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Received — 14 March 2026 ⏭

Nature - Issue - nature.com science feeds
Intestinal interoceptive dysfunction drives age-associated cognitive decline Timothy O. Cox · Ashwarya S. Devason · Alan de Araujo · Sydney Mason · Madhav Subramanian · Andrea F. M. Salvador · Hélène C. Descamps · Junwon Kim · Yixuan Zhu · Lev Litichevskiy · Sunhee Jung · Won-Suk Song · Adrián Cortés-Martín · Nathan T. Henderson · Kuei-Pin Huang · Thao Nguyen · Wisath Sae-Lee · Iboro C. Umana · Maria Sacta · Ryan J. Rahman · Stephen Wisser · J. Andrew D. Nelson · Ilona Golynker · Alana M. McSween · Eric F. Hohmann · Shaan Patel · Anna L. Bub · Clara Soekler · Niklas Blank · Kevt’her Hoxha · Lavinia Boccia · Andrea C. Wong · Klaas Bahnsen · Jihee Kim · Natalie Biderman · Dina Abbasian · Clarissa Shoffler · Christopher Petucci · Fiona E. McAllister · Amber L. Alhadeff · Marc V. Fuccillo · Colin Hill · Cholsoon Jang · J. Nicholas Betley · Guillaume de Lartigue · Virginia Y.-M. Lee · Maayan Levy · Christoph A. Thaiss
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10191-6Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.
11 March 2026 at 08:00

Intestinal interoceptive dysfunction drives age-associated cognitive decline

Nature - Issue - nature.com science feeds

By: Timothy O. Cox · Ashwarya S. Devason · Alan de Araujo · Sydney Mason · Madhav Subramanian · Andrea F. M. Salvador · Hélène C. Descamps · Junwon Kim · Yixuan Zhu · Lev Litichevskiy · Sunhee Jung · Won-Suk Song · Adrián Cortés-Martín · Nathan T. Henderson · Kuei-Pin Huang · Thao Nguyen · Wisath Sae-Lee · Iboro C. Umana · Maria Sacta · Ryan J. Rahman · Stephen Wisser · J. Andrew D. Nelson · Ilona Golynker · Alana M. McSween · Eric F. Hohmann · Shaan Patel · Anna L. Bub · Clara Soekler · Niklas Blank · Kevt’her Hoxha · Lavinia Boccia · Andrea C. Wong · Klaas Bahnsen · Jihee Kim · Natalie Biderman · Dina Abbasian · Clarissa Shoffler · Christopher Petucci · Fiona E. McAllister · Amber L. Alhadeff · Marc V. Fuccillo · Colin Hill · Cholsoon Jang · J. Nicholas Betley · Guillaume de Lartigue · Virginia Y.-M. Lee · Maayan Levy · Christoph A. Thaiss

11 March 2026 at 08:00

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10191-6

Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this gut–brain pathway restores memory in aged mice.