Normal view
-
Molecular Therapy
-
Precise hepatic base editing of ASGR1 enables robust and durable LDLR-independent lipid lowering in vivo
Yang and colleagues demonstrate that lipid nanoparticle-mediated precise hepatic ASGR1 base editing safely produces robust and durable lipid lowering in an LDLR-deficient mouse model of familial hypercholesterolemia. Their work further benchmarks the lipid-lowering effects of ASGR1 and ANGPTL3 editing and supports combined ASGR1/ANGPTL3 targeting for enhanced cholesterol lowering.
-
(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
-
Multi-Omics Identification of Biomarkers for High-Altitude Pulmonary Hypertension
J Cardiovasc Dev Dis. 2026 Apr 30;13(5):195. doi: 10.3390/jcdd13050195.ABSTRACT(1) Aim: The incidence of high-altitude pulmonary hypertension (HAPH) has risen in recent years and is expected to continue increasing; however, its diagnosis remains challenging. In this study, we employed proteomics and metabolomics to identify the proteins and metabolic biomarkers that contribute to the development of HAPH. (2) Methods: We applied integrated proteomics and metabolomics to match blood samples from 4
Multi-Omics Identification of Biomarkers for High-Altitude Pulmonary Hypertension
J Cardiovasc Dev Dis. 2026 Apr 30;13(5):195. doi: 10.3390/jcdd13050195.
ABSTRACT
(1) Aim: The incidence of high-altitude pulmonary hypertension (HAPH) has risen in recent years and is expected to continue increasing; however, its diagnosis remains challenging. In this study, we employed proteomics and metabolomics to identify the proteins and metabolic biomarkers that contribute to the development of HAPH. (2) Methods: We applied integrated proteomics and metabolomics to match blood samples from 40 HAPH patients and 40 healthy controls in Yunnan's high-altitude regions to characterize molecular profiles, identify biomarkers, and develop a predictive model. (3) Results: Proteomic analysis identified four proteins (A2IPH7, K1C14, PSME2, SERPINE2) commonly dysregulated in HAPH patients from two high-altitude regions. SERPINE2 was notably downregulated and showed a negative correlation with clinical severity, which was further validated in HAPH rat lung tissues and supported by UK Biobank data for idiopathic PAH. Concurrent metabolomics uncovered 11 shared metabolites, largely acyl fatty acids, enriched in pathways such as unsaturated fatty acid synthesis. Integration of these multi-omics data enabled the development of a robust predictive model. (4) Conclusion: Our study identified key protein and metabolic biomarkers involved in HAPH development, which were validated in animal models. Based on these findings, a predictive model was developed, highlighting SERPINE2 and 11 metabolites as promising targets for the prediction and prevention of HAPH.
PMID:42188081 | DOI:10.3390/jcdd13050195
-
Omics In Lung
-
Multi-Omics Identification of Biomarkers for High-Altitude Pulmonary Hypertension
J Cardiovasc Dev Dis. 2026 Apr 30;13(5):195. doi: 10.3390/jcdd13050195.ABSTRACT(1) Aim: The incidence of high-altitude pulmonary hypertension (HAPH) has risen in recent years and is expected to continue increasing; however, its diagnosis remains challenging. In this study, we employed proteomics and metabolomics to identify the proteins and metabolic biomarkers that contribute to the development of HAPH. (2) Methods: We applied integrated proteomics and metabolomics to match blood samples from 4
Multi-Omics Identification of Biomarkers for High-Altitude Pulmonary Hypertension
J Cardiovasc Dev Dis. 2026 Apr 30;13(5):195. doi: 10.3390/jcdd13050195.
