arXiv:2609.09905v1 Announce Type: cross Abstract: Preference alignment for flow and diffusion models now spans online reinforcement learning and offline preference optimization, but the relation between these methods remains unclear. In particular, existing forward-process alignment methods require fresh samples from the current model, while offline methods based on fixed preference pairs rely primarily on positive-only fine-tuning or DPO-style likelihood-ratio surrogates. We organize these approaches through a divergence-based framework and introduce FlowCPO, an offline forward-KL objective that uses both preferred and dispreferred samples without online rollouts. For linear interpolation, we show under explicit regularity conditions that the forward-KL objective is bounded by a contrastive flow matching loss, yielding a tractable surrogate on fixed data. We further show that this loss is nonnegative, whereas the signed regression loss of simplified FlowDPO can be unbounded below. In the in-domain setting, FlowCPO achieves higher mean GenEval and OCR scores than the evaluated baselines, reaching 0.84 and 0.87 versus 0.81 and 0.74 for FlowDPO at CFG 3.0. In the out-of-domain setting, the results are mixed, with the best GenEval result but lower reward scores than RFT on several metrics.

arXiv:2604.02369v2 Announce Type: replace-cross Abstract: Agent communication protocols are becoming critical infrastructure for large language model (LLM) systems that must use tools, coordinate with other agents, and operate across heterogeneous environments. This work presents a human-inspired perspective on this emerging landscape by organizing agent communication into three layers: communication, syntactic, and semantic. Under this framework, we systematically analyze 18 representative protocols and compare how they support reliable transport, structured interaction, and meaning-level coordination. Our analysis shows a clear imbalance in current protocol design. Most protocols provide increasingly mature support for transport, streaming, schema definition, and lifecycle management, but offer limited protocol-level mechanisms for clarification, context alignment, and verification. As a result, semantic responsibilities are often pushed into prompts, wrappers, or application-specific orchestration logic, creating hidden interoperability and maintenance costs. To make this gap actionable, we further identify major forms of technical debt in today's protocol ecosystem and distill practical guidance for selecting protocols under different deployment settings. We conclude by outlining a research agenda for interoperable, secure, and semantically robust agent ecosystems that move beyond message passing toward shared understanding.

Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation underlying erythema. Cryo-EM reveals a bipartite-acid pocket of OXGR1 that enables structure-guided development of A-1, a selective agonist that alleviates erythema in rosacea-like models.

arXiv:2504.21052v2 Announce Type: replace-cross Abstract: Multi-target backdoor attacks pose significant security threats to deep neural networks, as they can preset multiple target classes through a single backdoor injection. This allows attackers to control the model to misclassify poisoned samples with triggers into any desired target class during inference, exhibiting superior attack performance compared with conventional backdoor attacks. However, existing multi-target backdoor attacks fail to guarantee trigger specificity and stealthiness in black-box settings, resulting in two main issues. First, they are unable to simultaneously target all classes when only training data can be manipulated, limiting their effectiveness in realistic attack scenarios. Second, the triggers often lack visual imperceptibility, making poisoned samples easy to detect. To address these problems, we propose a Spatial-based Full-target Invisible Backdoor Attack, called SFIBA. It restricts triggers for different classes to specific local spatial regions and morphologies in the pixel space to ensure specificity, while employing a frequency-domain-based trigger injection method to guarantee stealthiness. Specifically, for injection of each trigger, we first apply fast fourier transform to obtain the amplitude spectrum of clean samples in local spatial regions. Then, we employ discrete wavelet transform to extract the features from the amplitude spectrum and use singular value decomposition to integrate the trigger. Subsequently, we selectively filter parts of the trigger in pixel space to implement trigger morphology constraints and adjust injection coefficients based on visual effects. We conduct experiments on multiple datasets and models. The results demonstrate that SFIBA can achieve excellent attack performance and stealthiness, while preserving the model's performance on benign samples, and can also bypass existing backdoor defenses.