Nature Biotechnology, Published online: 31 August 2026; doi:10.1038/s41587-026-03302-1

Recyclable LYTACs induce macropinocytosis to degrade proteins.

arXiv:2605.15777v2 Announce Type: replace Abstract: Computer-Using Agents (CUAs) are rapidly extending large language models (LLMs) beyond text-based reasoning toward action execution in more complex environments, such as web browsers and graphical user interfaces (GUIs). However, existing web and GUI agent benchmarks often rely on simplified settings, isolated tasks, or short-horizon interactions, making it difficult to assess capabilities of agents in realistic professional workflows. Software-as-a-Service (SaaS) environments are a natural choice for CUA evaluation, as they host a large share of modern digital work and naturally involve dynamic system states, cross-application coordination, domain-specific knowledge, and long-horizon dependencies. To this end, we introduce SaaS-Bench, a benchmark built on 23 deployable SaaS systems across six professional domains, containing 106 tasks grounded in realistic work scenarios. These tasks require long-horizon execution, cover both text-only and multimodal settings, and are evaluated with weighted verification checkpoints that measure strict task completion and partial progress. Experiments show that representative LLM-based agents struggle on SaaS-Bench, with even the strongest model completing fewer than 4% of tasks end-to-end, exposing limitations in planning, state tracking, cross-application context maintenance, and error recovery. Code are available at https://github.com/UniPat-AI/SaaS-Bench for reproduction.

arXiv:2602.14602v1 Announce Type: cross Abstract: The opioid epidemic continues to ravage communities worldwide, straining healthcare systems, disrupting families, and demanding urgent computational solutions. To combat this lethal opioid crisis, graph learning methods have emerged as a promising paradigm for modeling complex drug-related phenomena. However, a significant gap remains: there is no comprehensive benchmark for systematically evaluating these methods across real-world opioid crisis scenarios. To bridge this gap, we introduce OPBench, the first comprehensive opioid benchmark comprising five datasets across three critical application domains: opioid overdose detection from healthcare claims, illicit drug trafficking detection from digital platforms, and drug misuse prediction from dietary patterns. Specifically, OPBench incorporates diverse graph structures, including heterogeneous graphs and hypergraphs, to preserve the rich and complex relational information among drug-related data. To address data scarcity, we collaborate with domain experts and authoritative institutions to curate and annotate datasets while adhering to privacy and ethical guidelines. Furthermore, we establish a unified evaluation framework with standardized protocols, predefined data splits, and reproducible baselines to facilitate fair and systematic comparison among graph learning methods. Through extensive experiments, we analyze the strengths and limitations of existing graph learning methods, thereby providing actionable insights for future research in combating the opioid crisis. Our source code and datasets are available at https://github.com/Tianyi-Billy-Ma/OPBench.

arXiv:2602.14919v1 Announce Type: cross Abstract: Hypergraph Neural Networks (HyGNNs) have demonstrated remarkable success in modeling higher-order relationships among entities. However, their performance often degrades on heterophilic hypergraphs, where nodes connected by the same hyperedge tend to have dissimilar semantic representations or belong to different classes. While several HyGNNs, including our prior work BHyGNN, have been proposed to address heterophily, their reliance on labeled data significantly limits their applicability in real-world scenarios where annotations are scarce or costly. To overcome this limitation, we introduce BHyGNN+, a self-supervised learning framework that extends BHyGNN for representation learning on heterophilic hypergraphs without requiring ground-truth labels. The core idea of BHyGNN+ is hypergraph duality, a structural transformation where the roles of nodes and hyperedges are interchanged. By contrasting augmented views of a hypergraph against its dual using cosine similarity, our framework captures essential structural patterns in a fully unsupervised manner. Notably, this duality-based formulation eliminates the need for negative samples, a common requirement in existing hypergraph contrastive learning methods that is often difficult to satisfy in practice. Extensive experiments on eleven benchmark datasets demonstrate that BHyGNN+ consistently outperforms state-of-the-art supervised and self-supervised baselines on both heterophilic and homophilic hypergraphs. Our results validate the effectiveness of leveraging hypergraph duality for self-supervised learning and establish a new paradigm for representation learning on challenging, unlabeled hypergraphs.