arXiv:2601.22984v2 Announce Type: replace Abstract: Diagnosing failure patterns in Deep Research Agents (DRAs) remains a critical challenge. Existing benchmarks predominantly rely on end-to-end evaluation, obscuring intermediate hallucinations that accumulate throughout the research trajectory. To bridge this gap, we propose a shift from outcome-based to processaware evaluation by auditing hallucinations in the full plan-search-summarize trajectory. We introduce the PING Taxonomy, which categorizes DRA hallucinations into four complementary types: Propagation, Intent, Noiseinduced, and Grounding. We further instantiate this taxonomy into a fine-grained evaluation framework that decomposes trajectories into atomic actions, claims, and sub-queries for rigorous verification. Leveraging this framework to isolate 100 distinctively hallucinationprone tasks including adversarial scenarios, we curate DeepHalluBench. Experiments on six representative DRAs show that, on our hallucination-prone stress-test set, all evaluated systems still exhibit non-negligible reliability gaps. Furthermore, our diagnostic analysis traces these failures to systemic deficits, especially hallucination propagation and cognitive biases, providing actionable insights for future architectural optimization. Code and data are available in https://github.com/yuhao-zhan/DeepHalluBench.

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10244-w

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

arXiv:2602.14010v1 Announce Type: cross Abstract: Pathology foundation models (PFMs) have enabled robust generalization in computational pathology through large-scale datasets and expansive architectures, but their substantial computational cost, particularly for gigapixel whole slide images, limits clinical accessibility and scalability. Here, we present LitePath, a deployment-friendly foundational framework designed to mitigate model over-parameterization and patch level redundancy. LitePath integrates LiteFM, a compact model distilled from three large PFMs (Virchow2, H-Optimus-1 and UNI2) using 190 million patches, and the Adaptive Patch Selector (APS), a lightweight component for task-specific patch selection. The framework reduces model parameters by 28x and lowers FLOPs by 403.5x relative to Virchow2, enabling deployment on low-power edge hardware such as the NVIDIA Jetson Orin Nano Super. On this device, LitePath processes 208 slides per hour, 104.5x faster than Virchow2, and consumes 0.36 kWh per 3,000 slides, 171x lower than Virchow2 on an RTX3090 GPU. We validated accuracy using 37 cohorts across four organs and 26 tasks (26 internal, 9 external, and 2 prospective), comprising 15,672 slides from 9,808 patients disjoint from the pretraining data. LitePath ranks second among 19 evaluated models and outperforms larger models including H-Optimus-1, mSTAR, UNI2 and GPFM, while retaining 99.71% of the AUC of Virchow2 on average. To quantify the balance between accuracy and efficiency, we propose the Deployability Score (D-Score), defined as the weighted geometric mean of normalized AUC and normalized FLOP, where LitePath achieves the highest value, surpassing Virchow2 by 10.64%. These results demonstrate that LitePath enables rapid, cost-effective and energy-efficient pathology image analysis on accessible hardware while maintaining accuracy comparable to state-of-the-art PFMs and reducing the carbon footprint of AI deployment.