ABSTRACT
(1) Aim: The incidence of high-altitude pulmonary hypertension (HAPH) has risen in recent years and is expected to continue increasing; however, its diagnosis remains challenging. In this study, we employed proteomics and metabolomics to identify the proteins and metabolic biomarkers that contribute to the development of HAPH. (2) Methods: We applied integrated proteomics and metabolomics to match blood samples from 40 HAPH patients and 40 healthy controls in Yunnan's high-altitude regions to characterize molecular profiles, identify biomarkers, and develop a predictive model. (3) Results: Proteomic analysis identified four proteins (A2IPH7, K1C14, PSME2, SERPINE2) commonly dysregulated in HAPH patients from two high-altitude regions. SERPINE2 was notably downregulated and showed a negative correlation with clinical severity, which was further validated in HAPH rat lung tissues and supported by UK Biobank data for idiopathic PAH. Concurrent metabolomics uncovered 11 shared metabolites, largely acyl fatty acids, enriched in pathways such as unsaturated fatty acid synthesis. Integration of these multi-omics data enabled the development of a robust predictive model. (4) Conclusion: Our study identified key protein and metabolic biomarkers involved in HAPH development, which were validated in animal models. Based on these findings, a predictive model was developed, highlighting SERPINE2 and 11 metabolites as promising targets for the prediction and prevention of HAPH.
PMID:42188081 | DOI:10.3390/jcdd13050195
-
npj Digital Medicine
-
Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification
npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02602-9Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification
Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification
npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02602-9
Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification-
cs.AI, q-bio.NC updates on arXiv.org
-
Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation
arXiv:2604.02368v3 Announce Type: replace Abstract: As Large Language Models (LLMs) exhibit plateauing performance on conventional benchmarks, a pivotal challenge persists: evaluating their proficiency in complex, open-ended tasks characterizing genuine expert-level cognition. Existing frameworks suffer from narrow domain coverage, reliance on generalist tasks, or self-evaluation biases. To bridge this gap, we present XpertBench, a high-fidelity benchmark engineered to assess LLMs across authen
Xpertbench: Expert Level Tasks with Rubrics-Based Evaluation
-
cs.AI, q-bio.NC updates on arXiv.org
-
OccSim: Multi-kilometer Simulation with Long-horizon Occupancy World Models
arXiv:2603.28887v1 Announce Type: cross Abstract: Data-driven autonomous driving simulation has long been constrained by its heavy reliance on pre-recorded driving logs or spatial priors, such as HD maps. This fundamental dependency severely limits scalability, restricting open-ended generation capabilities to the finite scale of existing collected datasets. To break this bottleneck, we present OccSim, the first occupancy world model-driven 3D simulator. OccSim obviates the requirement for cont
OccSim: Multi-kilometer Simulation with Long-horizon Occupancy World Models
-
cs.AI, q-bio.NC updates on arXiv.org
-
Heracles: Bridging Precise Tracking and Generative Synthesis for General Humanoid Control
arXiv:2603.27756v2 Announce Type: replace-cross Abstract: Achieving general-purpose humanoid control requires a delicate balance between the precise execution of commanded motions and the flexible, anthropomorphic adaptability needed to recover from unpredictable environmental perturbations. Current general controllers predominantly formulate motion control as a rigid reference-tracking problem. While effective in nominal conditions, these trackers often exhibit brittle, non-anthropomorphic fai
Heracles: Bridging Precise Tracking and Generative Synthesis for General Humanoid Control
-
cs.AI, q-bio.NC updates on arXiv.org
-
Rethinking the Role of Entropy in Optimizing Tool-Use Behaviors for Large Language Model Agents
arXiv:2602.02050v3 Announce Type: replace Abstract: Tool-using agents based on Large Language Models (LLMs) excel in tasks such as mathematical reasoning and multi-hop question answering. However, in long trajectories, agents often trigger excessive and low-quality tool calls, increasing latency and degrading inference performance, making managing tool-use behavior challenging. In this work, we conduct entropy-based pilot experiments and observe a strong positive correlation between entropy red
Rethinking the Role of Entropy in Optimizing Tool-Use Behaviors for Large Language Model Agents
-
cs.AI, q-bio.NC updates on arXiv.org
-
Behavioral Consistency Validation for LLM Agents: An Analysis of Trading-Style Switching through Stock-Market Simulation
arXiv:2602.07023v2 Announce Type: replace-cross Abstract: Recent works have increasingly applied Large Language Models (LLMs) as agents in financial stock market simulations to test if micro-level behaviors aggregate into macro-level phenomena. However, a crucial question arises: Do LLM agents' behaviors align with real market participants? This alignment is key to the validity of simulation results. To explore this, we select a financial stock market scenario to test behavioral consistency. In