Nature Biomedical Engineering, Published online: 23 September 2026; doi:10.1038/s41551-026-01793-6

Contrary to expectations that unsaturation accelerates release, unsaturated phospholipid liposomes showed 3-fold higher loading and markedly reduced initial and sustained release due to multilamellar–multivesicular structure.

Cell Death Discovery, Published online: 16 September 2026; doi:10.1038/s41420-026-03349-8

ESAM reduces sensitivity to anti-HER2 therapy in HER2-positive breast cancer by activating the mTOR pathway

Cell Death Discovery, Published online: 08 September 2026; doi:10.1038/s41420-026-03339-w

Lipotoxicity-induced ER-mitochondrial hypercoupling activates the mtDNA-cGAS-STING-NF-κB axis to drive follicular arrest in metabolically compromised PCOS

arXiv:2605.24973v1 Announce Type: cross Abstract: VLM-based OCR models have become the de facto choice for document parsing, as they can accurately extract page-level elements (e.g., paragraphs within individual pages) together with their bounding boxes and textual content. However, downstream applications such as RAG require coherent document-level information, whereas these models often break cross-page continuity and fail to recover disrupted structures, such as paragraphs and tables truncated by page boundaries. Such relationships are not confined to a single page; instead, they require joint analysis of titles, paragraphs, tables, and images spanning multiple pages. A natural solution is therefore to reuse existing OCR outputs and reconstruct document-level logical structures through post-processing. To this end, we propose MinerU-Popo, a lightweight and universal framework for POst-Processing OCR outputs, which converts page-level results from diverse parsers into coherent document-level structures. MinerU-Popo decomposes the problem into four focused subtasks: text truncation recovery, table truncation recovery, title hierarchy reconstruction, and image-text association. To address these effectively, we build a task-oriented data engine with task-specific input filtering, and use the generated data (30K) to fine-tune a lightweight post-processing model (Qwen3-VL-4B). To support long documents, we introduce dynamic chunking with overlap-based synchronization, which aligns chunk-level outputs from the fine-tuned model and preserves global consistency. Finally, we assemble the aligned outputs into a tree-structured document representation, further enriched with node chunking and summaries for downstream retrieval and analysis. Empirical results show MinerU-Popo improves title-hierarchy TEDS by at least 20% across all five tested OCR models, improves RAG accuracy and reduces per-query latency.

arXiv:2604.03647v1 Announce Type: cross Abstract: In the unsupervised self-evolution of Multimodal Large Language Models, the quality of feedback signals during post-training is pivotal for stable and effective learning. However, existing self-evolution methods predominantly rely on majority voting to select the most frequent output as the pseudo-golden answer, which may stem from the model's intrinsic biases rather than guaranteeing the objective correctness of the reasoning paths. To counteract the degradation, we propose \textbf{C}ontinuous \textbf{S}oftened \textbf{R}etracing re\textbf{S}ampling (\textbf{CSRS}) in MLLM self-evolution. Specifically, we introduce a Retracing Re-inference Mechanism (\textbf{RRM}) that the model re-inferences from anchor points to expand the exploration of long-tail reasoning paths. Simultaneously, we propose Softened Frequency Reward (\textbf{SFR}), which replaces binary rewards with continuous signals, calibrating reward based on the answers' frequency across sampled reasoning sets. Furthermore, incorporated with Visual Semantic Perturbation (\textbf{VSP}), CSRS ensures the model prioritizes mathematical logic over visual superficiality. Experimental results demonstrate that CSRS significantly enhances the reasoning performance of Qwen2.5-VL-7B on benchmarks such as MathVision. We achieve state-of-the-art (SOTA) results in unsupervised self-evolution on geometric tasks. Our code is avaible at https://github.com/yyy195/CSRS.

