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cs.AI, q-bio.NC updates on arXiv.org
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Label-Guided Knowledge Distillation for 3D-CNNs in Action Recognition
arXiv:2609.13024v1 Announce Type: cross Abstract: As a key model compression technique, knowledge distillation aims to transfer knowledge from a high-capacity teacher model to a lightweight student model for enhancing the latter's performance. In this work, we reviewed the feature knowledge distillation for 3D-CNNs and observed that most feature distillation methods in video analysis are simple adaptations of those used in image analysis, often neglecting the differences of video features in th
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Omics in Hepatocellular
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Raspberry aqueous extract ameliorates MAFLD in mice by regulating gut microbiota and purine metabolism
Front Nutr. 2026 Apr 30;13:1818086. doi: 10.3389/fnut.2026.1818086. eCollection 2026.ABSTRACTINTRODUCTION: Metabolism-associated fatty liver disease (MAFLD) has emerged as a severe worldwide public health burden with insufficient available clinical therapeutic strategies, which underscores the urgent demand for safe, natural dietary interventions. Raspberry (Rubus idaeus L.), a typical food-medicine homologous fruit abundant in diverse bioactive components including anthocyanins, flavonoids and
Raspberry aqueous extract ameliorates MAFLD in mice by regulating gut microbiota and purine metabolism
Front Nutr. 2026 Apr 30;13:1818086. doi: 10.3389/fnut.2026.1818086. eCollection 2026.
ABSTRACT
INTRODUCTION: Metabolism-associated fatty liver disease (MAFLD) has emerged as a severe worldwide public health burden with insufficient available clinical therapeutic strategies, which underscores the urgent demand for safe, natural dietary interventions. Raspberry (Rubus idaeus L.), a typical food-medicine homologous fruit abundant in diverse bioactive components including anthocyanins, flavonoids and polysaccharides, possesses prominent nutritional and medicinal potential.
METHODS: In this study, raspberry aqueous extract (RE) was prepared to comprehensively investigate its ameliorative effects and underlying molecular mechanisms against MAFLD. MAFLD animal model was established in C57BL/6 mice via 12-week high-fat diet (HFD) feeding. From the 9th week, model mice were intragastrically administered with RE at doses of 1 g/kg/d and 2 g/kg/d for continuous intervention. Integrated multi-omics analyses including 16S rRNA microbial sequencing, serum/hepatic biochemical detection, histopathological examination, in vivo microbial colonization assay, and in vitro cellular and metabolomic experiments were performed to systematically clarify the regulatory mechanism.
RESULTS: RE treatment markedly improved the core pathological phenotypes of MAFLD mice, and significantly mitigated hepatic steatosis and hepatocellular injury. 16S rRNA sequencing demonstrated that RE remodeled the gut microbial dysbiosis, specifically elevating the abundance of beneficial genus Ileibacterium and suppressing pathogenic microbial taxa. Meanwhile, RE strengthened intestinal mucosal barrier integrity by upregulating tight junction protein expression, and activated hepatic purine metabolic reprogramming to boost the levels of critical metabolites including inosine and ADP. Spearman correlation analysis verified the significantly positive correlation between Ileibacterium abundance and hepatic inosine content, and both factors were closely correlated with the remission of MAFLD pathological indicators. In vivo colonization experiments further validated that Ileibacterium intervention alone remarkably alleviated hepatic lipid deposition and liver damage in MAFLD mice. In vitro strain metabolomics confirmed that Ileibacterium could directly biosynthesize and secrete inosine extracellularly. Furthermore, in vitro AML12 hepatocyte experiments revealed that 100 μM inosine remarkably relieved palmitic acid-induced lipotoxicity via reducing intracellular lipid overload, reactive oxygen species (ROS) accumulation and mitochondrial dysfunction, alongside modulating the expression of lipid metabolism, inflammatory and autophagy-related genes.
DISCUSSION: Collectively, our results elucidate that raspberry aqueous extract alleviates experimental MAFLD through the gut microbiota-purine metabolism-inosine regulatory axis, in which Ileibacterium and inosine act as the core synergistic mediators. This study provides solid preclinical experimental evidence for the development and application of raspberry as a promising functional food for the prevention and nutritional intervention of MAFLD.
PMID:42146077 | PMC:PMC13171365 | DOI:10.3389/fnut.2026.1818086
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cs.AI, q-bio.NC updates on arXiv.org
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Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
arXiv:2502.13388v3 Announce Type: replace Abstract: StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which is very suitable for artificial intelligence and reinforcement learning research. To address the problem of Large Language Model(LLM) learning in complex environments through self-reflection, we propose a Reflection of Episodes(ROE) framework based on expert experience and self-experience. This framework first obtains key information in the game through a ke
Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
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cs.AI, q-bio.NC updates on arXiv.org
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Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
arXiv:2502.13388v2 Announce Type: replace Abstract: StarCraft II is a complex and dynamic real-time strategy (RTS) game environment, which is very suitable for artificial intelligence and reinforcement learning research. To address the problem of Large Language Model(LLM) learning in complex environments through self-reflection, we propose a Reflection of Episodes(ROE) framework based on expert experience and self-experience. This framework first obtains key information in the game through a ke
Reflection of Episodes: Learning to Play Game from Expert and Self Experiences
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cs.AI, q-bio.NC updates on arXiv.org
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A Disentangled Representation Learning Framework for Low-altitude Network Coverage Prediction
arXiv:2507.14186v2 Announce Type: replace-cross Abstract: The expansion of the low-altitude economy has underscored the significance of Low-Altitude Network Coverage (LANC) prediction for designing aerial corridors. While accurate LANC forecasting hinges on the antenna beam patterns of Base Stations (BSs), these patterns are typically proprietary and not readily accessible. Operational parameters of BSs, which inherently contain beam information, offer an opportunity for data-driven low-altitud