Normal view
-
cs.AI, q-bio.NC updates on arXiv.org
-
K-Bench: A Benchmark for LLM Unlearning in Agentic Deployments
arXiv:2609.12808v1 Announce Type: new Abstract: Unlearning benchmarks such as TOFU and MUSE certify forgetting by reading the model's final answer, where a model that refuses to answer already counts as having forgotten. We show that this model-level certificate does not transfer once the model is deployed as an agent. We introduce K-Bench, a benchmark that scores LLM unlearning under agentic deployment. K-Bench inspects all six channels a ReAct agent exposes, including its chain-of-thought (Co
-
Omics in Hepatocellular
-
Integrated single-cell multi-omics characterization reveals lipid-associated macrophage-mediated immunosuppression in neoadjuvant immunotherapy of hepatocellular carcinoma
Nat Commun. 2026 Jul 31;17(1):9381. doi: 10.1038/s41467-026-75949-y.ABSTRACTHepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rate. Although immune checkpoint inhibitors (ICIs) improved survival outcomes for HCC patients, limited objective response rate highlights the urgency of investigating determinants of immunotherapy. Here, we explore HCC resistance mechanisms following neoadjuvant αPD-1 immunotherapy by constructing a comprehensive multi-modal single-cell transcr
Integrated single-cell multi-omics characterization reveals lipid-associated macrophage-mediated immunosuppression in neoadjuvant immunotherapy of hepatocellular carcinoma
Nat Commun. 2026 Jul 31;17(1):9381. doi: 10.1038/s41467-026-75949-y.
ABSTRACT
Hepatocellular carcinoma (HCC) is a cancer with high incidence and mortality rate. Although immune checkpoint inhibitors (ICIs) improved survival outcomes for HCC patients, limited objective response rate highlights the urgency of investigating determinants of immunotherapy. Here, we explore HCC resistance mechanisms following neoadjuvant αPD-1 immunotherapy by constructing a comprehensive multi-modal single-cell transcriptomic atlas consisting of 14 HCC patients treated with αPD-1 from our cohort (ClinicalTrials.gov ID: NCT06571396) and 60 external HCC cases with heterogeneous treatment backgrounds. Supervised by clinical outcomes of our cohort, we identify positive and negative regulators of immunotherapy within the tumor immune microenvironment (TIME), especially lipid-associated macrophages (LAM) with increased lipid metabolic state in non-responders and characterized by C1QA, FABP1, and APOA1 expression. We further show the presence, exogenous inducements and immunosuppressive functions of LAM, along with regulation strategies of its lipid-associated condition, including lycopene and chiglitazar. Furthermore, we construct interaction networks of immune regulators across responders and non-responders, showing distinct ligand-receptor landscapes with intervention targets. We reveal the TIME components including immunosuppressive LAMs that influence immunotherapy outcomes, thus providing evidence and insights for exploring immune landscape and therapeutic strategies for HCC immunotherapy. ClinicalTrials.gov ID: NCT06571396.
PMID:42680737 | PMC:PMC13534469 | DOI:10.1038/s41467-026-75949-y
-
cs.AI, q-bio.NC updates on arXiv.org
-
Safety in Embodied AI: A Survey of Risks, Attacks, and Defenses
arXiv:2605.02900v2 Announce Type: replace-cross Abstract: Embodied Artificial Intelligence (Embodied AI) integrates perception, cognition, planning, and interaction into agents that operate in open-world, safety-critical environments. As these systems gain autonomy and enter domains such as transportation, healthcare, and industrial or assistive robotics, ensuring their safety becomes both technically challenging and socially indispensable. Unlike digital AI systems, embodied agents must act un
Safety in Embodied AI: A Survey of Risks, Attacks, and Defenses
-
cs.AI, q-bio.NC updates on arXiv.org
-
Circuit Mechanisms for Spatial Relation Generation in Diffusion Transformers
arXiv:2601.06338v2 Announce Type: replace Abstract: Diffusion Transformers (DiTs) have greatly advanced text-to-image generation, but models still struggle to generate the correct spatial relations between objects as specified in the text prompt. In this study, we adopt a mechanistic interpretability approach to investigate how a DiT can generate correct spatial relations between objects. We train, from scratch, DiTs of different sizes with different text encoders to learn to generate images co
Circuit Mechanisms for Spatial Relation Generation in Diffusion Transformers
-
cs.AI, q-bio.NC updates on arXiv.org
-
MRI-to-CT synthesis using drifting models
arXiv:2603.28498v2 Announce Type: replace-cross Abstract: Accurate MRI-to-CT synthesis could enable MR-only pelvic workflows by providing CT-like images with bone details while avoiding additional ionizing radiation. In this work, we investigate recently proposed drifting models for synthesizing pelvis CT images from MRI and benchmark them against convolutional neural networks (UNet, VAE), a generative adversarial network (WGAN-GP), a physics-inspired probabilistic model (PPFM), and diffusion-b
MRI-to-CT synthesis using drifting models
-
npj Digital Medicine
-
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3
Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma-
Cell Death Discovery nature.com science feeds
-
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03000-6Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression
Cell Death Discovery, Published online: 10 March 2026; doi:10.1038/s41420-026-03000-6
Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression-
cs.AI, q-bio.NC updates on arXiv.org
-
MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMs
arXiv:2602.12705v3 Announce Type: replace-cross Abstract: We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous
MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMs
-
cs.AI, q-bio.NC updates on arXiv.org
-
MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMs
arXiv:2602.12705v2 Announce Type: replace-cross Abstract: We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous