Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia.

Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03000-6Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression