arXiv:2609.12394v1 Announce Type: new Abstract: Mobile GUI agents are shifting from multi-module frameworks to native models trained end-to-end, yet industrial deployment faces three persistent gaps. Sandbox training produces a distribution mismatch with production environments; expensive real-device failures remain underutilized; and fixed benchmarks saturate, losing the power to guide iteration. We present BlueLM-GUI, a 35B-A3B mobile GUI agent built as a real-device-centric flywheel that closes these gaps through three principles. Every Sample Matters: a dual-track pipeline with Heterogeneous Triple-System Consensus evaluation and an Error Correction \& Derivation Module salvages every trajectory into usable supervision. Every Rollout Is Real: a three-stage recipe---continual pre-training, supervised fine-tuning, and agentic reinforcement learning on hundreds of real phones---grounds every rollout in real production environments, so the capability the model learns transfers directly to deployment. Every Query Evolves: a quota-driven benchmark methodology with three orthogonal axes enables precise attribution and allows the benchmark to be systematically upgraded as the model improves. BlueLM-GUI achieves 87.4 on MobileGUI-VBench, surpassing the best closed-source model by 5.1 points, and 84.9 on AndroidWorld, the best result among open-source models and competitive with closed-source models. These results demonstrate that grounding model training and iterative improvement in both real devices and the three Every principles yields strong, robust, and transferable mobile GUI capability.

arXiv:2608.27875v2 Announce Type: replace Abstract: Quantization has been widely adopted in LLM training and inference to reduce cost and improve efficiency. However, low-bit quantization of the \emph{attention} module often introduces large errors at very low bit-widths, causing performance degradation. Existing methods mainly rely on smoothing techniques to handle outliers, while we propose a hybrid quantization design to better balance accuracy and efficiency. Specifically, we propose \textbf{HyQuant}, an efficient hybrid quantization framework for LLM attention. HyQuant quantizes most attention states into low-bit formats while retaining a small set of vertical-line tokens and local-window states in high precision. These accuracy-critical regions are selected using lightweight vertical-line-aware attention-pattern signals, reducing quantization error with limited overhead. In the Prefill stage, HyQuant uses a hybrid-precision quantized attention operator that preserves vertical-line tokens and a local sliding window in full precision while quantizing the remaining context. In the Decode stage, HyQuant applies the same principle to KV-cache compression and fuses KV dequantization with attention computation to improve memory and hardware efficiency. Across diverse tasks, models, and datasets, HyQuant maintains nearly lossless accuracy with an extremely simple design, demonstrating the efficiency and practical feasibility of hybrid quantization for LLM attention. Code is available at: https://github.com/jerrysfls/HyQuant .

Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04621-1

The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health.

arXiv:2511.02860v2 Announce Type: replace-cross Abstract: The distribution and interactions of cellular organelles play a critical role in mediating cellular physiology and pathology. Large-scale electron microscopy enables visualization of organelle distribution and interactions at the tissue level with nanometer resolution, but robust and efficient computational analysis tools are lacking. Here, we present a deep learning tool for universal large-scale 2D/3D electron microscopy analysis, DeepOrganelle. This new tool enables high-throughput, cell-resolved spatiotemporal mapping and digitization of organelle distribution and interactions. When applied to spermatogenesis across 12 stages and 22 differentiation status of the germ cells, DeepOrganelle uncovered previously unrecognized, stage-dependent dynamics of mitochondria-endoplasmic reticulum contact sites within one subphase of prophase I during meiosis. It also revealed coordinated organelle redistribution in Sertoli cells towards the blood-testis barrier, digitizing the remodeling dynamics of the tissue. This study demonstrates that DeepOrganelle provides a powerful framework that captures subcellular dynamics at the whole-tissue level.