of Robot Design and Human Perception in Healthcare

arXiv:2604.04374v1 Announce Type: cross Abstract: The rapid advancement of robotics, spanning expanded capabilities, more intuitive interaction, and more integration into real-world workflows, is reshaping what it means for humans and robots to coexist. Beyond sharing physical space, this coexistence is increasingly characterized by organizational embeddedness, temporal evolution, social situatedness, and open-ended uncertainty. However, prior work has largely focused on static snapshots of attitudes and acceptance, offering limited insight into how perceptions form and evolve, and what active role humans play in shaping coexistence as a dynamic process. We address these gaps through in-depth follow-up interviews with nine participants from a 14-week co-design study on healthcare robots. We identify the human perception space, including four interpretive dimensions (i.e., degree of decomposition, temporal orientation, scope of reasoning, and source of evidence). We enrich the conceptual framework of human-robot coexistence by conceptualizing the mutual relationship between the human perception space and the robot design space as a co-evolving loop, in which human needs, design decisions, situated interpretations, and social mediation continuously reshape one another over time. Building on this, we propose considerate human-robot coexistence, arguing that humans act not only as design contributors but also as interpreters and mediators who actively shape how robots are understood and integrated across deployment stages.

Integrated Machine Learning and Multi-Omics Identifies a Novel Molecular Signature for Improving the Prognosis of Hepatocellular Carcinoma

J Hepatocell Carcinoma. 2026 Mar 11;13:574690. doi: 10.2147/JHC.S574690. eCollection 2026.

ABSTRACT

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits significant molecular heterogeneity and complex immune microenvironment, which to some extent limits the accuracy of prognosis assessment and the formulation of individualized treatment strategies. This study aims to identify immune-derived molecular signatures based on multi-omics data and machine learning methods for the prognosis prediction and risk stratification of HCC.

METHODS: Based on weighted gene co-expression network analysis(WGCNA) and differential gene analysis,immune-derived molecular signature (IDMS) were screened in both single-cell and bulk transcriptomes. Prognostic model was constructed by multi-machine learning approachs. Subsequently, we investigated the differences in mutations, biological functions, and immune cell infiltration within the tumor microenvironment between the high- and low-risk groups.In addition, we comprehensively analyzed the drug sensitivity of IDMS and predicted potential drugs.

RESULTS: We identified seven hub genes at the single-cell and bulk transcriptome levels. Based on multiple machine learning, we constructed a prognostic model that demonstrated excellent performance in predicting overall survival for patients with HCC. IDMS -integrated normograms provide a promising and quantitative tool for clinical risk management.Notably, a significant difference in microsatellite instability (MSI) was observed between the high- and low-risk groups. This indicates that patients in the high-risk group might have a better response to immunotherapy. Additionally, we predicted potential drugs targeting to these risk subgroups.

CONCLUSION: Our research developed an IDMS that could serve as an effective tool for patient stratification management and prognosis prediction. This signature could provide a reference for immunotherapy for patients with HCC and improve their prognosis.

PMID:41847219 | PMC:PMC12991065 | DOI:10.2147/JHC.S574690

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