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Received — 10 September 2026 ⏭

Molecular Therapy
Multivalent DNA vaccines induce potent cellular responses and prolong BCG-mediated control of Mycobacterium tuberculosis Elizabeth M. Parzych · Mamadou A. Bah · Nicholas J. Tursi · Ebony N. Gary · Ali R. Ali · Jacqueline D. Chu · Rianne N. Esquivel · Debra K. Duso · Matthew Cole · Larry Kummer · Alan Roberts · Tricia Hart · Shania E. Muncil · Trevor R.F. Smith · Ami Patel · William W. Reiley · David B. Weiner
Multivalent DNA plasmids, each encoding a diverse set of Mtb antigens, elicited robust polyfunctional T cell responses in naive and BCG-primed mice. Boosting with the lead construct, pESX, resulted in superior immunogenicity that correlated with prolonged pulmonary bacterial control in BCG-primed mice.
14 July 2026 at 08:00

Multivalent DNA vaccines induce potent cellular responses and prolong BCG-mediated control of Mycobacterium tuberculosis

By: Elizabeth M. Parzych · Mamadou A. Bah · Nicholas J. Tursi · Ebony N. Gary · Ali R. Ali · Jacqueline D. Chu · Rianne N. Esquivel · Debra K. Duso · Matthew Cole · Larry Kummer · Alan Roberts · Tricia Hart · Shania E. Muncil · Trevor R.F. Smith · Ami Patel · William W. Reiley · David B. Weiner

14 July 2026 at 08:00

Multivalent DNA plasmids, each encoding a diverse set of Mtb antigens, elicited robust polyfunctional T cell responses in naive and BCG-primed mice. Boosting with the lead construct, pESX, resulted in superior immunogenicity that correlated with prolonged pulmonary bacterial control in BCG-primed mice.