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Inhalable carrier-free self-assembled leonurine-ursolic acid nanoaggregates ameliorate acute lung injury by suppressing TLR4/MyD88-NET axis

Mater Today Bio. 2026 Aug 18;40:103583. doi: 10.1016/j.mtbio.2026.103583. eCollection 2026 Oct.

ABSTRACT

TLR4 activation and the cascade of neutrophil extracellular trap (NET) formation exacerbate excessive inflammation and organ damage in the pathogenesis of acute lung injury (ALI), yet effective pharmacological interventions remain unavailable. Nanoaggregates derived from natural products offer promising avenue by leveraging synergistic anti-inflammatory effects. In this study, we surprisingly discovered that leonurine and ursolic acid spontaneously self-assemble into nanoparticles (LUNP) through non-covalent interactions, achieving a drug loading capacity of 100%. The LUNP platform exhibits superior biophysical properties, including enhanced mucus penetration, pH-responsive drug release, improved cellular uptake, and prolonged retention within inflamed lung tissue. Mechanistically, LUNP ameliorates ALI by dampening TLR4/MyD88/NF-κB-driven inflammatory activation, thereby remodeling the microenvironment to limit NOX4-PAD4-mediated NET formation. Notably, inhalational LUNP exhibits outstanding biosafety with minimal off-target distribution. Overall, this work introduces a synergistic self-assembled nanoplatform for precise pulmonary intervention in ALI, showcasing its ability to safely and effectively orchestrate the coordinated modulation of multiple pathological pathways. In summary, by inhibiting both TLR4 activation and NET formation, the synergistic LUNP platform offers an efficient, safe, and easily accessible therapeutic strategy for ALI, providing a promising solution for clinical translation.

PMID:42750707 | PMC:PMC13577835 | DOI:10.1016/j.mtbio.2026.103583

Scaling Online Complex Event Detection with Synthetic Supervision and Mamba-Based Neural Algorithmic Reasoning

arXiv:2502.07250v3 Announce Type: replace-cross Abstract: Modern machine learning models excel at detecting individual actions, sounds, or scene attributes from short, localized observations. However, many real-world tasks, such as in smart cities and healthcare, require reasoning over high-level complex events (CEs): spatiotemporal, rule-governed patterns of short-term atomic events (AEs). Complex event detection (CED) is challenging due to long temporal dependencies, generalization beyond the training horizon, sparse CE-level supervision without temporally aligned fine-grained AE labels, and cognitively demanding annotation, as CE labels often depend on ordering, duration, negation, and completion-time semantics. These challenges are further amplified in an online setting that requires causal, streaming inference with limited computation. We identify the primary bottleneck in online CED as learning robust CE rules, and propose a Neural Algorithmic Reasoning framework that decouples rule learning from low-level sensor semantics by (i) generating large-scale synthetic AE-level concept traces to pretrain a Mamba-based CE-rule reasoner, and (ii) introducing an adapter that learns to map raw sensor inputs into the reasoner's latent space using limited, labeled sensor data. We introduce a controlled simulator-generated online multilabel CED testbed built from real-world multimodal sensor clips and rule-generated CE labels, with stress-test settings that vary sensor noise, distribution shift, and the window size used to segment streaming sensor sequences. Experiments on this controlled benchmark show that NAROCE is competitive with the strongest baselines and often outperforms them under these stress tests and longer-horizon generalization, while using 5x fewer labeled sensor sequences and 10-20x fewer FLOPs than all non-Mamba baselines. Code and dataset available at https://github.com/nesl/naroce_dailyoce.

When the Manual Lies: A Realistic Benchmark to Evaluate MCP Poisoning Attacks for LLM Agents

arXiv:2605.24069v1 Announce Type: cross Abstract: The rise of tool-using Large Language Model (LLM) agents, standardized by protocols like the Model Context Protocol (MCP), has unlocked unprecedented autonomous execution capabilities for LLM Agents by integrating external open-domain knowledge and tools. However, this interoperability introduces a covert attack surface targeting the agent's cognitive planning layer. This paper systematically investigates Tool Description Poisoning (TDP), a novel semantic attack. In TDP, malicious instructions are not embedded in a tool's executable code, but rather covertly injected into its descriptive metadata, the very "manual" an agent relies on for secure planning and decision-making. To rigorously and systematically evaluate this emerging threat, we introduce the MCP-TDP Security Benchmark. This high-fidelity sandbox environment comprises 32 realistic, real-world test cases spanning 6 distinct risk categories. Our evaluation of 8 mainstream LLMs reveals severe vulnerabilities, with leading models like GPT-4o exhibiting a nearly 100% Attack Success Rate (ASR) in six high-risk scenarios. Furthermore, our findings demonstrate that common prompt-guardrail defenses are largely ineffective and can, counterintuitively, even be counterproductive (a phenomenon which we term the "Firewall Fallacy"). Crucially, we also propose a defense mechanism: "Reactive Self-Correction," where an agent autonomously detects and reverts its own malicious actions post-execution. This work provides the first specialized security benchmark tailored for TDP, offering essential insights for securing the cognitive and planning layers of advanced agentic systems.

