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cs.AI, q-bio.NC updates on arXiv.org
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Certified Training with Branch-and-Bound for Lyapunov-stable Neural Control
arXiv:2411.18235v3 Announce Type: replace-cross Abstract: We study the problem of learning verifiably Lyapunov-stable neural controllers that provably satisfy the Lyapunov asymptotic stability condition within a region-of-attraction (ROA). Unlike previous works that adopted counterexample-guided training without considering the computation of verification in training, we introduce Certified Training with Branch-and-Bound (CT-BaB), a new certified training framework that optimizes certified boun
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Omics In Lung
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Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.ABSTRACTPulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and exp
Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis
Nat Commun. 2026 Mar 20;17(1):2655. doi: 10.1038/s41467-026-70193-w.
ABSTRACT
Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive. Using integrated single-cell multi-omics profiling of human pulmonary fibrosis specimens and experimental fibrosis models induced by bleomycin or silica, we identify mechanosensitive Piezo1 upregulation in Endothelial cells as a hallmark of fibrotic progression. Endothelial-specific Piezo1 knockout significantly attenuates Bleomycin-induced fibrotic remodeling in male mice, establishing its pathogenic necessity. Mechanistically, PIEZO1 activation promotes pulmonary fibrosis development via CAPN2-mediated STAT3 phosphorylation, which may regulate the secretion of the pro-fibrotic molecule interleukin-33. These findings suggest that the endothelial PIEZO1-CAPN2-STAT3-IL33 axis is a potential therapeutic target for PF intervention.
PMID:41862476 | PMC:PMC13004862 | DOI:10.1038/s41467-026-70193-w
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cs.AI, q-bio.NC updates on arXiv.org
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Talking with Verifiers: Automatic Specification Generation for Neural Network Verification
arXiv:2603.02235v1 Announce Type: cross Abstract: Neural network verification tools currently support only a narrow class of specifications, typically expressed as low-level constraints over raw inputs and outputs. This limitation significantly hinders their adoption and practical applicability across diverse application domains where correctness requirements are naturally expressed at a higher semantic level. This challenge is rooted in the inherent nature of deep neural networks, which learn