Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
CoRe-Code: Collaborative Reinforcement Learning for Code Generation
arXiv:2605.24812v1 Announce Type: new Abstract: Large language models (LLMs) have achieved strong performance in code generation, but most methods rely on autoregressive decoding without global planning, often leading to locally coherent yet globally suboptimal solutions (e.g., failing test cases or inefficient complexity). While recent approaches such as Chain-of-Thought (CoT) and multi-agent systems (MAS) introduce planning, their limited role specialization and coordination hinder performanc
-
Oncogenesis - nature.com science feeds
-
SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer
Oncogenesis, Published online: 13 April 2026; doi:10.1038/s41389-026-00614-4SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer
SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer
Oncogenesis, Published online: 13 April 2026; doi:10.1038/s41389-026-00614-4
SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer-
AAAS: Table of Contents
-
High-temperature memristors enabled by interfacial engineering
Science, Ahead of Print.
High-temperature memristors enabled by interfacial engineering
-
cs.AI, q-bio.NC updates on arXiv.org
-
Chain-of-Authorization: Internalizing Authorization into Large Language Models via Reasoning Trajectories
arXiv:2603.22869v1 Announce Type: new Abstract: Large Language Models (LLMs) have become core cognitive components in modern artificial intelligence (AI) systems, combining internal knowledge with external context to perform complex tasks. However, LLMs typically treat all accessible data indiscriminately, lacking inherent awareness of knowledge ownership and access boundaries. This deficiency heightens risks of sensitive data leakage and adversarial manipulation, potentially enabling unauthori
Chain-of-Authorization: Internalizing Authorization into Large Language Models via Reasoning Trajectories
-
Omics in Hepatocellular
-
ESM1 drives cancer angiogenesis and bevacizumab resistance via trioleate synthesis
Neoplasia. 2026 May;75:101298. doi: 10.1016/j.neo.2026.101298. Epub 2026 Mar 20.ABSTRACTBACKGROUND: Hepatocellular carcinoma (HCC) exhibits high recurrence rates and limited therapeutic options. Endothelial cell-specific molecule 1 (ESM1) and angiopoietin-like 4 (ANGPTL4) are implicated in tumor progression, yet their synergistic role in HCC lipid metabolism and angiogenesis remains unexplored.METHODS: We integrated multi-omics approaches, including RNA sequencing, metabolomics, and immunoprecip
ESM1 drives cancer angiogenesis and bevacizumab resistance via trioleate synthesis
Neoplasia. 2026 May;75:101298. doi: 10.1016/j.neo.2026.101298. Epub 2026 Mar 20.
ABSTRACT
BACKGROUND: Hepatocellular carcinoma (HCC) exhibits high recurrence rates and limited therapeutic options. Endothelial cell-specific molecule 1 (ESM1) and angiopoietin-like 4 (ANGPTL4) are implicated in tumor progression, yet their synergistic role in HCC lipid metabolism and angiogenesis remains unexplored.
METHODS: We integrated multi-omics approaches, including RNA sequencing, metabolomics, and immunoprecipitation-mass spectrometry, in HCC cell lines and patient-derived xenograft models. Key experiments involved Co-IP, Western blotting, tube formation assays, and clinical tissue microarray analysis to validate the ESM1-ANGPTL4-FASN-trioleate axis.
RESULTS: ESM1 and ANGPTL4 formed a positive feedback loop, stabilizing fatty acid synthase (FASN) to promote trioleate synthesis. Trioleate activated the NF-κB/IL-17 pathway in HCC cells and upregulated CD99 in endothelial cells, driving angiogenesis. In vivo, ESM1/ANGPTL4 knockdown suppressed tumor growth, which was rescued by trioleate supplementation. Clinical data revealed elevated ESM1/ANGPTL4 expression in bevacizumab-resistant HCC, correlating with poor prognosis.
CONCLUSIONS: The ESM1-ANGPTL4-FASN-trioleate axis orchestrates metabolic reprogramming and endothelial activation, representing a promising therapeutic target. Future studies should explore combination therapies targeting this axis and overcoming bevacizumab resistance in HCC.
PMID:41864037 | PMC:PMC13019581 | DOI:10.1016/j.neo.2026.101298
-
cs.AI, q-bio.NC updates on arXiv.org
-
Sim2Sea: Sim-to-Real Policy Transfer for Maritime Vessel Navigation in Congested Waters
arXiv:2603.04057v1 Announce Type: cross Abstract: Autonomous navigation in congested maritime environments is a critical capability for a wide range of real-world applications. However, it remains an unresolved challenge due to complex vessel interactions and significant environmental uncertainties. Existing methods often fail in practical deployment due to a substantial sim-to-real gap, which stems from imprecise simulation, inadequate situational awareness, and unsafe exploration strategies.
Sim2Sea: Sim-to-Real Policy Transfer for Maritime Vessel Navigation in Congested Waters
-
cs.AI, q-bio.NC updates on arXiv.org
-
Structure-Level Disentangled Diffusion for Few-Shot Chinese Font Generation
arXiv:2602.18874v1 Announce Type: cross Abstract: Few-shot Chinese font generation aims to synthesize new characters in a target style using only a handful of reference images. Achieving accurate content rendering and faithful style transfer requires effective disentanglement between content and style. However, existing approaches achieve only feature-level disentanglement, allowing the generator to re-entangle these features, leading to content distortion and degraded style fidelity. We propos