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CoRe-Code: Collaborative Reinforcement Learning for Code Generation

arXiv:2605.24812v1 Announce Type: new Abstract: Large language models (LLMs) have achieved strong performance in code generation, but most methods rely on autoregressive decoding without global planning, often leading to locally coherent yet globally suboptimal solutions (e.g., failing test cases or inefficient complexity). While recent approaches such as Chain-of-Thought (CoT) and multi-agent systems (MAS) introduce planning, their limited role specialization and coordination hinder performance on complex tasks. To address the challenges of coordination and specialization in multi-agent code generation, we propose Collaborative Reinforcement Code (CoRe-Code), a framework for role specialized LLM agents that enhances inter-agent coordination to generate more accurate and efficient code. CoRe-Code adopts a simple Planner-Coder paradigm, where the Planner produces high-level plans and the Coder executes them to generate code. We further introduce a collaboration-aware reinforcement learning stage based on Group Relative Policy Optimization (GRPO) to enhance role specialization and alignment. Experiments show that CoRe-Code outperforms a wide range of existing RL-based and multi-agent methods. In addition, we demonstrate that CoRe-Code can generalize to other multi-agent frameworks (e.g., Retrieval and Debugging agents), highlighting its flexibility and scalability. We evaluate CoRe-Code on multiple benchmarks of varying difficulty using three base models. Compared to existing baselines, the results show consistent improvements in accuracy, while also achieving higher efficiency in terms of execution time and memory usage, demonstrating the effectiveness and practicality of CoRe-Code.

SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer

Oncogenesis, Published online: 13 April 2026; doi:10.1038/s41389-026-00614-4

SREBP2 regulates CCDC25 expression and promotes tumor metastasis in Triple-Negative Breast Cancer

Chain-of-Authorization: Internalizing Authorization into Large Language Models via Reasoning Trajectories

arXiv:2603.22869v1 Announce Type: new Abstract: Large Language Models (LLMs) have become core cognitive components in modern artificial intelligence (AI) systems, combining internal knowledge with external context to perform complex tasks. However, LLMs typically treat all accessible data indiscriminately, lacking inherent awareness of knowledge ownership and access boundaries. This deficiency heightens risks of sensitive data leakage and adversarial manipulation, potentially enabling unauthorized system access and severe security crises. Existing protection strategies rely on rigid, uniform defense that prevent dynamic authorization. Structural isolation methods faces scalability bottlenecks, while prompt guidance methods struggle with fine-grained permissions distinctions. Here, we propose the Chain-of-Authorization (CoA) framework, a secure training and reasoning paradigm that internalizes authorization logic into LLMs' core capabilities. Unlike passive external defneses, CoA restructures the model's information flow: it embeds permission context at input and requires generating explicit authorization reasoning trajectory that includes resource review, identity resolution, and decision-making stages before final response. Through supervised fine-tuning on data covering various authorization status, CoA integrates policy execution with task responses, making authorization a causal prerequisite for substantive responses. Extensive evaluations show that CoA not only maintains comparable utility in authorized scenarios but also overcomes the cognitive confusion when permissions mismatches. It exhibits high rejection rates against various unauthorized and adversarial access. This mechanism leverages LLMs' reasoning capability to perform dynamic authorization, using natural language understanding as a proactive security mechanism for deploying reliable LLMs in modern AI systems.

ESM1 drives cancer angiogenesis and bevacizumab resistance via trioleate synthesis

Neoplasia. 2026 May;75:101298. doi: 10.1016/j.neo.2026.101298. Epub 2026 Mar 20.

ABSTRACT

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits high recurrence rates and limited therapeutic options. Endothelial cell-specific molecule 1 (ESM1) and angiopoietin-like 4 (ANGPTL4) are implicated in tumor progression, yet their synergistic role in HCC lipid metabolism and angiogenesis remains unexplored.

METHODS: We integrated multi-omics approaches, including RNA sequencing, metabolomics, and immunoprecipitation-mass spectrometry, in HCC cell lines and patient-derived xenograft models. Key experiments involved Co-IP, Western blotting, tube formation assays, and clinical tissue microarray analysis to validate the ESM1-ANGPTL4-FASN-trioleate axis.

RESULTS: ESM1 and ANGPTL4 formed a positive feedback loop, stabilizing fatty acid synthase (FASN) to promote trioleate synthesis. Trioleate activated the NF-κB/IL-17 pathway in HCC cells and upregulated CD99 in endothelial cells, driving angiogenesis. In vivo, ESM1/ANGPTL4 knockdown suppressed tumor growth, which was rescued by trioleate supplementation. Clinical data revealed elevated ESM1/ANGPTL4 expression in bevacizumab-resistant HCC, correlating with poor prognosis.

CONCLUSIONS: The ESM1-ANGPTL4-FASN-trioleate axis orchestrates metabolic reprogramming and endothelial activation, representing a promising therapeutic target. Future studies should explore combination therapies targeting this axis and overcoming bevacizumab resistance in HCC.

PMID:41864037 | PMC:PMC13019581 | DOI:10.1016/j.neo.2026.101298

Sim2Sea: Sim-to-Real Policy Transfer for Maritime Vessel Navigation in Congested Waters

arXiv:2603.04057v1 Announce Type: cross Abstract: Autonomous navigation in congested maritime environments is a critical capability for a wide range of real-world applications. However, it remains an unresolved challenge due to complex vessel interactions and significant environmental uncertainties. Existing methods often fail in practical deployment due to a substantial sim-to-real gap, which stems from imprecise simulation, inadequate situational awareness, and unsafe exploration strategies. To address these, we propose \textbf{Sim2Sea}, a comprehensive framework designed to bridge simulation and real-world execution. Sim2Sea advances in three key aspects. First, we develop a GPU-accelerated parallel simulator for scalable and accurate maritime scenario simulation. Second, we design a dual-stream spatiotemporal policy that handles complex dynamics and multi-modal perception, augmented with a velocity-obstacle-guided action masking mechanism to ensure safe and efficient exploration. Finally, a targeted domain randomization scheme helps bridge the sim-to-real gap. Simulation results demonstrate that our method achieves faster convergence and safer trajectories than established baselines. In addition, our policy trained purely in simulation successfully transfers zero-shot to a 17-ton unmanned vessel operating in real-world congested waters. These results validate the effectiveness of Sim2Sea in achieving reliable sim-to-real transfer for practical autonomous maritime navigation.

Structure-Level Disentangled Diffusion for Few-Shot Chinese Font Generation

arXiv:2602.18874v1 Announce Type: cross Abstract: Few-shot Chinese font generation aims to synthesize new characters in a target style using only a handful of reference images. Achieving accurate content rendering and faithful style transfer requires effective disentanglement between content and style. However, existing approaches achieve only feature-level disentanglement, allowing the generator to re-entangle these features, leading to content distortion and degraded style fidelity. We propose the Structure-Level Disentangled Diffusion Model (SLD-Font), which receives content and style information from two separate channels. SimSun-style images are used as content templates and concatenated with noisy latent features as the input. Style features extracted by a CLIP model from target-style images are integrated via cross-attention. Additionally, we train a Background Noise Removal module in the pixel space to remove background noise in complex stroke regions. Based on theoretical validation of disentanglement effectiveness, we introduce a parameter-efficient fine-tuning strategy that updates only the style-related modules. This allows the model to better adapt to new styles while avoiding overfitting to the reference images' content. We further introduce the Grey and OCR metrics to evaluate the content quality of generated characters. Experimental results show that SLD-Font achieves significantly higher style fidelity while maintaining comparable content accuracy to existing state-of-the-art methods.
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