❌

Normal view

JudgmentBench: Comparing Rubric and Preference Evaluation for Quality Assessment

arXiv:2605.25240v1 Announce Type: cross Abstract: Two methodologies dominate current practices of benchmarking: rubric-based scoring evaluates items against predefined criteria, whereas comparative judgment elicits pairwise preferences between outputs. Although both methodologies are widely used, the choice between them is rarely justified. We release JudgmentBench, a benchmark of 30 real-world legal tasks, paired with 1,539 rubric scores and 1,530 pairwise preference judgments collected from practicing attorneys--including at major U.S. law firms--with substantial experience. The annotations constitute the first publicly available dataset in a high-expertise domain in which both supervision signals are elicited from the same experts on the same items. Using LLM-generated outputs at three constructed quality levels, we provide an initial empirical comparison: comparative judgments recover the intended quality ordering substantially better than rubrics (mean Spearman's rank correlation of 0.908 vs. 0.150, estimated difference = 0.758 [0.494, 1.021]) while requiring less than half the annotation time. The patterns hold for human annotators and LLM autograders. Beyond this initial comparison, the paired structure of the dataset supports a broader research agenda on how expert judgment should be elicited, aggregated, and used as supervision in domains without verifiable ground truth.

The Yin and Yang of tertiary lymphoid structures in primary liver cancer

29 March 2026 at 18:00

Cancer Lett. 2026 Mar 27;648:218461. doi: 10.1016/j.canlet.2026.218461. Online ahead of print.

ABSTRACT

Tertiary lymphoid structures (TLSs) have emerged as key regulators of anti-tumor immunity and biomarkers for immunotherapy response in liver cancer, including hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and combined hepatocellular-cholangiocarcinoma (cHCC-iCCA). Advances in single-cell and spatial multi-omics technologies have revealed unprecedented complexity in TLSs, challenging the traditional binary classification of TLSs as simply "good" or "bad". Their functional diversity appears to be shaped by spatiotemporal context, cellular composition, and maturation status. This review provides a comprehensive synthesis of TLSs in liver cancer, employing the Yin-Yang paradigm to navigate their functional dualism and prognostic contradictions through a detailed analysis of their identification, classification, and spatiotemporal interactions within the TME. Mechanistically, we elucidate how TLS functions are orchestrated by complex interactions between tumor cells, immune cell subsets, stromal components, and systemic factors. Within this framework, key metabolic drivers, notably ATP citrate lyase (ACLY), and signaling axes such as cGAS-STING/mTOR have emerged as pivotal regulators of TLS ontogeny. In addition, we evaluate current preclinical animal models and therapeutic strategies for clinical TLS induction. Furthermore, we have discussed the key unanswered questions in the field, including the three-dimensional architecture of TLSs and the mechanisms by which they establish durable immunological memory independent of the primary tumor. Clinically, TLSs exhibit great promise as prognostic and predictive biomarkers, particularly in the context of immune checkpoint blockade and locoregional therapies. Finally, we identify challenges in standardization, mechanistic understanding, and translational applications, providing directions for future research to harness TLSs for improving liver cancer outcomes.

PMID:41905709 | DOI:10.1016/j.canlet.2026.218461

Rapid concerted switching of the neural code in the inferotemporal cortex

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10267-3

Face cells in the macaque inferotemporal cortex are initially able to detect faces and then rapidly switch to a face-specific neural code to discriminate between different face identities.
❌