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Received β€” 13 April 2026 ⏭

Effect of the Maxing Huoqiao granule on nonsevere community-acquired pneumonia: A multicenter, double-blind, placebo-controlled randomized trial

βœ‡(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
By: Qingming Ke Β· Caiping Zhao Β· Shengda Luo Β· Yuntao Liu Β· Ye Ye Β· Xingdong Lin Β· Jing Zeng Β· Xinghua Liu Β· Yang Liao Β· Hongtao Li Β· Shu Chen Β· Hong Ren Β· Liang Liu Β· Hudan Pan
12 April 2026 at 18:00

Pharmacol Res. 2026 Apr 9:108186. doi: 10.1016/j.phrs.2026.108186. Online ahead of print.

ABSTRACT

Community-acquired pneumonia (CAP) remains a major global public health challenge with substantial morbidity and mortality. Although preclinical studies suggest that Maxing Huoqiao (MXHQ) granule may have therapeutic potential for pneumonia, high-quality clinical evidence is still limited. We conducted a multicenter, double-blind, randomized, placebo-controlled trial at two tertiary hospitals in China to evaluate the clinical efficacy of MXHQ as adjunctive therapy and to explore its potential mechanisms in adults with nonsevere CAP receiving standard moxifloxacin treatment. A total of 96 patients were enrolled and randomized (1:1:1) to receive standard-dose MXHQ, low-dose MXHQ, or placebo in addition to moxifloxacin for 7 days, with a 14-day follow-up. The primary endpoint was clinical cure, defined as composite recovery of major respiratory symptoms, lung rales, and fever; secondary endpoints included symptom relief, radiographic improvement, and safety. Compared with placebo, standard-dose MXHQ was associated with a higher day-14 clinical cure rate (30.78% vs. 68.97%; RR = 0.45, 95% CI = 0.24-0.83; P < 0.01). Furthermore, the standard-dose intervention was correlated with a shorter time to relief and recovery of cough and sputum (P < 0.05), as well as improvements in symptom scores (P < 0.05) and promoting lesion absorption on chest CT (P < 0.05). Low-dose MXHQ showed no significant clinical benefit, whereas safety profiles were comparable across all groups. Transcriptomic analyses of peripheral blood mononuclear cells, complemented by a Streptococcus pneumonia animal model, indicated that the clinical benefits of MXHQ are linked to the modulation of inflammation and innate immunity. These omics and in vivo observations suggest a potential mechanism underlying the protective effects of MXHQ against inflammatory injury and promotion of tissue repair, involving the regulation of anti-inflammatory mediators and tissue repair-related factors. (Chictr.org.cn, ID Number: ChiCTR2400082095).

PMID:41966499 | DOI:10.1016/j.phrs.2026.108186

Received β€” 8 April 2026 ⏭

Making Prompts First-Class Citizens for Adaptive LLM Pipelines

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Ugur Cetintemel Β· Shu Chen Β· Alexander W. Lee Β· Deepti Raghavan Β· Duo Lu Β· Andrew Crotty
7 April 2026 at 12:00
arXiv:2508.05012v2 Announce Type: replace-cross Abstract: Modern LLM pipelines increasingly resemble complex data-centric applications: they retrieve data, correct errors, call external tools, and coordinate interactions between agents. Yet, the central element controlling this entire process -- the prompt -- remains a brittle, opaque string that is entirely disconnected from the surrounding program logic. This disconnect fundamentally limits opportunities for reuse, optimization, and runtime adaptivity. In this paper, we describe our vision and an initial design of SPEAR (Structured Prompt Execution and Adaptive Refinement), a new approach to prompt management that treats prompts as first-class citizens in the execution model. Specifically, SPEAR enables: (1) structured prompt management, with prompts organized into versioned views to support introspection and reasoning about provenance; (2) adaptive prompt refinement, whereby prompts can evolve dynamically during execution based on runtime feedback; and (3) policy-driven control, a mechanism for the specification of automatic prompt refinement logic as when-then rules. By tackling the problem of runtime prompt refinement, SPEAR plays a complementary role in the vast ecosystem of existing prompt optimization frameworks and semantic query processing engines. We describe a number of related optimization opportunities unlocked by the SPEAR model, and our preliminary results demonstrate the strong potential of this approach.
Received β€” 17 March 2026 ⏭

RooflineBench: A Benchmarking Framework for On-Device LLMs via Roofline Analysis

βœ‡cs.AI, q-bio.NC updates on arXiv.org
By: Zhen Bi Β· Xueshu Chen Β· Luoyang Sun Β· Yuhang Yao Β· Qing Shen Β· Jungang Lou Β· Cheng Deng
16 March 2026 at 12:00
arXiv:2602.11506v3 Announce Type: replace-cross Abstract: The transition toward localized intelligence through Small Language Models (SLMs) has intensified the need for rigorous performance characterization on resource-constrained edge hardware. However, objectively measuring the theoretical performance ceilings of diverse architectures across heterogeneous platforms remains a formidable challenge. In this work, we propose a systematic framework based on the Roofline model that unifies architectural primitives and hardware constraints through the lens of operational intensity (OI). By defining an inference-potential region, we introduce the Relative Inference Potential as a novel metric to compare efficiency differences between Large Language Models (LLMs) on the same hardware substrate. Extensive empirical analysis across diverse compute tiers reveals that variations in performance and OI are significantly influenced by sequence length. We further identify a critical regression in OI as model depth increases. Additionally, our findings highlight an efficiency trap induced by hardware heterogeneity and demonstrate how structural refinements, such as Multi-head Latent Attention (M LA), can effectively unlock latent inference potential across various hardware substrates. These insights provide actionable directions for hardware-software co-design to align neural structures with physical constraints in on-device intelligence. The released code is available in the Appendix C.
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