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Spatial evolution of a cachexia-promoting microenvironment in pancreatic cancer

Cell. 2026 Sep 29:S0092-8674(26)01081-0. doi: 10.1016/j.cell.2026.09.012. Online ahead of print.

ABSTRACT

Cachexia is a major cause of morbidity in pancreatic cancer, but the cellular circuitry linking tumor progression to systemic wasting remains incompletely understood. Integrating single-cell RNA sequencing, Xenium spatial transcriptomics, multiplex immunohistochemistry, bulk transcriptomics, and functional studies across human non-cachexia, pre-cachexia, and cachexia samples, together with mouse models, we define a cachexia-associated microenvironmental niche composed of SEMA4A+ tumor cells, AQP9+ macrophages, and LOXL2+ cancer-associated fibroblasts. Mechanistically, SEMA4A-associated signaling promotes bone morphogenetic protein-2 (BMP2)-dependent acquisition of an AQP9-associated macrophage phenotype, and macrophage-derived CXCL8 activates LOXL2+ fibroblasts. LOXL2+ fibroblasts reciprocally enhance tumor cell FOSL1/SEMA4A signaling through exosomal N-glycosylated LOXL2. Spatial analyses demonstrate progressive enrichment of this niche with cachexia severity and association with postoperative development of cachexia in previously non-cachectic patients. These findings provide a framework linking local tumor ecosystem dynamics to cachexia progression.

PMID:42810340 | DOI:10.1016/j.cell.2026.09.012

AssetOpsBench: Benchmarking AI Agents for Task Automation in Industrial Asset Operations and Maintenance

arXiv:2506.03828v3 Announce Type: replace Abstract: AI for Industrial Asset Lifecycle Management aims to automate complex operational workflows, such as condition monitoring and maintenance scheduling, to minimize system downtime. While traditional AI/ML approaches solve narrow tasks in isolation, Large Language Model (LLM) agents offer a next-generation opportunity for end-to-end automation. In this paper, we introduce AssetOpsBench, a unified framework for orchestrating and evaluating domain-specific agents for Industry 4.0. AssetOpsBench provides a multimodal ecosystem comprising a catalog of four domain-specific agents, a curated dataset of 140+ human-authored natural-language queries grounded in real industrial scenarios, and a simulated, CouchDB-backed IoT environment. We introduce an automated evaluation framework that uses three key metrics to analyze architectural trade-offs between the Tool-As-Agent and Plan-Executor paradigms, along with a systematic procedure for the automated discovery of emerging failure modes. The practical relevance of AssetOpsBench is demonstrated by its broad community adoption, with 250+ users and over 500 agents submitted to our public benchmarking platform, supporting reproducible and scalable research for real-world industrial operations. The code is accesible at https://github.com/IBM/AssetOpsBench .

Robot-Assisted Therapy for Upper Limb Rehabilitation After Stroke: Umbrella Review

Background: Stroke is a leading cause of long-term upper limb disability, severely impacting patients’ independence and quality of life. Robot-assisted therapy (RAT) has emerged as a promising, high-intensity rehabilitation alternative. However, conclusions from existing systematic reviews on its efficacy are inconsistent and often lack a holistic framework, limiting their use for guiding personalized clinical decisions. Objective: This study aims to systematically synthesize recent evidence on RAT for upper limb rehabilitation after stroke. Guided by the International Classification of Functioning, Disability and Health framework, it moves beyond singular outcomes to provide a multidimensional evaluation across body function, activity, and participation levels. The review aims to provide stratified guidance for clinical decision-making based on patient- and intervention-specific characteristics, thereby supporting evidence-based practice and informing future research. Methods: This study included systematic reviews and meta-analyses published from January 1, 2019, to December 26, 2025, comparing RAT with conventional therapy for upper limb rehabilitation after stroke. Overall, 6 databases, including PubMed, Web of Science, and Embase, were searched. Two reviewers (XZ and LZ) independently performed study selection, data extraction, and quality assessment using the AMSTAR 2 tool. The synthesis integrated outcome measures and subgroup analyses derived from the included studies. Results: This umbrella review included 21 meta-analyses encompassing 535 randomized controlled trials and 27,598 patients across acute, subacute, and chronic stroke stages. According to AMSTAR 2, 17 reviews were high quality, 3 moderate, and 1 critically low. The synthesis demonstrated that RAT was superior in improving upper limb motor function, but no statistically significant advantages were observed in activities of daily living compared to conventional therapy. Subgroup analyses revealed that treatment effects were influenced by stroke stage, upper limb motor impairment level, and robot type. Conclusions: RAT is an effective intervention for improving upper limb motor function after stroke. However, its benefits are primarily observed at the level of body function, with limited evidence for long-term maintenance. The current evidence is constrained by significant outcome heterogeneity and methodological limitations inherent to umbrella reviews. Future research should validate these findings in broader clinical practice, focus on translating functional gains into sustained improvements in daily activities and participation, and include cost-effectiveness evaluations. Trial Registration: PROSPERO CRD42024497183; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024497183

