arXiv:2605.24883v1 Announce Type: new Abstract: The widespread integration of Large Language Models (LLMs) necessitates rigorous and systematic safety evaluation. Existing paradigms either rely on constructed benchmarks to assess safety from predefined perspectives, or employ dynamic red-teaming to probe potential vulnerabilities. While effective, these approaches face challenges, as they depend heavily on expert domain knowledge, offer limited systematic guarantees, and are vulnerable to rapid obsolescence. To address these limitations, we introduce a novel framework POLARIS that brings the rigor of specification-based software testing to AI safety. POLARIS first compiles unstructured natural-language policies into First-Order Logic (FOL) representations, establishing a traceable link between high-level rules and concrete test cases. This formalization enables the construction of a Semantic Policy Graph, where complex policy violation scenarios are encoded as traversable paths. By systematically exploring this graph, POLARIS uncovers compositional violation patterns, which are then instantiated into executable natural-language test queries, enabling coverage-driven and reproducible safety testing. Experiments demonstrate that POLARIS achieves higher policy coverage and attack success counts compared to established baselines. Crucially, by bridging formal methods and AI safety, POLARIS provides a principled, automated approach to ensuring LLMs adhere to safety-critical policies with verifiable traceability. We release our code at https://github.com/huac-lxy/POLARIS.

arXiv:2605.26029v1 Announce Type: new Abstract: We introduce CausaLab, a scalable environment for evaluating interactive causal discovery by LLM agents. Unlike prior evaluations, CausaLab evaluates both whether an agent can solve a problem using causal evidence and whether its answer is supported by a correct hypothesis about the underlying causal mechanism. Each episode places an agent in a synthetic laboratory: it receives prior measurement records, intervenes on a manipulator crystal, and predicts the resonance frequency of a held-out reactor crystal governed by the same mechanism. The hidden data-generating process is a randomly sampled structural causal model (SCM), so success requires recovering both a causal graph and structural equations rather than recalling prior knowledge. CausaLab also includes a domain-specific language that records the agent's evolving SCM hypothesis, making trajectories inspectable and comparable with ground truth. Experiments show a persistent gap between prediction and mechanism recovery: in the purely observational 6-node setting, GPT-5.2-high reaches 92% task accuracy but only 0.471 all-edge $F_1$. This observation further motivates our exploration of different interaction strategies: Mixed observation--intervention strategies improve structural fidelity: in the mixed 6-node setting, GPT-5.2-high achieves 80% on both task accuracy and all-edge $F_1$. Yet even strong agents struggle to design informative interventions, as pure intervention strategies perform poorly on both task accuracy and all-edge $F_1$. We identify premature stopping as a major weakness of agents, and show that asking the model to verify the consistency between its hypothesis and past data can help mitigate this issue. CausaLab therefore separates predictive success from causal understanding and exposes current LLM agents' limits as experimental causal reasoners.

arXiv:2603.29897v2 Announce Type: replace-cross Abstract: Reranking is a critical component in many information retrieval pipelines. Despite remarkable progress in text-only settings, multimodal reranking remains challenging, particularly when the candidate set contains hybrid text and image items. A key difficulty is the modality gap: a text reranker is intrinsically closer to text candidates than to image candidates, leading to biased and suboptimal cross-modal ranking. Vision-language models (VLMs) mitigate this gap through strong cross-modal alignment and have recently been adopted to build multimodal rerankers. However, most VLM-based rerankers encode all candidates as images, and treating text as images introduces substantial computational overhead. Meanwhile, existing open-source multimodal rerankers are typically trained on general-domain data and often underperform in domain-specific scenarios. To address these limitations, we propose UniRank, a VLM-based reranking framework that natively scores and orders hybrid text-image candidates without any modality conversion. Building on this hybrid scoring interface, UniRank provides an end-to-end domain adaptation pipeline that includes: (1) an instruction-tuning stage that learns calibrated cross-modal relevance scoring by mapping label-token likelihoods to a unified scalar score; and (2) a hard-negative-driven preference alignment stage that constructs in-domain pairwise preferences and performs query-level policy optimization through reinforcement learning from human feedback (RLHF). Extensive experiments on scientific literature retrieval and design patent search demonstrate that UniRank consistently outperforms state-of-the-art baselines, improving Recall@1 by 8.9% and 7.3%, respectively.