TS-Skill: A Benchmark for Evaluating Analytical Skills in Time-Series Question Answering

arXiv:2605.24703v1 Announce Type: cross Abstract: Large language models (LLMs) and time-series language models (TSLMs) are increasingly applied to time-series question answering (TSQA). Unlike text-only QA, TSQA requires models to ground answers in temporal signals whose patterns may occur at different scales, specific time locations, or across separated intervals. However, existing benchmarks are typically organized by task types or high-level reasoning categories, making it difficult to diagnose the underlying signal-level capabilities driving model performance. We introduce TS-Skill, a controlled benchmark for evaluating three composable analytical skills in TSQA: temporal scale selection (SK1), temporal localization (SK2), and cross-interval integration (SK3). TS-Skill provides timestamp-aware questions, broad domain coverage, and human-validated QA quality. To construct the benchmark at scale, we develop SKEvol, a skill-guided agentic framework that combines domain-aware time-series seed generation, skill-controlled question generation, metadata- and code-assisted answer construction, multi-phase signal-grounded verification, and human-in-the-loop curation. Experiments on ten state-of-the-art LLMs and TSLMs reveal substantial and uneven capability gaps across SK1-SK3. In particular, SK3 remains consistently challenging for non-agent models, whereas tool-augmented agents show a selective advantage on standalone SK3. These findings demonstrate that skill-level evaluation can uncover temporal reasoning failures that are obscured by aggregate TSQA scores.

Evaluating AI in leukocyte classification: performance of the AI system against 15 morphology experts

npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02601-w

Evaluating AI in leukocyte classification: performance of the AI system against 15 morphology experts

FileGram: Grounding Agent Personalization in File-System Behavioral Traces

arXiv:2604.04901v1 Announce Type: cross Abstract: Coworking AI agents operating within local file systems are rapidly emerging as a paradigm in human-AI interaction; however, effective personalization remains limited by severe data constraints, as strict privacy barriers and the difficulty of jointly collecting multimodal real-world traces prevent scalable training and evaluation, and existing methods remain interaction-centric while overlooking dense behavioral traces in file-system operations; to address this gap, we propose FileGram, a comprehensive framework that grounds agent memory and personalization in file-system behavioral traces, comprising three core components: (1) FileGramEngine, a scalable persona-driven data engine that simulates realistic workflows and generates fine-grained multimodal action sequences at scale; (2) FileGramBench, a diagnostic benchmark grounded in file-system behavioral traces for evaluating memory systems on profile reconstruction, trace disentanglement, persona drift detection, and multimodal grounding; and (3) FileGramOS, a bottom-up memory architecture that builds user profiles directly from atomic actions and content deltas rather than dialogue summaries, encoding these traces into procedural, semantic, and episodic channels with query-time abstraction; extensive experiments show that FileGramBench remains challenging for state-of-the-art memory systems and that FileGramEngine and FileGramOS are effective, and by open-sourcing the framework, we hope to support future research on personalized memory-centric file-system agents.

Residual Decoding: Mitigating Hallucinations in Large Vision-Language Models via History-Aware Residual Guidance

arXiv:2602.01047v3 Announce Type: replace-cross Abstract: Large Vision-Language Models (LVLMs) can reason from image-text inputs and perform well in various multimodal tasks. Despite this success, they are affected by language priors and often produce hallucinations. Hallucinations denote generated content that is grammatically and syntactically coherent, yet bears no match or direct relevance to visual input. To address this problem, we propose Residual Decoding (ResDec). It is a novel training-free method that uses historical information to aid decoding. The method relies on the internal implicit reasoning mechanism and token logits evolution mechanism of LVLMs to correct biases. Extensive experiments demonstrate that ResDec effectively suppresses hallucinations induced by language priors, significantly improves visual grounding, and reduces object hallucinations. In addition to mitigating hallucinations, ResDec also performs exceptionally well on comprehensive LVLM benchmarks, highlighting its broad applicability.
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