Nature Biomedical Engineering, Published online: 10 September 2026; doi:10.1038/s41551-026-01810-8

Author Correction: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

arXiv:2508.08005v5 Announce Type: replace-cross Abstract: Although the Maximum Clique Problem (MCP) has been extensively studied and features a rich ecosystem of exact solvers, empirical evidence shows that solver performance varies substantially across graph families. Consequently, selecting an appropriate algorithm for a given instance remains an open and practically important challenge that has received little systematic attention. We address this gap by developing an instance-aware selection framework that systematically combines global statistical descriptors with learned topological representations. We construct a comprehensive benchmark by evaluating four state-of-the-art exact solvers on a diverse collection of graph instances and deriving both global statistical and local structural features. An evaluation of conventional classifiers establishes Random Forest as a strong baseline and reveals that connectivity and topological features are key predictors of performance. Motivated by these observations, we introduce a dual-channel architecture that jointly leverages a Graph Attention Network for capturing local neighborhood patterns and a Multilayer Perceptron for modeling global statistical features. Extensive experiments show that the proposed dual-channel model consistently surpasses classical baselines and the single-best solver, achieving 90.43% test accuracy. These findings demonstrate the value of integrating local topological encoding with global statistical cues for combinatorial algorithm selection. Code and models are available at: https://anonymous.4open.science/r/GAT-MLP-7E5F.

Nature Cancer, Published online: 25 August 2026; doi:10.1038/s43018-026-01241-z

Author Correction: Low-protein diet enhances antitumor immunity in pancreatic cancer through microbiota-derived UDP-galactose

arXiv:2605.25446v1 Announce Type: new Abstract: Electrocardiography (ECG) is central to cardiovascular care, but conventional AI models are often restricted to common arrhythmias and may generalize poorly across populations or clinically subtle diseases. We developed ECG Contrastive Language-Image Pre-training (ECGCLIP), a signal-language contrastive learning framework that aligns ECG waveforms with expert diagnostic reports. ECGCLIP was pre-trained on 2,837,962 ECG studies from 1,324,856 patients and evaluated on a held-out internal test set plus nine independent external cohorts comprising about 1.5 million ECGs. Evaluation covered 89 downstream tasks, including 45 ECG diagnoses, 39 echocardiographic targets, and 5 rare cardiac diseases, using PRAUC as the primary metric. ECGCLIP consistently improved performance over random initialization and Merl-R18 baselines. On the internal test set, ECGCLIP-R34 achieved strong performance for atrial fibrillation (PRAUC 0.900) and ST-segment elevation myocardial infarction (PRAUC 0.383), with robust generalization across all external cohorts. It also improved low-prevalence and diagnostically elusive diseases, including Ebstein anomaly, constrictive pericarditis, dextrocardia, and cardiac amyloidosis, with internal PRAUC values of 0.253, 0.175, 0.121, and 0.201, respectively. ECGCLIP was data efficient, matching or exceeding full-dataset baseline performance with only 10% of training data. Feature visualization and saliency analysis suggested clinically meaningful representations aligned with established electrocardiographic criteria. These findings indicate that large-scale ECG-report contrastive pre-training can expand routine ECG interpretation beyond common arrhythmias toward broad cardiovascular assessment and opportunistic screening of echocardiographic and rare conditions.

Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-w

Grand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.

arXiv:2512.03795v2 Announce Type: replace-cross Abstract: Autonomous Driving (AD) vehicles still struggle to exhibit human-like behavior in highly dynamic and interactive traffic scenarios. The key challenge lies in AD's limited ability to interact with surrounding vehicles, largely due to a lack of understanding the underlying mechanisms of social interaction. To address this issue, we introduce MPCFormer, an explainable socially-aware autonomous driving approach with physics-informed and data-driven coupled social interaction dynamics. In this model, the dynamics are formulated into a discrete space-state representation, which embeds physics priors to enhance modeling explainability. The dynamics coefficients are learned from naturalistic driving data via a Transformer-based encoder-decoder architecture. To the best of our knowledge, MPCFormer is the first approach to explicitly model the dynamics of multi-vehicle social interactions. The learned social interaction dynamics enable the planner to generate manifold, human-like behaviors when interacting with surrounding traffic. By leveraging the MPC framework, the approach mitigates the potential safety risks typically associated with purely learning-based methods. Open-looped evaluation on NGSIM dataset demonstrates that MPCFormer achieves superior social interaction awareness, yielding the lowest trajectory prediction errors compared with other state-of-the-art approaches. The prediction achieves an ADE as low as 0.86 m over a long prediction horizon of 5 seconds. Close-looped experiments in highly intense interaction scenarios, where consecutive lane changes are required to exit an off-ramp, further validate the effectiveness of MPCFormer. Results show that MPCFormer achieves the highest planning success rate of 94.67%, improves driving efficiency by 15.75%, and reduces the collision rate from 21.25% to 0.5%, outperforming a frontier Reinforcement Learning (RL) based planner.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.

arXiv:2506.17188v2 Announce Type: replace-cross Abstract: In this paper, we introduce the AI Search Paradigm, a comprehensive blueprint for next-generation search systems capable of emulating human information processing and decision-making. The paradigm employs a modular architecture of four LLM-powered agents (Master, Planner, Executor and Writer) that dynamically adapt to the full spectrum of information needs, from simple factual queries to complex multi-stage reasoning tasks. These agents collaborate dynamically through coordinated workflows to evaluate query complexity, decompose problems into executable plans, and orchestrate tool usage, task execution, and content synthesis. We systematically present key methodologies for realizing this paradigm, including task planning and tool integration, execution strategies, aligned and robust retrieval-augmented generation, and efficient LLM inference, spanning both algorithmic techniques and infrastructure-level optimizations. By providing an in-depth guide to these foundational components, this work aims to inform the development of trustworthy, adaptive, and scalable AI search systems.