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cs.AI, q-bio.NC updates on arXiv.org
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FEAT: A Linear-Complexity Foundation Model for Extremely Large Structured Data
arXiv:2603.16513v4 Announce Type: replace-cross Abstract: Structured data is widely used in domains such as healthcare, finance, and scientific data management. Recent studies on structured data foundation models (SFMs) aim to support data analysis and mining tasks over such data, but still face scalability and generalization challenges when applied to real-world enterprise databases. First, many SFMs rely on full self-attention, which introduces an O(N^2) computational bottleneck and limits th
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cs.AI, q-bio.NC updates on arXiv.org
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Reliable AI Needs to Externalize Implicit Knowledge: A Human-AI Collaboration Perspective
arXiv:2605.02010v2 Announce Type: replace Abstract: This position paper argues that reliable AI requires infrastructure for human validation of implicit knowledge. AI learns from both explicit knowledge (papers, documentation, structured databases) and implicit knowledge (reasoning patterns, debugging processes, intermediate steps). Implicit knowledge remains unexternalized because documentation cost exceeds perceived value -- yet AI learns from it indiscriminately, acquiring both beneficial pa
Reliable AI Needs to Externalize Implicit Knowledge: A Human-AI Collaboration Perspective
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cs.AI, q-bio.NC updates on arXiv.org
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Reward-free Alignment for Conflicting Objectives
arXiv:2602.02495v3 Announce Type: replace-cross Abstract: Direct alignment methods are increasingly used to align large language models (LLMs) with human preferences. However, many real-world alignment problems involve multiple conflicting objectives, where naive aggregation of preferences can lead to unstable training and poor trade-offs. In particular, weighted loss methods may fail to identify update directions that simultaneously improve all objectives, and existing multi-objective approach
Reward-free Alignment for Conflicting Objectives
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cs.AI, q-bio.NC updates on arXiv.org
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How AI Aggregation Affects Knowledge
arXiv:2604.04906v1 Announce Type: cross Abstract: Artificial intelligence (AI) changes social learning when aggregated outputs become training data for future predictions. To study this, we extend the DeGroot model by introducing an AI aggregator that trains on population beliefs and feeds synthesized signals back to agents. We define the learning gap as the deviation of long-run beliefs from the efficient benchmark, allowing us to capture how AI aggregation affects learning. Our main result id
How AI Aggregation Affects Knowledge
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cs.AI, q-bio.NC updates on arXiv.org
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C-TRAIL: A Commonsense World Framework for Trajectory Planning in Autonomous Driving
arXiv:2603.29908v1 Announce Type: new Abstract: Trajectory planning for autonomous driving increasingly leverages large language models (LLMs) for commonsense reasoning, yet LLM outputs are inherently unreliable, posing risks in safety-critical applications. We propose C-TRAIL, a framework built on a Commonsense World that couples LLM-derived commonsense with a trust mechanism to guide trajectory planning. C-TRAIL operates through a closed-loop Recall, Plan, and Update cycle: the Recall module
C-TRAIL: A Commonsense World Framework for Trajectory Planning in Autonomous Driving
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Pulmonary nodule
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Profiling of the mycobiome and metabolome: a comparative study of benign pulmonary nodules and lung adenocarcinoma
Front Cell Infect Microbiol. 2026 Feb 23;16:1732958. doi: 10.3389/fcimb.2026.1732958. eCollection 2026.ABSTRACTINTRODUCTION: Lung adenocarcinoma (LUAD), the most common subtype of non-small cell lung cancer, is a form of malignant pulmonary nodule that requires clinical differentiation from benign pulmonary nodules (BPN). The mechanisms underlying the development of LUAD are complex, and effective non-invasive methods for differentiating BPN from LUAD are lacking. This study aimed not only to di
Profiling of the mycobiome and metabolome: a comparative study of benign pulmonary nodules and lung adenocarcinoma
Front Cell Infect Microbiol. 2026 Feb 23;16:1732958. doi: 10.3389/fcimb.2026.1732958. eCollection 2026.
ABSTRACT
INTRODUCTION: Lung adenocarcinoma (LUAD), the most common subtype of non-small cell lung cancer, is a form of malignant pulmonary nodule that requires clinical differentiation from benign pulmonary nodules (BPN). The mechanisms underlying the development of LUAD are complex, and effective non-invasive methods for differentiating BPN from LUAD are lacking. This study aimed not only to distinguish BPN from LUAD using gut fungi and serum metabolites, but also to establish an integrated network of gut fungi-metabolite-cytokine interactions.
METHODS: Fecal and serum samples from individuals with BPN and patients with LUAD were subjected to internal transcribed spacer sequencing, ultra-performance liquid chromatography-tandem mass spectrometry, and multiplex Luminex assays to quantify gut fungi, metabolites, and cytokines, respectively.
RESULTS: A significant difference in gut fungal communities was observed between the BPN and LUAD groups. Multiple genera and species were more abundant in LUAD than in BPN. Docosapentaenoic acid n-6 (DPAn-6), indole-3-propionic acid (IPA), and interferon-Ξ³-induced protein 10 (IP-10) were significantly elevated in the LUAD group. The integrated model established using a combination of gut fungi and metabolites demonstrated excellent performance in distinguishing BPN from LUAD. A network of interactions was established among differentially abundant gut fungi, serum metabolites, and cytokines.
CONCLUSION: Our study identifies a novel panel of fungal and metabolite biomarkers for differentiating between BPN and LUAD, and constructs a multi-omics network that provides new insights into investigating the mechanistic role of gut mycobiota dysbiosis in LUAD.
PMID:41809995 | PMC:PMC12968269 | DOI:10.3389/fcimb.2026.1732958