arXiv:2603.21289v2 Announce Type: replace-cross Abstract: Recent progress in multimodal large language models has led to strong performance on reasoning tasks, but these improvements largely rely on high-quality annotated data or teacher-model distillation, both of which are costly and difficult to scale. To address this, we propose an unsupervised self-evolution training framework for multimodal reasoning that achieves stable performance improvements without using human-annotated answers or external reward models. For each input, we sample multiple reasoning trajectories and jointly model their within group structure. We use the Actor's self-consistency signal as a training prior, and introduce a bounded Judge based modulation to continuously reweight trajectories of different quality. We further model the modulated scores as a group level distribution and convert absolute scores into relative advantages within each group, enabling more robust policy updates. Trained with Group Relative Policy Optimization (GRPO) on unlabeled data, our method consistently improves reasoning performance and generalization on five mathematical reasoning benchmarks, offering a scalable path toward self-evolving multimodal models. The code are available at https://github.com/OPPO-Mente-Lab/LLM-Self-Judge.

arXiv:2510.27623v3 Announce Type: replace Abstract: Recent advances in Vision-Language Models (VLMs) have propelled embodied agents by enabling direct perception, reasoning, and planning task-oriented actions from visual inputs. However, such vision-driven embodied agents open a new attack surface: visual backdoor attacks, where the agent behaves normally until a visual trigger appears in the scene, then persistently executes an attacker-specified multi-step policy. We introduce BEAT, the first framework to inject such visual backdoors into VLM-based embodied agents using objects in the environments as triggers. Unlike textual triggers, object triggers exhibit wide variation across viewpoints and lighting, making them difficult to implant reliably. BEAT addresses this challenge by (1) constructing a training set that spans diverse scenes, tasks, and trigger placements to expose agents to trigger variability, and (2) introducing a two-stage training scheme that first applies supervised fine-tuning (SFT) and then our novel Contrastive Trigger Learning (CTL). CTL formulates trigger discrimination as preference learning between trigger-present and trigger-free inputs, explicitly sharpening the decision boundaries to ensure precise backdoor activation. Across various embodied agent benchmarks and VLMs, BEAT achieves attack success rates up to 80%, while maintaining strong benign task performance, and generalizes reliably to out-of-distribution trigger placements. Notably, compared to naive SFT, CTL boosts backdoor activation accuracy up to 39% under limited backdoor data. These findings expose a critical yet unexplored security risk in VLM-based embodied agents, underscoring the need for robust defenses before real-world deployment.

arXiv:2204.07520v4 Announce Type: replace-cross Abstract: Multi-robot decision-making is the process where multiple robots coordinate actions. In this paper, we aim for efficient and effective multi-robot decision-making despite the robots' limited on-board resources and the often resource-demanding complexity of their tasks. We introduce the first algorithm enabling the robots to choose with which few other robots to coordinate and provably balance the trade-off of centralized vs. decentralized coordination. Particularly, centralization favors globally near-optimal decision-making but at the cost of increased on-board resource requirements; whereas, decentralization favors minimal resource requirements but at a global suboptimality cost. All robots can thus afford our algorithm, irrespective of their resources. We are motivated by the future of autonomy that involves multiple robots coordinating actions to complete resource-demanding tasks, such as target tracking, area coverage, and monitoring. To provide closed-form guarantees, we focus on maximization problems involving monotone and 2nd-order submodular functions. To capture the cost of decentralization, we introduce the notion of Centralization Of Information among non-Neighbors (COIN). We validate our algorithm in simulated scenarios of image covering.

arXiv:2602.14699v1 Announce Type: cross Abstract: This paper envisions a quantum database (Qute) that treats quantum computation as a first-class execution option. Unlike prior simulation-based methods that either run quantum algorithms on classical machines or adapt existing databases for quantum simulation, Qute instead (i) compiles an extended form of SQL into gate-efficient quantum circuits, (ii) employs a hybrid optimizer to dynamically select between quantum and classical execution plans, (iii) introduces selective quantum indexing, and (iv) designs fidelity-preserving storage to mitigate current qubit constraints. We also present a three-stage evolution roadmap toward quantum-native database. Finally, by deploying Qute on a real quantum processor (origin_wukong), we show that it outperforms a classical baseline at scale, and we release an open-source prototype at https://github.com/weAIDB/Qute.