Dynamic Fusion-Aware Graph Convolutional Neural Network for Multimodal Emotion Recognition in Conversations

arXiv:2603.22345v1 Announce Type: new Abstract: Multimodal emotion recognition in conversations (MERC) aims to identify and understand the emotions expressed by speakers during utterance interaction from multiple modalities (e.g., text, audio, images, etc.). Existing studies have shown that GCN can improve the performance of MERC by modeling dependencies between speakers. However, existing methods usually use fixed parameters to process multimodal features for different emotion types, ignoring the dynamics of fusion between different modalities, which forces the model to balance performance between multiple emotion categories, thus limiting the model's performance on some specific emotions. To this end, we propose a dynamic fusion-aware graph convolutional neural network (DF-GCN) for robust recognition of multimodal emotion features in conversations. Specifically, DF-GCN integrates ordinary differential equations into graph convolutional networks (GCNs) to {capture} the dynamic nature of emotional dependencies within utterance interaction networks and leverages the prompts generated by the global information vector (GIV) of the utterance to guide the dynamic fusion of multimodal features. This allows our model to dynamically change parameters when processing each utterance feature, so that different network parameters can be equipped for different emotion categories in the inference stage, thereby achieving more flexible emotion classification and enhancing the generalization ability of the model. Comprehensive experiments conducted on two public multimodal conversational datasets {confirm} that the proposed DF-GCN model delivers superior performance, benefiting significantly from the dynamic fusion mechanism introduced.

From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents

arXiv:2603.22386v1 Announce Type: new Abstract: Large language model (LLM)-based systems are becoming increasingly popular for solving tasks by constructing executable workflows that interleave LLM calls, information retrieval, tool use, code execution, memory updates, and verification. This survey reviews recent methods for designing and optimizing such workflows, which we treat as agentic computation graphs (ACGs). We organize the literature based on when workflow structure is determined, where structure refers to which components or agents are present, how they depend on each other, and how information flows between them. This lens distinguishes static methods, which fix a reusable workflow scaffold before deployment, from dynamic methods, which select, generate, or revise the workflow for a particular run before or during execution. We further organize prior work along three dimensions: when structure is determined, what part of the workflow is optimized, and which evaluation signals guide optimization (e.g., task metrics, verifier signals, preferences, or trace-derived feedback). We also distinguish reusable workflow templates, run-specific realized graphs, and execution traces, separating reusable design choices from the structures actually deployed in a given run and from realized runtime behavior. Finally, we outline a structure-aware evaluation perspective that complements downstream task metrics with graph-level properties, execution cost, robustness, and structural variation across inputs. Our goal is to provide a clear vocabulary, a unified framework for positioning new methods, a more comparable view of existing body of literature, and a more reproducible evaluation standard for future work in workflow optimizations for LLM agents.

Evidence-Driven Reasoning for Industrial Maintenance Using Heterogeneous Data

arXiv:2603.08171v1 Announce Type: new Abstract: Industrial maintenance platforms contain rich but fragmented evidence, including free-text work orders, heterogeneous operational sensors or indicators, and structured failure knowledge. These sources are often analyzed in isolation, producing alerts or forecasts that do not support conditional decision-making: given this asset history and behavior, what is happening and what action is warranted? We present Condition Insight Agent, a deployed decision-support framework that integrates maintenance language, behavioral abstractions of operational data, and engineering failure semantics to produce evidence-grounded explanations and advisory actions. The system constrains reasoning through deterministic evidence construction and structured failure knowledge, and applies a rule-based verification loop to suppress unsupported conclusions. Case studies from production CMMS deployments show that this verification-first design operates reliably under heterogeneous and incomplete data while preserving human oversight. Our results demonstrate how constrained LLM-based reasoning can function as a governed decision-support layer for industrial maintenance.

Unified Medical Image Segmentation with State Space Modeling Snake

arXiv:2507.12760v2 Announce Type: replace-cross Abstract: Unified Medical Image Segmentation (UMIS) is critical for comprehensive anatomical assessment but faces challenges due to multi-scale structural heterogeneity. Conventional pixel-based approaches, lacking object-level anatomical insight and inter-organ relational modeling, struggle with morphological complexity and feature conflicts, limiting their efficacy in UMIS. We propose Mamba Snake, a novel deep snake framework enhanced by state space modeling for UMIS. Mamba Snake frames multi-contour evolution as a hierarchical state space atlas, effectively modeling macroscopic inter-organ topological relationships and microscopic contour refinements. We introduce a snake-specific vision state space module, the Mamba Evolution Block (MEB), which leverages effective spatiotemporal information aggregation for adaptive refinement of complex morphologies. Energy map shape priors further ensure robust long-range contour evolution in heterogeneous data. Additionally, a dual-classification synergy mechanism is incorporated to concurrently optimize detection and segmentation, mitigating under-segmentation of microstructures in UMIS. Extensive evaluations across five clinical datasets reveal Mamba Snake's superior performance, with an average Dice improvement of 3\% over state-of-the-art methods.

