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Received — 15 September 2026 ⏭

Nature Biomedical Engineering
Dense RNA motif modifications enable robust in vivo prime editing and enhance efficiencies of diverse editing systems Xinlin Lei · Didi Chen · Kun Zhang · Xiyu Liu · Qiubing Chen · Yizhou Zhang · Ruijin Ji · Jicheng Zhu · Qingyi Zhang · Ying Zhang · Hao Yin
Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.
11 September 2026 at 08:00

Dense RNA motif modifications enable robust in vivo prime editing and enhance efficiencies of diverse editing systems

By: Xinlin Lei · Didi Chen · Kun Zhang · Xiyu Liu · Qiubing Chen · Yizhou Zhang · Ruijin Ji · Jicheng Zhu · Qingyi Zhang · Ying Zhang · Hao Yin

11 September 2026 at 08:00

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4

Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.