Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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PsychAgent: An Experience-Driven Lifelong Learning Agent for Self-Evolving Psychological Counselor
arXiv:2604.00931v2 Announce Type: replace Abstract: Existing methods for AI psychological counselors predominantly rely on supervised fine-tuning using static dialogue datasets. However, this contrasts with human experts, who continuously refine their proficiency through clinical practice and accumulated experience. To bridge this gap, we propose an Experience-Driven Lifelong Learning Agent (\texttt{PsychAgent}) for psychological counseling. First, we establish a Memory-Augmented Planning Engin
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cs.AI, q-bio.NC updates on arXiv.org
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NI-Tex: Non-isometric Image-based Garment Texture Generation
arXiv:2511.18765v2 Announce Type: replace-cross Abstract: Existing industrial 3D garment meshes already cover most real-world clothing geometries, yet their texture diversity remains limited. To acquire more realistic textures, generative methods are often used to extract Physically-based Rendering (PBR) textures and materials from large collections of wild images and project them back onto garment meshes. However, most image-conditioned texture generation approaches require strict topological
NI-Tex: Non-isometric Image-based Garment Texture Generation
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(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
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Latilactobacillus curvatus IM01 Alleviates Allergic Airway Inflammation Through Microbial and Metabolic Crosstalk Along the Gut-Lung Axis
Nutrients. 2026 Mar 4;18(5):834. doi: 10.3390/nu18050834.ABSTRACTBackground: Gut microbiota dysbiosis is critically implicated in the pathogenesis of allergic airway inflammation (AAI) via the gut-lung axis. While Latilactobacillus curvatus is a promising probiotic candidate, its specific immunomodulatory mechanisms in respiratory diseases remain poorly understood. Objective: In this study, we investigated the protective effects and underlying mechanisms of L. curvatus IM01 in an ovalbumin (OVA)
Latilactobacillus curvatus IM01 Alleviates Allergic Airway Inflammation Through Microbial and Metabolic Crosstalk Along the Gut-Lung Axis
Nutrients. 2026 Mar 4;18(5):834. doi: 10.3390/nu18050834.
ABSTRACT
Background: Gut microbiota dysbiosis is critically implicated in the pathogenesis of allergic airway inflammation (AAI) via the gut-lung axis. While Latilactobacillus curvatus is a promising probiotic candidate, its specific immunomodulatory mechanisms in respiratory diseases remain poorly understood. Objective: In this study, we investigated the protective effects and underlying mechanisms of L. curvatus IM01 in an ovalbumin (OVA)-induced murine AAI model using an integrated multi-omics approach. Results: Our results demonstrated that oral administration of L. curvatus IM01 significantly attenuated airway inflammation, suppressed Th2-type immune responses, and reduced serum IgE levels. Crucially, our multi-omics integration revealed a coherent gut-lung axis narrative driven by microbial and metabolic crosstalk. Specifically, 16S rRNA sequencing indicated that L. curvatus IM01 was closely linked to structural shifts in the gut microbial community, notably characterized by an enrichment trend for beneficial genera such as Odoribacter and Lactobacillus. This microbial restructuring was closely associated with a modulated cecal metabolic profile, as untargeted metabolomics exhibited a clear trend toward the restoration of key systemically active immunoregulatory metabolites, including indolelactic acid (ILA) and choline, which have been previously linked to the alleviation of AAI symptoms. Further linking this metabolic shift to respiratory immune tolerance, lung transcriptomic analysis showed that the treatment is strongly associated with the promotion of the differentiation of CD4+ T cells into Foxp3+ regulatory T cells (Tregs). Conclusions: Collectively, these findings suggest a novel potential pathway by which L. curvatus IM01 modulates the gut-lung axis through coordinated microbial and metabolic interventions, highlighting its potential as a therapeutic functional food ingredient for AAI.
PMID:41830004 | PMC:PMC12987261 | DOI:10.3390/nu18050834
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Omics In Lung
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Latilactobacillus curvatus IM01 Alleviates Allergic Airway Inflammation Through Microbial and Metabolic Crosstalk Along the Gut-Lung Axis
Nutrients. 2026 Mar 4;18(5):834. doi: 10.3390/nu18050834.ABSTRACTBackground: Gut microbiota dysbiosis is critically implicated in the pathogenesis of allergic airway inflammation (AAI) via the gut-lung axis. While Latilactobacillus curvatus is a promising probiotic candidate, its specific immunomodulatory mechanisms in respiratory diseases remain poorly understood. Objective: In this study, we investigated the protective effects and underlying mechanisms of L. curvatus IM01 in an ovalbumin (OVA)
Latilactobacillus curvatus IM01 Alleviates Allergic Airway Inflammation Through Microbial and Metabolic Crosstalk Along the Gut-Lung Axis
Nutrients. 2026 Mar 4;18(5):834. doi: 10.3390/nu18050834.
ABSTRACT
Background: Gut microbiota dysbiosis is critically implicated in the pathogenesis of allergic airway inflammation (AAI) via the gut-lung axis. While Latilactobacillus curvatus is a promising probiotic candidate, its specific immunomodulatory mechanisms in respiratory diseases remain poorly understood. Objective: In this study, we investigated the protective effects and underlying mechanisms of L. curvatus IM01 in an ovalbumin (OVA)-induced murine AAI model using an integrated multi-omics approach. Results: Our results demonstrated that oral administration of L. curvatus IM01 significantly attenuated airway inflammation, suppressed Th2-type immune responses, and reduced serum IgE levels. Crucially, our multi-omics integration revealed a coherent gut-lung axis narrative driven by microbial and metabolic crosstalk. Specifically, 16S rRNA sequencing indicated that L. curvatus IM01 was closely linked to structural shifts in the gut microbial community, notably characterized by an enrichment trend for beneficial genera such as Odoribacter and Lactobacillus. This microbial restructuring was closely associated with a modulated cecal metabolic profile, as untargeted metabolomics exhibited a clear trend toward the restoration of key systemically active immunoregulatory metabolites, including indolelactic acid (ILA) and choline, which have been previously linked to the alleviation of AAI symptoms. Further linking this metabolic shift to respiratory immune tolerance, lung transcriptomic analysis showed that the treatment is strongly associated with the promotion of the differentiation of CD4+ T cells into Foxp3+ regulatory T cells (Tregs). Conclusions: Collectively, these findings suggest a novel potential pathway by which L. curvatus IM01 modulates the gut-lung axis through coordinated microbial and metabolic interventions, highlighting its potential as a therapeutic functional food ingredient for AAI.
PMID:41830004 | PMC:PMC12987261 | DOI:10.3390/nu18050834
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cs.AI, q-bio.NC updates on arXiv.org
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SynPlanResearch-R1: Encouraging Tool Exploration for Deep Research with Synthetic Plans
arXiv:2603.07853v1 Announce Type: new Abstract: Research Agents enable models to gather information from the web using tools to answer user queries, requiring them to dynamically interleave internal reasoning with tool use. While such capabilities can in principle be learned via reinforcement learning with verifiable rewards (RLVR), we observe that agents often exhibit poor exploration behaviors, including premature termination and biased tool usage. As a result, RLVR alone yields limited impro
SynPlanResearch-R1: Encouraging Tool Exploration for Deep Research with Synthetic Plans
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cs.AI, q-bio.NC updates on arXiv.org
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Discriminative Perception via Anchored Description for Reasoning Segmentation
arXiv:2603.04002v1 Announce Type: cross Abstract: Reasoning segmentation increasingly employs reinforcement learning to generate explanatory reasoning chains that guide Multimodal Large Language Models. While these geometric rewards are primarily confined to guiding the final localization, they are incapable of discriminating whether the reasoning process remains anchored on the referred region or strays into irrelevant context. Lacking this discriminative guidance, the model's reasoning often
Discriminative Perception via Anchored Description for Reasoning Segmentation
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cs.AI, q-bio.NC updates on arXiv.org
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3D Wavelet-Based Structural Priors for Controlled Diffusion in Whole-Body Low-Dose PET Denoising
arXiv:2601.07093v4 Announce Type: replace-cross Abstract: Low-dose Positron Emission Tomography (PET) imaging reduces patient radiation exposure but suffers from increased noise that degrades image quality and diagnostic reliability. Although diffusion models have demonstrated strong denoising capability, their stochastic nature makes it challenging to enforce anatomically consistent structures, particularly in low signal-to-noise regimes and volumetric whole-body imaging. We propose Wavelet-Co
3D Wavelet-Based Structural Priors for Controlled Diffusion in Whole-Body Low-Dose PET Denoising
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cs.AI, q-bio.NC updates on arXiv.org
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NI-Tex: Non-isometric Image-based Garment Texture Generation
arXiv:2511.18765v1 Announce Type: cross Abstract: Existing industrial 3D garment meshes already cover most real-world clothing geometries, yet their texture diversity remains limited. To acquire more realistic textures, generative methods are often used to extract Physically-based Rendering (PBR) textures and materials from large collections of wild images and project them back onto garment meshes. However, most image-conditioned texture generation approaches require strict topological consiste
NI-Tex: Non-isometric Image-based Garment Texture Generation
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cs.AI, q-bio.NC updates on arXiv.org
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OmniVideo-R1: Reinforcing Audio-visual Reasoning with Query Intention and Modality Attention
arXiv:2602.05847v2 Announce Type: replace Abstract: While humans perceive the world through diverse modalities that operate synergistically to support a holistic understanding of their surroundings, existing omnivideo models still face substantial challenges on audio-visual understanding tasks. In this paper, we propose OmniVideo-R1, a novel reinforced framework that improves mixed-modality reasoning. OmniVideo-R1 empowers models to "think with omnimodal cues" by two key strategies: (1) query-i