arXiv:2609.09754v1 Announce Type: new Abstract: As large language models are increasingly deployed as tool-augmented legal agents, they introduce agentic hallucinations where tool-call and reasoning errors cascade into fabricated holdings and miscited authority. However, existing legal benchmarks evaluate only single-turn QA with outcome-level metrics, while agentic hallucination benchmarks lack legal-specific diagnostic capability. Neither answers to what extent and how a legal agent hallucinates along its trajectory. To address these limitations, we introduce LexAgentHallu, a legal agentic hallucination benchmark designed to evaluate to what extent and how legal agents fail along multi-step trajectories. Built through a four-stage expert-in-the-loop pipeline, LexAgentHallu contains 3414 instances across 17 legal categories and 6 task types. Each instance is annotated under a dual-layer hallucination taxonomy of 7 high-level categories and 27 fine-grained subclasses, covering both substantive errors and agent-procedural failures. We further design fine-grained metrics that quantify to what extent and localize how each failure occurs along an agent's execution path. Our evaluation across 18 proprietary and open-source agents uncovers a Right-Answer-Wrong-Reason effect and reveals that hallucination subclasses cluster rather than scatter, forming distinct agentic framework, legal task, and category profiles. These findings, invisible to outcome-level evaluation, validate the diagnostic power of LexAgentHallu for evaluating agentic hallucination in law.

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9

Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.

arXiv:2605.24834v1 Announce Type: cross Abstract: Large language model (LLM) safety classifiers such as Llama Guard are effective at detecting overtly harmful prompts but remain vulnerable to adversarial jailbreak attacks that disguise malicious intent through role-play scenarios, fictional framing, and indirect requests. We present Reflect-Guard, a method that augments LLM-based safety classifiers with chain-of-thought self-reflection capabilities through parameter-efficient fine-tuning. Our approach distills analytical reasoning from GPT-4o-mini into structured reflection annotations, then trains Llama-Guard-3-8B via QLoRA to generate logical self-reflections before issuing safety verdicts. Using only 1000 training examples and updating just 0.5% of model parameters (~42M), Reflect-Guard achieves substantial improvements on two challenging benchmarks. On WildGuardTest, F1 score improves from 0.770 to 0.842 (+7.2 pp), with recall on adversarial prompts increasing from 0.513 to 0.921 (+40.8 pp). On JailbreakBench, the attack success rate drops from 10.3% to 1.8%, representing an 82.5% relative reduction. These gains are especially pronounced on adversarial inputs, where the explicit reasoning step enables the model to see through obfuscation techniques that defeat standard pattern-matching approaches. Our results demonstrate that teaching safety classifiers to reason about adversarial intent, rather than simply classify surface patterns, is a promising direction for robust LLM safety.

Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.