arXiv:2605.10989v3 Announce Type: replace-cross Abstract: The training of Binary Neural Networks (BNNs) is fundamentally based on gradient approximation for non-differentiable binarization operations (e.g., sign function). However, prevailing methods including the Straight-Through Estimator (STE) and its improved variants, rely on hand-crafted designs that suffer from gradient mismatch problem and information loss induced by fixed-range gradient clipping. To address this, we propose SURrogate GradiEnt Adaptation (SURGE), a novel learnable gradient compensation framework with theoretical grounding. SURGE mitigates gradient mismatch through auxiliary backpropagation. Specifically, we design a Dual-Path Gradient Compensator (DPGC) that constructs a parallel full-precision auxiliary branch for each binarized layer, decoupling gradient flow via output decomposition during backpropagation. DPGC enables bias-reduced gradient estimation by leveraging the full-precision branch to estimate components beyond STE's first-order approximation. To further enhance training stability, we introduce an Adaptive Gradient Scaler (AGS) based on an optimal scale factor to dynamically balance inter-branch gradient contributions via norm-based scaling. Experiments on image classification, object detection, and language understanding tasks demonstrate that SURGE performs best over state-of-the-art methods.

arXiv:2605.23491v2 Announce Type: replace-cross Abstract: Recently, Reinforcement Learning with Verifiable Rewards (RLVR) and Test-Time Scaling (TTS) have advanced LLM code generation through executable verification. Yet Ground-Truth Unit Tests (GT UTs) remain a bottleneck: SOTA RLVR methods require them for costly training, while existing TTS methods lose competitiveness without them. This motivates GT-free TTS, where existing methods directly use self-generated UTs to refine and select code candidates. Yet such UTs are often noisy or spuriously coupled with wrong code, and UT quality in turn cannot be validated without reliable code. The key challenge is therefore to jointly improve both. To this end, we present CoSPlay, a GT-free, training-free framework that jointly improves codes and UTs through cooperative self-play. It first explores diverse solution ideas and identifies their potential failure modes to produce discriminative UT ideas. It then uses bidirectional pass-count signals from the Code-UT execution matrix to iteratively prune or fix weak codes and refresh or replace unreliable UTs, letting the two pools co-evolve. Finally, when multiple codes remain tied at the highest pass count, it picks the final code from the largest output-consensus cluster, since correct codes agree on the same inputs while wrong codes diverge. Experiments on four challenging benchmarks show that CoSPlay on Qwen2.5-7B-Instruct improves average BoN from 22.1% to 33.2% and UT accuracy from 14.6% to 78.3%, matching or surpassing the RLVR model CURE-7B. When applied to CURE-7B, it further improves BoN by 5.7%. CoSPlay also generalizes across diverse backbones and outperforms GT-free TTS baselines under comparable token budgets, with continued gains as the budget scales up. These results suggest a scalable inference strategy for competitive code generation without any GT data.

arXiv:2603.29897v1 Announce Type: cross Abstract: Reranking is a critical component in many information retrieval pipelines. Despite remarkable progress in text-only settings, multimodal reranking remains challenging, particularly when the candidate set contains hybrid text and image items. A key difficulty is the modality gap: a text reranker is intrinsically closer to text candidates than to image candidates, leading to biased and suboptimal cross-modal ranking. Vision-language models (VLMs) mitigate this gap through strong cross-modal alignment and have recently been adopted to build multimodal rerankers. However, most VLM-based rerankers encode all candidates as images, and treating text as images introduces substantial computational overhead. Meanwhile, existing open-source multimodal rerankers are typically trained on general-domain data and often underperform in domain-specific scenarios. To address these limitations, we propose UniRank, a VLM-based reranking framework that natively scores and orders hybrid text-image candidates without any modality conversion. Building on this hybrid scoring interface, UniRank provides an end-to-end domain adaptation pipeline that includes: (1) an instruction-tuning stage that learns calibrated cross-modal relevance scoring by mapping label-token likelihoods to a unified scalar score; and (2) a hard-negative-driven preference alignment stage that constructs in-domain pairwise preferences and performs query-level policy optimization through reinforcement learning from human feedback (RLHF). Extensive experiments on scientific literature retrieval and design patent search demonstrate that UniRank consistently outperforms state-of-the-art baselines, improving Recall@1 by 8.9% and 7.3%, respectively.

Nature Cancer, Published online: 10 March 2026; doi:10.1038/s43018-026-01127-0

Kelly et al. assessed an artificial intelligence system for breast cancer screening in retrospective datasets, followed by prospective feasibility evaluation, and report its accuracy, fairness and clinical implementation in multiple workflow settings.

Nature Cancer, Published online: 10 March 2026; doi:10.1038/s43018-026-01128-z

Warren et al. used data from a retrospective cohort of 50,000 women attending breast screening. Arbitration between human and AI decisions was performed in a reader study following normal arbitration workflow. After arbitration, replacing the second human reader with AI in a double-read breast screening workflow was noninferior to two human readers.

