Normal view
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cs.AI, q-bio.NC updates on arXiv.org
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DeGRe: Dense-supervised Generative Reranking for Recommendation
arXiv:2605.25749v1 Announce Type: cross Abstract: In multi-stage recommender systems, reranking optimizes overall utility by capturing intra-list contextual dependencies, yet its central challenge lies in exploring optimal sequences within an exponentially large permutation space. Recent studies have shifted towards end-to-end generative frameworks, which typically leverage list-wise rewards or preference alignment to guide generator training. However, these methods still face two critical issu
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Omics In Lung
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ANP32E drives lung adenocarcinoma progression via GSK3beta-mediated glycolytic reprogramming
Cell Death Dis. 2026 Apr 14. doi: 10.1038/s41419-026-08712-2. Online ahead of print.ABSTRACTLung adenocarcinoma (LUAD), a leading cause of cancer mortality, involves incompletely understood epigenetic-metabolic crosstalk. We identified ANP32E as a key regulator through multi-omics (TCGA, scRNA-seq) and clinical analyses, finding its overexpression correlates with poor prognosis. Functionally, ANP32E knockdown suppressed proliferation, migration, and glycolysis in LUAD cells (A549/H1975) and atte
ANP32E drives lung adenocarcinoma progression via GSK3beta-mediated glycolytic reprogramming
Cell Death Dis. 2026 Apr 14. doi: 10.1038/s41419-026-08712-2. Online ahead of print.
ABSTRACT
Lung adenocarcinoma (LUAD), a leading cause of cancer mortality, involves incompletely understood epigenetic-metabolic crosstalk. We identified ANP32E as a key regulator through multi-omics (TCGA, scRNA-seq) and clinical analyses, finding its overexpression correlates with poor prognosis. Functionally, ANP32E knockdown suppressed proliferation, migration, and glycolysis in LUAD cells (A549/H1975) and attenuated xenograft growth, while overexpression promoted tumorigenesis. Mechanistically, ANP32E transcriptionally upregulates histone demethylase KDM3B, reducing repressive H3K9me2 marks at the EGFR promoter to enhance EGFR transcription. This activates PI3K/AKT signaling, inducing inhibitory GSK3β phosphorylation. Combined with ANP32E-mediated GSK3β suppression, this dual inactivation liberates oncogenic glycolysis. Crucially, KDM3B silencing or EGFR inhibition (Cetuximab) abrogated ANP32E-driven phenotypes. High-throughput screening identified Penta-O-galloyl-β-D-glucose (PGG) as an ANP32E-targeting compound, with molecular dynamics confirming binding. PGG dose-dependently inhibited the ANP32E/KDM3B/EGFR axis in vitro and suppressed tumor growth in vivo. Thus, ANP32E drives LUAD progression via KDM3B/EGFR-mediated GSK3β inactivation, representing a prognostic biomarker and therapeutic target validated by PGG.
PMID:41980942 | DOI:10.1038/s41419-026-08712-2
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cs.AI, q-bio.NC updates on arXiv.org
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HISA: Efficient Hierarchical Indexing for Fine-Grained Sparse Attention
arXiv:2603.28458v3 Announce Type: replace-cross Abstract: Token-level sparse attention mechanisms, exemplified by DeepSeek Sparse Attention (DSA), achieve fine-grained key selection by scoring every historical key for each query through a lightweight indexer, then computing attention only on the selected subset. While the downstream sparse attention itself scales favorably, the indexer must still scan the entire prefix for every query, introducing an per-layer bottleneck that grows prohibitivel
HISA: Efficient Hierarchical Indexing for Fine-Grained Sparse Attention
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cs.AI, q-bio.NC updates on arXiv.org
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Evaluating VLMs' Spatial Reasoning Over Robot Motion: A Step Towards Robot Planning with Motion Preferences
arXiv:2603.13100v1 Announce Type: cross Abstract: Understanding user instructions and object spatial relations in surrounding environments is crucial for intelligent robot systems to assist humans in various tasks. The natural language and spatial reasoning capabilities of Vision-Language Models (VLMs) have the potential to enhance the generalization of robot planners on new tasks, objects, and motion specifications. While foundation models have been applied to task planning, it is still unclea
Evaluating VLMs' Spatial Reasoning Over Robot Motion: A Step Towards Robot Planning with Motion Preferences
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cs.AI, q-bio.NC updates on arXiv.org
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MalURLBench: A Benchmark Evaluating Agents' Vulnerabilities When Processing Web URLs
arXiv:2601.18113v3 Announce Type: replace-cross Abstract: LLM-based web agents have become increasingly popular for their utility in daily life and work. However, they exhibit critical vulnerabilities when processing malicious URLs: accepting a disguised malicious URL enables subsequent access to unsafe webpages, which can cause severe damage to service providers and users. Despite this risk, no benchmark currently targets this emerging threat. To address this gap, we propose MalURLBench, the f
MalURLBench: A Benchmark Evaluating Agents' Vulnerabilities When Processing Web URLs
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cs.AI, q-bio.NC updates on arXiv.org
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GeoSeg: Training-Free Reasoning-Driven Segmentation in Remote Sensing Imagery
arXiv:2603.03983v1 Announce Type: cross Abstract: Recent advances in MLLMs are reframing segmentation from fixed-category prediction to instruction-grounded localization. While reasoning based segmentation has progressed rapidly in natural scenes, remote sensing lacks a generalizable solution due to the prohibitive cost of reasoning-oriented data and domain-specific challenges like overhead viewpoints. We present GeoSeg, a zero-shot, training-free framework that bypasses the supervision bottlen