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Received — 27 May 2026 ⏭

Nature - Issue - nature.com science feeds
Template-driven scaffolding of SCF<sup>FBXO42</sup> regulates PP2A degradation Sebastien Coassolo · Nairie Michaelian · Timurs Maculins · Caleigh M. Azumaya · Tommy K. Cheung · Jianping Yin · Inna Zilberleyb · Kanika Bajaj Pahuja · Thomas Garner · Ted Lau · Davis Mau · Matthew Grimmer · Jean-Philippe Fortin · Mike Costa · Yoana N. Dimitrova · Christopher M. Rose · Peter L. Hsu · Robert L. Yauch
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10368-zThe E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness
15 April 2026 at 08:00

Template-driven scaffolding of SCF<sup>FBXO42</sup> regulates PP2A degradation

Nature - Issue - nature.com science feeds

By: Sebastien Coassolo · Nairie Michaelian · Timurs Maculins · Caleigh M. Azumaya · Tommy K. Cheung · Jianping Yin · Inna Zilberleyb · Kanika Bajaj Pahuja · Thomas Garner · Ted Lau · Davis Mau · Matthew Grimmer · Jean-Philippe Fortin · Mike Costa · Yoana N. Dimitrova · Christopher M. Rose · Peter L. Hsu · Robert L. Yauch

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10368-z

The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness