This study identifies AAV2.7m8-Myo15 as a safe and efficient vector for transducing cochlear outer hair cells in adult mice via posterior semicircular canal injection. These insights overcome age-related transduction barriers and suggest potential gene therapy strategies for sensorineural hearing loss.

arXiv:2604.03980v1 Announce Type: cross Abstract: Parameter-efficient prompt learning has become the de facto standard for adapting Vision-Language Models (VLMs) to downstream tasks. Existing approaches predominantly focus on aligning text prompts with first-order visual features (i.e., spatial feature maps). While effective for fine-grained semantic discrimination, we argue that relying solely on first-order information is insufficient for robust adaptation, as these spatially entangled features are highly susceptible to domain shifts and local noise. In this work, we propose \textbf{Gram-Anchored Prompt Learning (GAPL)} for Vision-Language Models via Second-Order Statistics, a framework that synergizes local semantic alignment with global structural consistency. Methodologically, we introduce an additional second-order statistical stream via \textbf{Gram matrices} that augments the standard first-order spatial interaction. By anchoring prompts to these second-order priors, our approach enables language representations to dynamically adapt to statistical distribution shifts across diverse domains. Extensive experiments indicate the effectiveness of the second-order features, and show compelling performances of GAPL on various benchmarks.