Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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DisDop: Distillation with Domain Priors for Open-Vocabulary Aerial Object Detection
arXiv:2605.24639v1 Announce Type: cross Abstract: With the widespread application of drones in recent years, object detection of aerial images has attracted increasing attention, especially open-vocabulary aerial detection which is not restricted to predefined categories. Due to the scarcity of drone's viewpoint images and their significant differences from natural images, it is difficult to achieve satisfying results by directly applying vanilla open-vocabulary detection methods designed for n
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Omics In Lung
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Dunhuang Daxiefei Decoction ameliorates acute lung injury via the HIF-1alpha/glycolysis/H3K18la axis
J Ethnopharmacol. 2026 Mar 26;365:121591. doi: 10.1016/j.jep.2026.121591. Online ahead of print.ABSTRACTETHNOPHARMACOLOGICAL RELEVANCE: Acute lung injury (ALI) lacks effective therapies. HIF-1α-driven glycolysis can promote histone lactylation and sustain pro-inflammatory (M1) macrophage responses. Daxiefei Decoction (DXFD), a classic traditional Chinese medicine formula, is used for pulmonary inflammatory diseases, but its immunometabolic mechanism remains unclear.AIM OF THE STUDY: To evaluate
Dunhuang Daxiefei Decoction ameliorates acute lung injury via the HIF-1alpha/glycolysis/H3K18la axis
J Ethnopharmacol. 2026 Mar 26;365:121591. doi: 10.1016/j.jep.2026.121591. Online ahead of print.
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE: Acute lung injury (ALI) lacks effective therapies. HIF-1α-driven glycolysis can promote histone lactylation and sustain pro-inflammatory (M1) macrophage responses. Daxiefei Decoction (DXFD), a classic traditional Chinese medicine formula, is used for pulmonary inflammatory diseases, but its immunometabolic mechanism remains unclear.
AIM OF THE STUDY: To evaluate the protective efficacy of DXFD against lipopolysaccharide (LPS)-induced ALI and to determine whether it acts through the HIF-1α/glycolysis/histone H3K18 lactylation (H3K18la) axis to regulate macrophage polarization.
MATERIALS & METHODS: DXFD constituents were characterized by UPLC-LTQ-Orbitrap-MS/MS, followed by network pharmacology, molecular docking, and molecular dynamics (MD) simulations. Lung transcriptomics and metabolomics were performed in ALI mice. Efficacy and mechanisms were assessed in LPS-challenged mice and RAW264.7 macrophages using histopathology, ELISA, qRT-PCR, Western blotting, and immunofluorescence. HIF-1α overexpression was used for validation.
RESULTS: DXFD dose-dependently alleviated lung injury and reduced pro-inflammatory cytokines in vivo, and suppressed M1 polarization in vivo and in LPS-stimulated macrophages. Multi-omics indicated activation of HIF-1α-associated inflammatory and glycolytic programs in ALI, which were normalized by DXFD. DXFD decreased glycolytic enzyme expression and reduced histone H3K18 lactylation (H3K18la); these effects were partially reversed by HIF-1α overexpression. Molecular docking and dynamics suggested stable binding of baicalin to HIF-1α.
CONCLUSIONS: DXFD mitigates ALI by dampening HIF-1α-dependent glycolysis and H3K18la, thereby restraining M1-driven inflammatory amplification.
PMID:41903585 | DOI:10.1016/j.jep.2026.121591
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cs.AI, q-bio.NC updates on arXiv.org
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Social-JEPA: Emergent Geometric Isomorphism
arXiv:2603.02263v1 Announce Type: cross Abstract: World models compress rich sensory streams into compact latent codes that anticipate future observations. We let separate agents acquire such models from distinct viewpoints of the same environment without any parameter sharing or coordination. After training, their internal representations exhibit a striking emergent property: the two latent spaces are related by an approximate linear isometry, enabling transparent translation between them. Thi
Social-JEPA: Emergent Geometric Isomorphism
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cs.AI, q-bio.NC updates on arXiv.org
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MolReasoner: Toward Effective and Interpretable Reasoning for Molecular LLMs
arXiv:2508.02066v2 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have shown impressive performance across various domains, but their ability to perform molecular reasoning remains underexplored. Existing methods mostly rely on general-purpose prompting, which lacks domain-specific molecular semantics, or fine-tuning, which faces challenges in interpretability and reasoning depth, often leading to structural and textual hallucinations. To address these issues, we introduce