Rethinking Driving World Model as Synthetic Data Generator for Perception Tasks

arXiv:2510.19195v4 Announce Type: replace-cross Abstract: Recent advancements in driving world models enable controllable generation of high-quality RGB videos or multimodal videos. Existing methods primarily focus on metrics related to generation quality and controllability. However, they often overlook the evaluation of downstream perception tasks, which are $\mathbf{really\ crucial}$ for the performance of autonomous driving. Existing methods usually leverage a training strategy that first pretrains on synthetic data and finetunes on real data, resulting in twice the epochs compared to the baseline (real data only). When we double the epochs in the baseline, the benefit of synthetic data becomes negligible. To thoroughly demonstrate the benefit of synthetic data, we introduce Dream4Drive, a novel synthetic data generation framework designed for enhancing the downstream perception tasks. Dream4Drive first decomposes the input video into several 3D-aware guidance maps and subsequently renders the 3D assets onto these guidance maps. Finally, the driving world model is fine-tuned to produce the edited, multi-view photorealistic videos, which can be used to train the downstream perception models. Dream4Drive enables unprecedented flexibility in generating multi-view corner cases at scale, significantly boosting corner case perception in autonomous driving. To facilitate future research, we also contribute a large-scale 3D asset dataset named DriveObj3D, covering the typical categories in driving scenarios and enabling diverse 3D-aware video editing. We conduct comprehensive experiments to show that Dream4Drive can effectively boost the performance of downstream perception models under various training epochs. Page: https://wm-research.github.io/Dream4Drive/ GitHub Link: https://github.com/wm-research/Dream4Drive

ReportLogic: Evaluating Logical Quality in Deep Research Reports

arXiv:2602.18446v1 Announce Type: cross Abstract: Users increasingly rely on Large Language Models (LLMs) for Deep Research, using them to synthesize diverse sources into structured reports that support understanding and action. In this context, the practical reliability of such reports hinges on logical quality: whether the report's claims and arguments are explicitly supported and can be trusted as a basis for downstream use, rather than merely appearing fluent or informative. However, current evaluation frameworks largely overlook this requirement. To bridge this gap, we introduce ReportLogic, a benchmark that quantifies report-level logical quality through a reader-centric lens of auditability. Specifically, ReportLogic adopts a hierarchical taxonomy that evaluates whether readers can (1) trace an on-topic report structure with a unified analytical arc (Macro-Logic), (2) understand the progression with necessary context (Expositional-Logic), and (3) verify conclusions via explicit claim--support (Structural-Logic). Based on this taxonomy, we construct a human-annotated rubric-guided dataset and train an open-source LogicJudge for scalable evaluation. We further evaluate judge robustness via adversarial attacks, showing that off-the-shelf LLM judges are frequently influenced by superficial cues (e.g., verbosity), and reasoning modes can mask broken support relations. Overall, our results provide actionable guidance for building more robust logic evaluators and improving the logical reliability of LLM-generated reports.

RV-Syn: Rational and Verifiable Mathematical Reasoning Data Synthesis based on Structured Function Library

arXiv:2504.20426v3 Announce Type: replace Abstract: The advancement of reasoning capabilities in Large Language Models (LLMs) requires substantial amounts of high-quality reasoning data, particularly in mathematics. Existing data synthesis methods, such as data augmentation from annotated training sets or direct question generation based on relevant knowledge points and documents, have expanded datasets but face challenges in mastering the inner logic of the problem during generation and ensuring the verifiability of the solutions. To address these issues, we propose RV-Syn, a novel Rational and Verifiable mathematical Synthesis approach. RV-Syn constructs a structured mathematical operation function library based on initial seed problems and generates computational graphs as solutions by combining Python-formatted functions from this library. These graphs are then back-translated into complex problems. Based on the constructed computation graph, we achieve solution-guided logic-aware problem generation. Furthermore, the executability of the computational graph ensures the verifiability of the solving process. Experimental results show that RV-Syn surpasses existing synthesis methods, including those involving human-generated problems, achieving greater efficient data scaling. This approach provides a scalable framework for generating high-quality reasoning datasets.
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