Red blood cell-derived extracellular vesicles (RBCEVs) provide a scalable, non-viral platform for gene therapy. High-grade RBCEVs purified using tangential flow filtration can deliver sizable plasmids and mediate sustained in vivo expression of therapeutic proteins, including factor IX and Herceptin, highlighting their potential use for safe and efficient gene therapy.

arXiv:2602.22769v3 Announce Type: replace Abstract: Large Language Models (LLMs) are deployed as autonomous agents in increasingly complex applications, where enabling long-horizon memory is critical for achieving strong performance. However, a significant gap exists between applications and evaluation standards for agent memory: existing benchmarks primarily focus on dialogue-centric settings. In reality, agent memory consists of a continuous stream of agent-environment interactions that are primarily composed of machine-generated representations. To bridge this gap, we introduce AMA-Bench (Agent Memory with Any Length), a benchmark designed to evaluate long-horizon memory for LLMs in real agentic applications. It features two key components: (1) a set of real-world agentic trajectories across representative agentic applications, paired with expert-curated QA, and (2) a set of synthetic agentic trajectories of arbitrary horizons paired with rule-based QA. Our comprehensive study shows that existing memory systems underperform on AMA-Bench primarily because they lack causality and objective information, and are constrained by the lossy nature of similarity-based retrieval employed by many memory systems. To address these limitations, we propose AMA-Agent, an effective memory system featuring a causality graph and tool-augmented retrieval. Our results demonstrate that AMA-Agent achieves 57.22% average accuracy on AMA-Bench, surpassing the strongest baselines by 11.16%. Resources are available at our project website: https://ama-bench.github.io/

arXiv:2604.23853v2 Announce Type: replace Abstract: Skill-distillation pipelines learn reusable rules from LLM agent trajectories, but they lack a key signal: how much each step costs. Without per-step cost, a pipeline cannot distinguish adding a missing step to fix a bug from removing an expensive step that never affected the outcome. We use the cost-attribution gap to ask whether the rule types inside a distilled skill transfer the same way to new tasks. ClawTrace records cost-attributed agent traces and compiles each session into a TraceCard; CostCraft reads TraceCards and writes three kinds of skill patches: preserve, prune, and repair. We find a pattern aggregate metrics hide. On 30 held-out SpreadsheetBench tasks across two seeds, removing prune patches roughly tripled the quality-regression count without lowering median cost. Across the full 84-task SkillsBench transfer, CostCraft saves no aggregate cost. All three quality regressions trace to the preserve lane, and both quality wins trace to the prune lane: prune patches act as quality guardrails while preserve patches drive regressions. We argue that reusable agent skills should be evaluated at the rule-type level, not as monolithic instruction packages. To support this, we release ClawTrace, the TraceCard schema, and the full set of typed skills.

arXiv:2602.22769v2 Announce Type: replace Abstract: Large Language Models (LLMs) are deployed as autonomous agents in increasingly complex applications, where enabling long-horizon memory is critical for achieving strong performance. However, a significant gap exists between practical applications and current evaluation standards for agent memory: existing benchmarks primarily focus on dialogue-centric, human-agent interactions. In reality, agent memory consists of a continuous stream of agent-environment interactions that are primarily composed of machine-generated representations. To bridge this gap, we introduce AMA-Bench (Agent Memory with Any length), which evaluates long-horizon memory for LLMs in real agentic applications. It features two key components: (1) a set of real-world agentic trajectories across representative agentic applications, paired with expert-curated QA, and (2) a set of synthetic agentic trajectories that scale to arbitrary horizons, paired with rule-based QA. Our comprehensive study shows that existing memory systems underperform on AMA-Bench primarily because they lack causality and objective information and are constrained by the lossy nature of similarity-based retrieval employed by many memory systems. To address these limitations, we propose AMA-Agent, an effective memory system featuring a causality graph and tool-augmented retrieval. Our results demonstrate that AMA-Agent achieves 57.22% average accuracy on AMA-Bench, surpassing the strongest memory system baselines by 11.16%.