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Aleatoric Uncertainty Medical Image Segmentation Estimation via Flow Matching

arXiv:2507.22418v2 Announce Type: replace-cross Abstract: Quantifying aleatoric uncertainty in medical image segmentation is critical since it is a reflection of the natural variability observed among expert annotators. A conventional approach is to model the segmentation distribution using the generative model, but current methods limit the expression ability of generative models. While current diffusion-based approaches have demonstrated impressive performance in approximating the data distribution, their inherent stochastic sampling process and inability to model exact densities limit their effectiveness in accurately capturing uncertainty. In contrast, our proposed method leverages conditional flow matching, a simulation-free flow-based generative model that learns an exact density, to produce highly accurate segmentation results. By guiding the flow model on the input image and sampling multiple data points, our approach synthesizes segmentation samples whose pixel-wise variance reliably reflects the underlying data distribution. This sampling strategy captures uncertainties in regions with ambiguous boundaries, offering robust quantification that mirrors inter-annotator differences. Experimental results demonstrate that our method not only achieves competitive segmentation accuracy but also generates uncertainty maps that provide deeper insights into the reliability of the segmentation outcomes. The code for this paper is freely available at https://github.com/huynhspm/Data-Uncertainty

MedSteer: Counterfactual Endoscopic Synthesis via Training-Free Activation Steering

arXiv:2603.07066v1 Announce Type: cross Abstract: Generative diffusion models are increasingly used for medical imaging data augmentation, but text prompting cannot produce causal training data. Re-prompting rerolls the entire generation trajectory, altering anatomy, texture, and background. Inversion-based editing methods introduce reconstruction error that causes structural drift. We propose MedSteer, a training-free activation-steering framework for endoscopic synthesis. MedSteer identifies a pathology vector for each contrastive prompt pair in the cross-attention layers of a diffusion transformer. At inference time, it steers image activations along this vector, generating counterfactual pairs from scratch where the only difference is the steered concept. All other structure is preserved by construction. We evaluate MedSteer across three experiments on Kvasir v3 and HyperKvasir. On counterfactual generation across three clinical concept pairs, MedSteer achieves flip rates of 0.800, 0.925, and 0.950, outperforming the best inversion-based baseline in both concept flip rate and structural preservation. On dye disentanglement, MedSteer achieves 75% dye removal against 20% (PnP) and 10% (h-Edit). On downstream polyp detection, augmenting with MedSteer counterfactual pairs achieves ViT AUC of 0.9755 versus 0.9083 for quantity-matched re-prompting, confirming that counterfactual structure drives the gain. Code is at link https://github.com/phamtrongthang123/medsteer

Adaptive Collaboration of Arena-Based Argumentative LLMs for Explainable and Contestable Legal Reasoning

arXiv:2602.18916v1 Announce Type: cross Abstract: Legal reasoning requires not only high accuracy but also the ability to justify decisions through verifiable and contestable arguments. However, existing Large Language Model (LLM) approaches, such as Chain-of-Thought (CoT) and Retrieval-Augmented Generation (RAG), often produce unstructured explanations that lack a formal mechanism for verification or user intervention. To address this limitation, we propose Adaptive Collaboration of Argumentative LLMs (ACAL), a neuro-symbolic framework that integrates adaptive multi-agent collaboration with an Arena-based Quantitative Bipolar Argumentation Framework (A-QBAF). ACAL dynamically deploys expert agent teams to construct arguments, employs a clash resolution mechanism to adjudicate conflicting claims, and utilizes uncertainty-aware escalation for borderline cases. Crucially, our framework supports a Human-in-the-Loop (HITL) contestability workflow, enabling users to directly audit and modify the underlying reasoning graph to influence the final judgment. Empirical evaluations on the LegalBench benchmark demonstrate that ACAL outperforms strong baselines across Gemini-2.5-Flash-Lite and Gemini-2.5-Flash architectures, effectively balancing efficient predictive performance with structured transparency and contestability. Our implementation is available at: https://github.com/loc110504/ACAL.
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