Cell Death Discovery, Published online: 07 March 2026; doi:10.1038/s41420-026-02953-y

TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease

arXiv:2603.04135v1 Announce Type: cross Abstract: Group Relative Policy Optimization (GRPO) effectively scales LLM reasoning but incurs prohibitive computational costs due to its extensive group-based sampling requirement. While recent selective data utilization methods can mitigate this overhead, they could induce estimation bias by altering the underlying sampling distribution, compromising theoretical rigor and convergence behavior. To address this limitation, we propose Dynamic Pruning Policy Optimization (DPPO), a framework that enables dynamic pruning while preserving unbiased gradient estimation through importance sampling-based correction. By incorporating mathematically derived rescaling factors, DPPO significantly accelerates GRPO training without altering the optimization objective of the full-batch baseline. Furthermore, to mitigate the data sparsity induced by pruning, we introduce Dense Prompt Packing, a window-based greedy strategy that maximizes valid token density and hardware utilization. Extensive experiments demonstrate that DPPO consistently accelerates training across diverse models and benchmarks. For instance, on Qwen3-4B trained on MATH, DPPO achieves 2.37$\times$ training speedup and outperforms GRPO by 3.36% in average accuracy across six mathematical reasoning benchmarks.

arXiv:2602.12705v3 Announce Type: replace-cross Abstract: We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous medical corpora to broaden knowledge coverage and reduce long-tail gaps (e.g., rare diseases). For medical expert-level reasoning and interaction, MedXIAOHE incorporates diverse medical reasoning patterns via reinforcement learning and tool-augmented agentic training, enabling multi-step diagnostic reasoning with verifiable decision traces. To improve reliability in real-world use, MedXIAOHE integrates user-preference rubrics, evidence-grounded reasoning, and low-hallucination long-form report generation, with improved adherence to medical instructions. We release this report to document our practical design choices, scaling insights, and evaluation framework, hoping to inspire further research.

arXiv:2602.19844v1 Announce Type: cross Abstract: LLM-enabled applications are rapidly reshaping the software ecosystem by using large language models as core reasoning components for complex task execution. This paradigm shift, however, introduces fundamentally new reliability challenges and significantly expands the security attack surface, due to the non-deterministic, learning-driven, and difficult-to-verify nature of LLM behavior. In light of these emerging and unavoidable safety challenges, we argue that such risks should be treated as expected operational conditions rather than exceptional events, necessitating a dedicated incident-response perspective. Consequently, the primary barrier to trustworthy deployment is not further improving model capability but establishing system-level threat monitoring mechanisms that can detect and contextualize security-relevant anomalies after deployment -- an aspect largely underexplored beyond testing or guardrail-based defenses. Accordingly, this position paper advocates systematic and comprehensive monitoring of security threats in LLM-enabled applications as a prerequisite for reliable operation and a foundation for dedicated incident-response frameworks.

arXiv:2602.14490v1 Announce Type: cross Abstract: Large Language Models (LLMs) have achieved remarkable progress, with Parameter-Efficient Fine-Tuning (PEFT) emerging as a key technique for downstream task adaptation. However, existing PEFT methods mainly operate in Euclidean space, fundamentally limiting their capacity to capture complex geometric structures inherent in language data. While alternative geometric spaces, like hyperbolic geometries for hierarchical data and spherical manifolds for circular patterns, offer theoretical advantages, forcing representations into a single manifold type ultimately limits expressiveness, even when curvature parameters are learnable. To address this, we propose Mixture of Space (MoS), a unified framework that leverages multiple geometric spaces simultaneously to learn richer, curvature-aware representations. Building on this scheme, we develop MoSLoRA, which extends Low-Rank Adaptation (LoRA) with heterogeneous geometric experts, enabling models to dynamically select or combine appropriate geometric spaces based on input context. Furthermore, to address the computational overhead of frequent manifold switching, we develop a lightweight routing mechanism. Moreover, we provide empirical insights into how curvature optimization impacts training stability and model performance. Our experiments across diverse benchmarks demonstrate that MoSLoRA consistently outperforms strong baselines, achieving up to 5.6% improvement on MATH500 and 15.9% on MAWPS.

arXiv:2602.12705v2 Announce Type: replace-cross Abstract: We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous medical corpora to broaden knowledge coverage and reduce long-tail gaps (e.g., rare diseases). For medical expert-level reasoning and interaction, MedXIAOHE incorporates diverse medical reasoning patterns via reinforcement learning and tool-augmented agentic training, enabling multi-step diagnostic reasoning with verifiable decision traces. To improve reliability in real-world use, MedXIAOHE integrates user-preference rubrics, evidence-grounded reasoning, and low-hallucination long-form report generation, with improved adherence to medical instructions. We release this report to document our practical design choices, scaling insights, and evaluation framework, hoping to inspire further research.