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A governance horizon for ethical-use constraints in open-weight AI models

arXiv:2605.24383v1 Announce Type: new Abstract: Ethical constraints on open-weight AI models are both a reflection of societal concerns and a foundation for AI governance policy. They are expected to propagate to downstream derivatives while implemented as voluntary metadata disclosures that must be restated at each generation of reuse. We audit 2,142,823 model repositories on Hugging Face Hub to test whether this disclosure-based governance infrastructure can sustain traceability across deep model lineages. Restriction evidence decays with a half-life of 1.31 derivation steps ($R^2$=0.98), and beyond seven downstream generations at least 80% of descendant models lack sufficient public evidence for a governance determination, a depth boundary we formalize as the governance horizon. Platform-level interventions to restore missing licence metadata reveal that policy design (not enforcement alone) is the binding factor: inheritance-only designs require near-complete enforcement to move the horizon, whereas a mandatory-declaration design that explicitly resolves orphan lineage components shifts the horizon already at moderate enforcement. The structural bottleneck is lineages with no inheritable upstream intent: such orphan components remain undecidable under any inheritance-only policy regardless of enforcement rate, and unresolved upstream nodes additionally create direct downstream undecidability bottlenecks that inheritance rules alone cannot recover. Comparison with PyPI, where governance signals are carried by explicit machine-readable declarations, corroborates that the collapse is topology-specific to open-weight derivation rather than inherent to open ecosystems. These results establish that disclosure-based governance has a shallow, structurally determined reach in open-weight AI, and that achieving deep supply-chain accountability requires provenance mechanisms propagating governance signals through derivation itself.

Multi-omics analysis of BTF3L4 as a prognostic and immune biomarker in hepatocellular carcinoma

12 March 2026 at 18:00

Transl Cancer Res. 2026 Feb 28;15(2):77. doi: 10.21037/tcr-2025-aw-2179. Epub 2026 Feb 11.

ABSTRACT

BACKGROUND: Hepatocellular carcinoma (HCC) exhibits notable characteristics, encompassing frequent recurrence, weak immunotherapeutic outcomes and unfavorable prognosis. BTF3L4 has been identified as a critical factor in the progression of various malignancies. However, its specific role in HCC remains to be elucidated. This investigation sought to examine BTF3L4 levels in HCC and BTF3L4's connection with clinical prognosis and immune infiltration.

METHODS: We performed an extensive multi-omics evaluation in the course of our research. Bioinformatics tools were utilized to assess BTF3L4 messenger RNA (mRNA) expression in HCC. Multiplex immunohistochemistry (mIHC) was utilized to examine BTF3L4 protein expression and to explore its correlation with tumor-infiltrating immune cells (TIICs). Cox regression analysis and Kaplan-Meier survival curves were applied to determine BTF3L4's impact on patient outcomes.

RESULTS: Our analysis revealed markedly elevated levels of both BTF3L4 mRNA and protein in HCC tissues. BTF3L4 protein abundance emerged as an independent predictor of reduced survival in patients with HCC. Furthermore, elevated BTF3L4 protein expression was positively associated with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) expression and markedly negatively correlated with CD4+ T cells and CD66b+ neutrophils in HCC tissues.

CONCLUSIONS: This evidence indicates that BTF3L4 functions as a predictive indicator and is a potential candidate for HCC immunotherapy.

PMID:41815168 | PMC:PMC12971597 | DOI:10.21037/tcr-2025-aw-2179

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